Are Phosphatidylcholine and Lysophosphatidylcholine Body Levels Potentially Reliable Biomarkers in Obesity? A Review of Human Studies

Bellot, Paula Emília Nunes Ribeiro; Moia, M.; Reis, Bruna Zavarize; Pedrosa, Lúcia Fátima Campos; Tasić, Ljubica; Barbosa, Fernando Henrique de Souza; Sena-Evangelista, Karine Cavalcanti Maurício

doi:10.1002/mnfr.202200568

Cited by 22 publications

(13 citation statements)

References 57 publications

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“…Regarding phospholipids, that are the major components of biological membranes [ 53 ], we found reduced levels of lyso-phosphatidylcholines in obesity. In this context, some previous metabolomics reports also found decreased levels of lyso-phosphatidylcholines in obesity [ 54 , 55 ], specifically the species LPC (18:0) and LPC (18:2) in women [ 44 ], and the specie LPC (18:2) again in cohorts with men and women [ 56 – 58 ].…”

Section: Discussionmentioning

confidence: 82%

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Untargeted lipidomics analysis in women with morbid obesity and type 2 diabetes mellitus: A comprehensive study

Bertran,

Capellades,

Abelló

et al. 2024

PLoS ONE

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There is a phenotype of obese individuals termed metabolically healthy obese that present a reduced cardiometabolic risk. This phenotype offers a valuable model for investigating the mechanisms connecting obesity and metabolic alterations such as Type 2 Diabetes Mellitus (T2DM). Previously, in an untargeted metabolomics analysis in a cohort of morbidly obese women, we observed a different lipid metabolite pattern between metabolically healthy morbid obese individuals and those with associated T2DM. To validate these findings, we have performed a complementary study of lipidomics. In this study, we assessed a liquid chromatography coupled to a mass spectrometer untargeted lipidomic analysis on serum samples from 209 women, 73 normal-weight women (control group) and 136 morbid obese women. From those, 65 metabolically healthy morbid obese and 71 with associated T2DM. In this work, we find elevated levels of ceramides, sphingomyelins, diacyl and triacylglycerols, fatty acids, and phosphoethanolamines in morbid obese vs normal weight. Conversely, decreased levels of acylcarnitines, bile acids, lyso-phosphatidylcholines, phosphatidylcholines (PC), phosphatidylinositols, and phosphoethanolamine PE (O-38:4) were noted. Furthermore, comparing morbid obese women with T2DM vs metabolically healthy MO, a distinct lipid profile emerged, featuring increased levels of metabolites: deoxycholic acid, diacylglycerol DG (36:2), triacylglycerols, phosphatidylcholines, phosphoethanolamines, phosphatidylinositols, and lyso-phosphatidylinositol LPI (16:0). To conclude, analysing both comparatives, we observed decreased levels of deoxycholic acid, PC (34:3), and PE (O-38:4) in morbid obese women vs normal-weight. Conversely, we found elevated levels of these lipids in morbid obese women with T2DM vs metabolically healthy MO. These profiles of metabolites could be explored for the research as potential markers of metabolic risk of T2DM in morbid obese women.

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Section: Discussionmentioning

confidence: 82%

“…However, the metabolomic results used to be controversial in terms of these phospholipids. In any case, the most common trend is a negative association between BMI and most of phosphatidylcholines and lyso-phosphatidylcholines [ 53 ]. Again, Beyene et al .…”

Section: Discussionmentioning

confidence: 99%

Untargeted lipidomics analysis in women with morbid obesity and type 2 diabetes mellitus: A comprehensive study

Bertran,

Capellades,

Abelló

et al. 2024

PLoS ONE

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“…The present study indicated that PC was also correlated with BMI. Some studies confirmed that altered lipid metabolism (PCs and lysoPCs) were associated with lean body mass [ 44 , 45 ]. These studies were consistent with our experimental results.…”

Section: Discussionmentioning

confidence: 98%

Novel lipidomes profile and clinical phenotype identified in pneumoconiosis patients

Shi

Dai

Yan

et al. 2023

J Health Popul Nutr

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Background Pneumoconiosis is a group of occupational lung diseases caused by the inhalation of mineral dust in the lungs, leading to lung dysfunction. Patients with pneumoconiosis are usually accompanied by weight loss, which suggests a lipid metabolism disorder. Recent progress in lipidomics uncovered detailed lipid profiles that play important roles in respiratory diseases, such as asthma, lung cancer and lung injury. The purpose of this study was to shed light on the different expression of lipidome between pneumoconiosis and healthy, hoping to bring new ideas for the diagnosis and treatment of pneumoconiosis. Methodology This non-matching case–control study was performed among 96 subjects (48 outpatients with male pneumoconiosis and 48 healthy volunteers), data of clinical phenotypes were recorded, and plasma biochemistry (lipidomic profiles) was tested for both pneumoconiosis patients and healthy controls. A total of 426 species in 11 lipid classes were analyzed by high-performance liquid chromatography coupled with triple quadrupole tandem mass spectrometry (HPLC-QqQ-MS) for the cases and controls. We also analyzed the correlation of lipid profiles with clinical phenomes from pneumoconiosis patients by expression quantitative trait locus (eQTL) model to evaluate trans-nodules between lipidomic profiles and clinical phenomes. All visually re-checked data were analyzed using appropriate statistical tools (t-test or one-way ANOVA test) on SPSS. Results Compared with healthy people, 26 significantly increased (> 1.5-fold) and 30 decreased lipid elements (< 2/threefold) in patients with pneumoconiosis were identified (P values all < 0.05). The majority of those elevated lipid elements were phosphatidylethanolamines (PEs), and the minority were free fatty acids (FFAs), while phosphatidylcholines (PCs) and lysophosphatidylcholines (lysoPCs) declined in pneumoconiosis. Clinical trans-omics analyses demonstrated that phenomes in pneumoconiosis connections with multiple lipids, which showed that pH, lung function, mediastinal lymph node calcification, and complication were highly correlated with lipid elements. Furthermore, up-regulated PE was corresponded to pH, smoking history and mediastinal lymph node calcification. PC was corresponded to dust exposure history, BMI and mediastinal lymph node calcification. Conclusion We found altered lipid panels between male pneumoconiosis patients and healthy people by qualitatively and quantitatively measured plasma lipidomic profiles. The trans-omic analysis between clinical phenomes and lipidomes might have the potential to uncover the heterogeneity of lipid metabolism of pneumoconiosis patients and to screen out clinically significant phenome-based lipid panels.

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“…In adult obese humans and overweight/obese dogs, targeted metabolomic technologies revealed that PC aa C32:1, PC aa C32:2 and PC aa C38:3 were positively associated with overweight or obesity in both humans and dogs, though additional PC were also reportedly elevated in overweight and obese dogs compared to normal weight dogs [18,[53][54][55]. In humans, PC ae C34:3, PC ae C38:4, and PC ae C40:6 were negatively associated with obesity [53,56,57]; however no PC ae were lower in overweight or obese dogs [18].…”

Section: Plos Onementioning

confidence: 99%

Description of the fasted serum metabolomic signature of lean and obese cats at maintenance and of obese cats under energy restriction

Grant,

Godfrey,

Tal

et al. 2024

PLoS ONE

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This study aimed to investigate the serum metabolomic profile of obese and lean cats as well as obese cats before and after energy restriction for weight loss. Thirty cats, 16 obese (body condition score 8 to 9/9) and 14 lean (body condition score 4 to 5/9), were fed a veterinary weight loss food during a 4-week period of weight maintenance (L-MAINT and O-MAINT). The 16 obese cats were then energy restricted by a 60% energy intake reduction with the same food for a 10-week period (O-RESTRICT). Fasted serum metabolites were measured using nuclear magnetic resonance and direct infusion mass spectrometry after the maintenance period for L-MAINT and O-MAINT cats and after the energy restriction period for O-RESTRICT and compared between groups using a two-sided t-test. Obese cats lost 672 g ± 303 g over the 10-week restriction period, representing a weight loss rate of 0.94 ± 0.28% per week. Glycine, l-alanine, l-histidine, l-glutamine, 2-hydroxybutyrate, isobutryric acid, citric acid, creatine, and methanol were greater in O-RESTRICT compared to O-MAINT. There was a greater concentration of long-chain acylcarnitines in O-RESTRICT compared to both O-MAINT and L-MAINT, and greater total amino acids compared to O-MAINT. Glycerol and 3-hydroxybutyric acid were greater in O-MAINT compared to L-MAINT, as were several lysophosphatidylcholines. Thus, energy restriction resulted in increased dispensable amino acids in feline serum which could indicate alterations in amino acid partitioning. An increase in lipolysis was not evident, though greater circulating acylcarnitines were observed, suggesting that fatty acid oxidation rates may have been greater under calorie restriction. More research is needed to elucidate energy metabolism and substrate utilization, specifically fatty acid oxidation and methyl status, during energy restriction in strict carnivorous cats to optimize weight loss.

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Are Phosphatidylcholine and Lysophosphatidylcholine Body Levels Potentially Reliable Biomarkers in Obesity? A Review of Human Studies

Cited by 22 publications

References 57 publications

Untargeted lipidomics analysis in women with morbid obesity and type 2 diabetes mellitus: A comprehensive study

Untargeted lipidomics analysis in women with morbid obesity and type 2 diabetes mellitus: A comprehensive study

Novel lipidomes profile and clinical phenotype identified in pneumoconiosis patients

Description of the fasted serum metabolomic signature of lean and obese cats at maintenance and of obese cats under energy restriction

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