Are peroxiredoxins tumor suppressors?

Neumann, Carola A.; Fang, Quan

doi:10.1016/j.coph.2007.04.007

Cited by 115 publications

(93 citation statements)

References 49 publications

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“…Apart from the fact that Prxs act as tumor suppressors, Prxs have attracted attention in cancer research also due to the fact that their levels are drastically elevated in many cancer tissues and immortalized cell lines (Neumann and Fang 2007), which can lead to increased resistance to both radiotherapy and chemotherapy (e.g., cisplatin resistance) (Chung et al 2001). Specifically, increased PRX expression has been reported in several studies of both lung cancer and breast cancer (Noh et al 2001;Park et al 2006).…”

Section: Links Between Chemotherapy Resistance and Prx Activitymentioning

confidence: 99%

“…Before being recognized as gerontogenes, Prxs have received special attention in cancer research due to their association with signaling cascades, growth control, tumor suppression, and chemotherapy resistance (Neumann et al 2003;Chen et al 2006;Neumann and Fang 2007). To wit, deletion of yeast TSA1 causes a drastic loss of genome stability, gross chromosomal rearrangements (GCRs), and increased occurrence of base substitutions and frameshift mutations (Iraqui et al 2008(Iraqui et al , 2009).…”

Section: Links Between Genome Instability Cancer and Prx Activitymentioning

confidence: 99%

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Peroxiredoxins, gerontogenes linking aging to genome instability and cancer

2012

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Age is the highest risk factor known for a large number of maladies, including cancers. However, it is unclear how aging mechanistically predisposes the organism to such diseases and which gene products are the primary targets of the aging process. Recent studies suggest that peroxiredoxins, antioxidant enzymes preventing tumor development, are targets of age-related deterioration and that bolstering their activity (e.g., by caloric restriction) extends cellular life span. This review focuses on how the peroxiredoxin functions (i.e., as peroxidases, signal transducers, and molecular chaperones) fit with contemporary theories of aging and whether peroxiredoxins could be targeted therapeutically in the treatment of age-associated cancers.

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Section: Links Between Chemotherapy Resistance and Prx Activitymentioning

confidence: 99%

Section: Links Between Genome Instability Cancer and Prx Activitymentioning

confidence: 99%

Peroxiredoxins, gerontogenes linking aging to genome instability and cancer

2012

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“…It was not surprising to find 4 out of 6 human peroxiredoxins up-regulated in male tumors (PRDX1-4). Peroxiredoxins are antioxidant enzymes which reduce hydrogen peroxide and can indirectly affect cell proliferation: their role in cancer has been in fact extensively studied [19]. Similarly, the metabolism of glutathione, a potent reducing agent, seems to be affected.…”

Section: Energy Metabolismmentioning

confidence: 99%

Gene expression analysis reveals a different transcriptomic landscape in female and male breast cancer

Callari

Cappelletti

Cecco

et al. 2010

Breast Cancer Res Treat

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Results -Almost 1000 genes were found differentially expressed (FDR<1%) between female and male patients and biological interpretation highlighted a gender associated modulation of key biological processes ranging from energy metabolism to regulation of translation and matrix remodeling as well as immune system recruitment. Moreover, an analysis of genes correlated to steroid receptors and ERBB2 suggested a prominent role for the androgen receptor in MBC with a minor relevance for progesterone receptor and ERBB2, although, similarly to FBC, a genomic amplification could be observed.Conclusions -Our findings support the idea that breast cancer is a quite different disease in male and female patients and the underlying gender related biological differences are likely to have clinical implications connected with different susceptibility to treatment.3

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“…On the other hand, development of tumors might be reduced by peroxiredoxins, as they detoxify ROS and thereby help maintain genomic integrity. Therefore, peroxiredoxins have been suggested to be tumor preventers rather than tumor suppressors (20). Clearly, there is a strong need to test this hypothesis experimentally and to determine the roles of individual peroxiredoxins at different stages during the development and progression of various cancers.…”

mentioning

confidence: 99%

Dual Role of the Antioxidant Enzyme Peroxiredoxin 6 in Skin Carcinogenesis

et al. 2013

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The antioxidant enzyme peroxiredoxin 6 (Prdx6) is a key regulator of the cellular redox balance, particularly under stress conditions. We identified Prdx6 as an important player in different phases of skin carcinogenesis. Loss of Prdx6 in mice enhanced the susceptibility to skin tumorigenesis, whereas overexpression of Prdx6 in keratinocytes of transgenic mice had the opposite effect. The tumor-preventive effect of Prdx6, which was observed in a human papilloma virus 8-induced and a chemically induced tumor model, was not due to alterations in keratinocyte proliferation, apoptosis, or in the inflammatory response. Rather, endogenous and overexpressed Prdx6 reduced oxidative stress as reflected by the lower levels of oxidized phospholipids in the protumorigenic skin of Prdx6 transgenic mice and the higher levels in Prdx6-knockout mice than in control animals. In contrast to its beneficial effect in tumor prevention, overexpression of Prdx6 led to an acceleration of malignant progression of existing tumors, revealing a dual function of this enzyme in the pathogenesis of skin cancer. Finally, we found strong expression of PRDX6 in keratinocytes of normal human skin and in the tumor cells of squamous cell carcinomas, indicating a role of Prdx6 in human skin carcinogenesis. Taken together, our data point to the potential usefulness of Prdx6 activators or inhibitors for controlling different stages of skin carcinogenesis. Cancer Res; 73(11); 3460-9. Ó2013 AACR.

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Are peroxiredoxins tumor suppressors?

Cited by 115 publications

References 49 publications

Peroxiredoxins, gerontogenes linking aging to genome instability and cancer

Peroxiredoxins, gerontogenes linking aging to genome instability and cancer

Gene expression analysis reveals a different transcriptomic landscape in female and male breast cancer

Dual Role of the Antioxidant Enzyme Peroxiredoxin 6 in Skin Carcinogenesis

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