Are Periodontal Bacterial Profiles and Placental Inflammatory Infiltrate in Pregnancy Related to Birth Outcomes?

Abstract

COX-2 protein expression is higher in patients with GV and CP than in individuals without periodontal disease and is inversely correlated with the amount of connective tissue in the lamina propria as determined by image analysis. This finding suggests that COX-2 participates in mechanisms and pathway signaling related to the destruction of fibrillar support structures of the periodontium.

Chronic periodontitis is associated with erectile dysfunction. A case–control study in european population

“…The significance of the association between CP and other pathologies can be modified by the definition of periodontitis used (Manau, Echeverria, Agueda, Guerrero, & Echeverria, 2008). In this study, we adopted a strict definition of periodontitis, as proposed by Lopez et al, that has been previously used by our group (Mesa et al, 2013) and other authors (Gomes-Filho et al, 2007). This definition requires the presence of four or more teeth showing one or more sites with PPD ≥4 mm, CA loss ≥3 mm and BoP at the same site (Lopez et al, 2002).…”

Oral bacteria in placental tissues: increased molecular detection in pregnant periodontitis patients

“…In fact, the clinical association between periodontal disease and adverse pregnancy outcomes has been widely reported (Offenbacher et al , ; Madianos et al , ; López et al , ,b). Recent studies describe more severe and more frequent periodontal disease in mothers who have had preterm births (PB) or low birthweight infants (LBW) in comparison with full‐term mothers (Mesa et al , ). Konopka and Paradowska‐Stolarz observed in their meta‐analysis that mothers with periodontitis were 2.74 times more likely to have premature deliveries than mothers without periodontitis (Konopka and Paradowska‐Stolarz, ).…”

Factors Affecting Utilization of Dental Services During Pregnancy

“…Associations between periodontal disease and adverse pregnancy outcomes have been well documented, including preterm delivery, low birth weight, and preeclampsia 1‐9 . Transmission of oral microorganisms and/or their components to the fetal–placental unit via hematogenous dissemination or the genitourinary tract is one of the proposed pathways 10‐12 . In addition, local production of inflammatory mediators in periodontal tissues can reach and affect the fetal–placental unit directly or can enhance production of cytokines and acute‐phase proteins, which in turn affect the fetal–placental unit 10‐12 …”