Are People With Blood Group O More Susceptible to Nasopharyngeal Carcinoma and Have Worse Survival Rates? A Systematic Review and Meta-Analysis

Jing, Shaowu; Xu, Qing; Jing, Zhonghao; Zhao, Zhenzhen; Zhang, Ruo-hui; Wu, Fengpeng; Wang, Jun

doi:10.3389/fonc.2021.698113

Cited by 8 publications

(7 citation statements)

References 39 publications

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“…At present, it is considered that its pathogenesis is closely related to EB virus infection, chemical carcinogens, and genetic susceptibility genes [ 2 , 3 ]. Radiotherapy is still the main treatment for NPC, but the local recurrence and distant metastasis easily occur after radiotherapy, which limits its ability to further improve the survival rate of patients [ 4 ]. The research on the related pathogenesis and metastasis mechanism of NPC is beneficial to the discovery of specific diagnostic indicators and gene therapy targets for NPC and has far-reaching significance.…”

Section: Introductionmentioning

confidence: 99%

Relationship between miR-338-3p and Clinicopathological Parameters, Prognosis, and STAT3 mRNA Expression in Nasopharyngeal Carcinoma

Wang

Ren

Pan

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Objective. To investigate the expression of miR-338-3p in nasopharyngeal carcinoma (NPC) and its relationship with STAT3 mRNA expression as well as their relationship with clinical pathological parameters and prognosis of patients. Methods. From September 2016 to September 2018, 71 patients with NPC were selected as the NPC group, and 71 samples of NPC tissues were collected during the operation. A total of 23 patients who underwent biopsy due to chronic nasopharyngitis were selected as the control group and 23 nasopharyngeal mucosal tissues were collected. The expressions of miR-338-3p and STAT3 mRNA in nasopharyngeal tissue of two groups were detected by real-time quantitative PCR, and the relationship between the two was analyzed. To collect clinical data of NPC patients and analyze the relationship between the expressions of miR-338-3p and STAT3 in NPC tissues and clinical pathological parameters of the patients, we followed up the patients with nasopharyngeal carcinoma for three years to observe the relationship between miR-338-3p, STAT3, and the prognosis of the patients. Results. The relative expression levels of miR-338-3p in nasopharyngeal tissues of the NPC group and the control group were 0.39 ± 0.05 and 1.01 ± 0.09, respectively ( P < 0.05). The relative expression levels of STAT3 mRNA in nasopharyngeal tissues of the NPC group and the control group were 3.82 ± 0.21 and 1.04 ± 0.11, respectively ( P > 0.05). miR-338-3p was negatively correlated with the relative expression of STAT3 mRNA in nasopharyngeal carcinoma (r = 0.038, P > 0.05). The expression of miR-338-3p was related to the age of the patient, clinical TNM stage, T stage, and distant metastasis (all P < 0.05). STAT3 expression was correlated with clinical TNM stage, T stage, and distant metastasis in our patient ( P < 0.05). The expressions of miR-338-3p and STAT3 in nasopharyngeal carcinoma tissues from different gender, histological type, N stage, M stage, and degree of differentiation showed no statistical differences ( P > 0.05). The survival rate of the group with low miR-338-3p expression was significantly lower than that of the group with high miR-338-3p expression ( P > 0.05). The survival rate of patients with the high STAT3 expression group was significantly lower than that of patients with the low STAT3 expression group ( P > 0.05). Conclusion. There is a negative correlation between the low expression of miR-338-3p and the high expression of STAT3 in NPC, which are all related to the TNM stage, T stage, and prognosis of the patient.

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Section: Introductionmentioning

confidence: 99%

Relationship between miR-338-3p and Clinicopathological Parameters, Prognosis, and STAT3 mRNA Expression in Nasopharyngeal Carcinoma

Wang

Ren

Pan

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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“…Through extensive search, we collected quantitative evidence on ABO blood group associated with cancers and conducted meta‐analyses for 20 cancers totaling 20 million participants including 231 737 patients with eligible data across multiple comparison models. With an enlarged number of participants, our study provided updated summary effect estimates consistent with existing meta‐analyses on individual cancers, including significant associations with gastric cancer, 8 pancreatic cancer 7 and null associations for breast cancer, 16 liver cancer 17 and nasopharyngeal cancer 18 for some blood groups. Compared to prior studies this full‐scale investigation, featuring the extension of comparison models, cancer categorization and subgroup analysis by ethnicity, outlines an overall landscape of relationship between ABO blood group and cancers.…”

Section: Discussionmentioning

confidence: 61%

Epidemiological and genetic evidence for the relationship between ABO blood group and human cancer

Cui

Yang

Zhang

et al. 2023

Intl Journal of Cancer

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To comprehensively evaluate the etiological role of ABO blood group in human cancer, we conducted a large‐scale meta‐analysis of 127 publications totaling 20 million participants including 231 737 patients of 20 cancers, supplemented by genetic evidence. Effects of A, AB and B groups on cancer risk were investigated by respectively comparing with O group and their combined counterparts, and subgroup analysis by ethnicity was conducted for O‐referent models. For cancer categories, A group increased risk of cancers of oral cavity and nasopharynx, digestive and female genital organs, while both AB and B groups showed associations with cancers of digestive and female genital organs. For individual cancers, A group significantly increased the risk of nine cancers including oral cavity (OR = 1.17, P = .013), stomach (OR = 1.19, P = 3.90 × 10−15), pancreas (OR = 1.33, P = 9.89 × 10−33), colorectum (OR = 1.09, P = .001), liver (OR = 1.23, P = .011), ovary (OR = 1.13, P = .001), cervix (OR = 1.17, P = .025), bladder (OR = 1.12, P = .025) and breast (OR = 1.06, P = .043). AB group showed associations with only three cancers: stomach (OR = 1.10, P = .007), pancreas (OR = 1.21, P = .001) and ovary (OR = 1.28, P = .006). B group, except for shared associations with A group on pancreas (OR = 1.20, P = 2.27 × 10−5) and cervix cancers (OR = 1.13, P = .011), had two distinct associations with esophagus (OR = 1.17, P = .002) and nonmelanoma skin cancers (OR = 0.96, P = .017). Ethnicity‐specific analyses revealed the notable effects of non‐O groups on pancreatic cancer both in Caucasians and Asians. In genetic analysis, four SNPs were associated with the risk of pancreatic cancer, with rs505922 corresponding to O group showing the strongest protective effect (P = 1.16 × 10−23). Our study provided comprehensive evidence of ABO blood group associated with cancers and highlighted its carcinogenic role.

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“…The authors found that regarding the overall survival (OS) for locally advanced NPC patients with high lymphocyte levels, compared to non-A subgroups, the A blood group patients had better rates. A meta-analysis by Shao-wu Jing showed that, in Chinese patients, blood group O was associated with a lower incidence of NPC, while group A had no correlation with NPC [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Blood Group Type Association with Head and Neck Cancer

et al. 2022

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Background: We conducted an analysis to check whether the ABO blood group impacts the susceptibility or protection against different types of head and neck cancers. Method: We analyzed the medical records of 61,899 cancer patients from “Prof. Dr. Alexandru Trestioreanu” Institute of Oncology from Bucharest, along with the corresponding blood group type. Data were scraped using Python. For analysis, we used Chi-square test. Results: The blood group count was A (245, 45.12%) followed by 0 (160, 24.66%), B (110, 20.26%), and AB (28, 5.16%). Hypopharyngeal cancer was associated with B group, oral cavity cancer was associated with a lower risk in patients with B group while AB patients had a higher risk for oral cavity cancer (χ2 = 36.136, df = 18, p = 0.007). Conclusion: Blood group B is associated with an increased incidence for hypopharyngeal cancer, whereas, for the oral cavity, was associated lower incidence. Blood antigen A is associated with a higher risk of oral cavity cancer development, independent of B blood antigen.

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Are People With Blood Group O More Susceptible to Nasopharyngeal Carcinoma and Have Worse Survival Rates? A Systematic Review and Meta-Analysis

Cited by 8 publications

References 39 publications

Relationship between miR-338-3p and Clinicopathological Parameters, Prognosis, and STAT3 mRNA Expression in Nasopharyngeal Carcinoma

Relationship between miR-338-3p and Clinicopathological Parameters, Prognosis, and STAT3 mRNA Expression in Nasopharyngeal Carcinoma

Epidemiological and genetic evidence for the relationship between ABO blood group and human cancer

Blood Group Type Association with Head and Neck Cancer

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