Are Patients with Polycystic Ovarian Syndrome Ideal Candidates for Oocyte Donation?

Abstract

Background. The use of donated oocytes for in vitro fertilization treatment in patients with ovarian failure is universally recognized. But would patients with polycystic ovarian syndrome (PCOS) be a good choice for egg donation programs? Objective. Comparing the pregnancy rates of egg receptors from donor patients diagnosed with PCOS to receptors from donors without PCOS. Design. Retrospective cohort study. Methods. A total of 234 patients who had undergone egg reception program were separated into two groups: Group I, receptors from PCOS donors (n = 36); Group II, receptors from donors without PCOS (n = 198). Medical records were reviewed and the fertilization, implantation, and pregnancy rates were calculated. Results. PCOS patients had an average of 3.23 more oocytes retrieved, but there were no differences in the number of mature oocytes that were used for donation between the groups. We also observed that the number of transferred embryos was also not significantly different, as well as the fertilization and implantation rates. The clinical pregnancy rates were not significantly different: 28% and 26% in Group I and Group II, respectively. Conclusions. Women with PCOS should not be excluded from egg donation programs.

Endometrial Receptivity in Patients with Polycystic Ovary Syndrome

“…Since oocytes and embryo quality do not seems to be the cause of low implantation and pregnancy rate in PCOS patients as demonstrated by donor oocyte models [19,20], the decreased receptivity of the endometrium seems more probable. Indeed, accumulating data support the hypothesis that endometrium of PCOS patients is affected probably as a consequence of hormonal imbalance.…”

The Identification And Functional Analysis Of Circrnas In Endometrial Receptivity Of Mice With Polycystic Ovary Syndrome

“…Ovulation disorders/anovulation is an important cause of PCOS-related infertility,affecting 40% of women of reproductive age all over the world [2]. With the development of technology,PCOS patients can obtain highquality fertilized eggs with assisted reproductive technology(ART).However,studies found that the success rate of transplantation are lower and the spontaneous abortion are higher among the women with PCOS comparing to non-PCOS patients [3][4].Unexpectedly,using the oocytes donated by PCOS women will not lower fertilization,implantation and clinical pregnancy rates [5].Several pathophysiological changes in PCOS,like oligomenorrhea,hyperandrogen -ism, hyperinsulinemia, abnormal luteinizing hormone (LH) secretion and in ammation has been con rmed to compromise endometrial health in the long term,including dysfunctional endometrial receptivity(ER) [6][7].Endometrial receptivity refers to the status of the uterus when the endometrium is in synchrony with development of the blastocyst and is available to accept the blastocyst for adhesion, invasion and implantation [8].The decrease of endometrial receptivity is one of the most important causes of infertility or pregnancy loss.…”

Comment on “Are Patients with Polycystic Ovarian Syndrome Ideal Candidates for Oocyte Donation?”

“…The article “Are Patients with Polycystic Ovarian Syndrome Ideal Candidates for Oocyte Donation?” by Vaz et al [ 1 ] is important because IVF (in vitro fertilization) offers hope to millions of infertile couples. The demand and use of donated oocytes have increased significantly over the last decade.…”