Are Older Adults Who Volunteer to Participate in an Exercise Study Fitter and Healthier Than Nonvolunteers? The Participation Bias of the Study Population

Barreto, Philipe de Souto; Ferrandez, Anne-Marie; Saliba-Serre, Bérengère

doi:10.1123/jpah.10.3.359

Cited by 43 publications

(22 citation statements)

References 38 publications

(39 reference statements)

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“…This imminent, global “geriatric boom burden” is particularly pronounced among subpopulations of the VOCODFLEX, reaching the highest rate of disproportionate burden in end‐stage cancer patients (ESC patients) . Furthermore, although the numbers of specialists’ field‐specific clinical guidelines increase, older people are commonly excluded from most randomised controlled trials on which these guidelines are based. Application of all guidelines without regard to the trial populations from which they were created can lead to inappropriate prescribing and polypharmacy.…”

Section: Discussionmentioning

confidence: 99%

Inappropriate medication use and polypharmacy in end-stage cancer patients: Isn't it the family doctor's role to de-prescribe much earlier?

et al. 2018

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Though not representative of the whole end-stage cancer patient population, our study demonstrates that these patients are exposed to extensive polypharmacy. Most of these medications could have probably been safely de-prescribed much earlier in the course of the malignant disease. Considering the prolonged trust-based relationship with their patients, the family physicians are those who should be encouraged to implement the palliative approach and reduce polypharmacy much before reaching hospice settings.

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Section: Discussionmentioning

confidence: 99%

Inappropriate medication use and polypharmacy in end-stage cancer patients: Isn't it the family doctor's role to de-prescribe much earlier?

et al. 2018

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“…Individuals who volunteer for research studies are often more highly educated, have higher socio-economic status and are more sociable. Volunteer bias has been reported in an exercise intervention trial where participants were found to be fitter and healthier than non-volunteers [ 11 ]. Other studies have also suggested that volunteer bias might affect clinical trial results [ 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

Characteristics associated with willingness to participate in a randomized controlled behavioral clinical trial using home-based personal computers and a webcam

Dodge

Katsumata

Zhu

et al. 2014

Trials

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BackgroundTrials aimed at preventing cognitive decline through cognitive stimulation among those with normal cognition or mild cognitive impairment are of significant importance in delaying the onset of dementia and reducing dementia prevalence. One challenge in these prevention trials is sample recruitment bias. Those willing to volunteer for these trials could be socially active, in relatively good health, and have high educational levels and cognitive function. These participants’ characteristics could reduce the generalizability of study results and, more importantly, mask trial effects. We developed a randomized controlled trial to examine whether conversation-based cognitive stimulation delivered through personal computers, a webcam and the internet would have a positive effect on cognitive function among older adults with normal cognition or mild cognitive impairment. To examine the selectivity of samples, we conducted a mass mail-in survey distribution among community-dwelling older adults, assessing factors associated with a willingness to participate in the trial.MethodsTwo thousand mail-in surveys were distributed to retirement communities in order to collect data on demographics, the nature and frequency of social activities, personal computer use and additional health-related variables, and interest in the prevention study. We also asked for their contact information if they were interested in being contacted as potential participants in the trial.ResultsOf 1,102 surveys returned (55.1% response rate), 983 surveys had complete data for all the variables of interest. Among them, 309 showed interest in the study and provided their contact information (operationally defined as the committed with interest group), 74 provided contact information without interest in the study (committed without interest group), 66 showed interest, but provided no contact information (interest only group), and 534 showed no interest and provided no contact information (no interest group). Compared with the no interest group, the committed with interest group were more likely to be personal computer users (odds ratio (OR) = 2.78), physically active (OR = 1.03) and had higher levels of loneliness (OR = 1.16).ConclusionIncreasing potential participants’ familiarity with a personal computer and the internet before trial recruitment could increase participation rates and improve the generalizability of future studies of this type.Trial registrationThe trial was registered on 29 March 2012 at ClinicalTirals.gov (ID number NCT01571427).

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“…Another factor that could be contributing to these findings, although speculative, may reflect an issue with selfselection, such that patients who were physically active may have been more likely to participate in this study because it was advertised as being focused on lifestyle behaviors. There is evidence of participation bias in physical activity intervention studies, such that healthier, fitter participants are more likely to participate [56]. Although this study is cross-sectional and based on self-report, the way it was advertised may have contributed to participation bias, which may explain the high number of participants engaging in sufficient levels of physical activity.…”

Section: Discussionmentioning

confidence: 99%

The association between physical activity, sleep, and quality of life in patients in bio-chemical remission from Cushing’s syndrome

Moyers

Tiemensma

2020

Qual Life Res

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Purpose Cushing's syndrome can negatively affect patient's quality of life (QoL) after treatment and remission. Exposure to increased cortisol over time can result in visceral obesity, which makes this population vulnerable to cardiovascular risk factors associated with visceral obesity. Sleep disturbances are present in patients in remission from Cushing's syndrome, impacting QoL. Moderate intensity physical activity performed 3 times a week decreases visceral obesity and improves sleep quality, therefore, engaging in physical activity after remission may improve patient's QoL. The current study aims to explore the association between sleep quality, physical activity, and QoL in patients in remission of Cushing's syndrome. Methods Patients in biochemical remission from Cushing's syndrome (N = 147) were recruited through the Cushing's Support and Research Foundation. Quality of life was assessed using the Cushing Quality of Life Questionnaire (CushingQoL), sleep was assessed with the Pittsburgh Sleep Quality Index (PSQI), and physical activity levels were assessed with the Godin-Sheppard Leisure-Time Physical Activity Questionnaire (GSLTPAQ). Results Sleep quality was significantly associated with both subscales of the CushingQoL (both p < .001), but physical activity was not significantly associated with either subscale. Sleep was not significantly associated with physical activity engagement in this sample. Conclusion Results suggest that patients in remission from Cushing's syndrome experience sleep disturbances that are significantly associated with impaired QoL. Future research should focus on ameliorating the persisting clinical features of Cushing's syndrome that are associated with impaired QoL after biochemical remission to improve QoL and expedite complete functional remission.

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Are Older Adults Who Volunteer to Participate in an Exercise Study Fitter and Healthier Than Nonvolunteers? The Participation Bias of the Study Population

Cited by 43 publications

References 38 publications

Inappropriate medication use and polypharmacy in end-stage cancer patients: Isn't it the family doctor's role to de-prescribe much earlier?

Inappropriate medication use and polypharmacy in end-stage cancer patients: Isn't it the family doctor's role to de-prescribe much earlier?

Characteristics associated with willingness to participate in a randomized controlled behavioral clinical trial using home-based personal computers and a webcam

The association between physical activity, sleep, and quality of life in patients in bio-chemical remission from Cushing’s syndrome

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