Are neural crest stem cells the missing link between hematopoietic and neurogenic niches?

Coste, CÃ©cile; Neirinckx, Virginie; Gothot, A.; Wislet, Sabine; Rogister, Bernard

doi:10.3389/fncel.2015.00218

Cited by 11 publications

(11 citation statements)

References 109 publications

(119 reference statements)

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“…It is worth noting that this conversion can also be induced by epigenetic changes, and by intervention with hypomethylating agents [ 169 , 175 ]. The intriguing role of NCSCs and nervous-system components in the development and regulation of hematopoietic niche homeostasis seems to have been underestimated, as has recently been reviewed by Coste et al [ 176 ], and will be discussed in the context of MDS and AML below.…”

Section: Mspcs: Cell Of Originmentioning

confidence: 99%

Mesenchymal Stem and Progenitor Cells in Normal and Dysplastic Hematopoiesis—Masters of Survival and Clonality?

Pleyer

Valent

Greil

2016

IJMS

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Myelodysplastic syndromes (MDS) are malignant hematopoietic stem cell disorders that have the capacity to progress to acute myeloid leukemia (AML). Accumulating evidence suggests that the altered bone marrow (BM) microenvironment in general, and in particular the components of the stem cell niche, including mesenchymal stem cells (MSCs) and their progeny, play a pivotal role in the evolution and propagation of MDS. We here present an overview of the role of MSCs in the pathogenesis of MDS, with emphasis on cellular interactions in the BM microenvironment and related stem cell niche concepts. MSCs have potent immunomodulatory capacities and communicate with diverse immune cells, but also interact with various other cellular components of the microenvironment as well as with normal and leukemic stem and progenitor cells. Moreover, compared to normal MSCs, MSCs in MDS and AML often exhibit altered gene expression profiles, an aberrant phenotype, and abnormal functional properties. These alterations supposedly contribute to the “reprogramming” of the stem cell niche into a disease-permissive microenvironment where an altered immune system, abnormal stem cell niche interactions, and an impaired growth control lead to disease progression. The current article also reviews molecular targets that play a role in such cellular interactions and possibilities to interfere with abnormal stem cell niche interactions by using specific targeted drugs.

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Section: Mspcs: Cell Of Originmentioning

confidence: 99%

Mesenchymal Stem and Progenitor Cells in Normal and Dysplastic Hematopoiesis—Masters of Survival and Clonality?

Pleyer

Valent

Greil

2016

IJMS

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“…Additionally, the nervous system is an important regulator of HSC niche and its in luence is established early in development when stem cells are speci ied [212]. Neural crest-derived MSCs have regulatory pathways that control hematopoiesis in the hematopoietic niche [213]. Dyregulation between neural and hematopoietic systems can contribute to disease, thus repurposing of neuro-regulatory drugs may create new therapeutic opportunities to support hematopoiesis [212].…”

Section: Bone Marrow Microenvironment and Hematopoiesismentioning

confidence: 99%

The beneficial effects of varicella zoster virus

Al-Anazi¹,

Wk²,

Al-Jasser³

2019

J Hematol Clin Res

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Varicella zoster virus behaves differently from other herpes viruses as it differs from them in many aspects. Recently, there has been growing evidence on the benefi cial effects of the virus in immune compromised hosts and these effects are translated into prolongation of survival. The reported benefi cial effects of the virus include: (1) stimulation of bone marrow activity in patients with hematologic malignancies and bone marrow failure syndromes, (2) antitumor effects in various hematologic malignancies and solid tumors, and (3) association with graft versus host disease which has anticancer effects. Additionally, there are several reports on the safety of the live-attenuated even in severely immune suppressed individuals and on the emerging role of the virus in cancer immunotherapy. In this review, the following aspects of the virus will be thoroughly discussed: (1) new data on the genetic background, pathogenesis, vaccination, and new therapeutic modalities; (2) bone marrow microenvironment and hematopoiesis; (3) cells involved in the pathogenesis of the virus such as: mesenchymal stem cells, dendritic cells, natural killer cells, T-cells and mononuclear cells; (4) cellular proteins such as open reading frames, glycoproteins, promyelocytic leukemia protein, chaperons, and SUMOs; (5) extracellular vesicles, exosomes, and micro-RNAs; and (6) signaling pathways, cytokines, and interferons.

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“…However, detailed mechanisms underlying ROS signaling pathways in NSCs are not completely understood. Neurogenic niche contains NSC and HSC [ 140 ]. These two types of adult stem cells show similar reaction to ROS, suggesting that NSC metabolism is similar to HSC.…”

Section: Cell-based Therapeutic Strategies Against Oxidative Stresmentioning

confidence: 99%

Therapeutic Strategies for Oxidative Stress‐Related Cardiovascular Diseases: Removal of Excess Reactive Oxygen Species in Adult Stem Cells

Kim

Yun

Kwon

2016

Oxidative Medicine and Cellular Longevity

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Accumulating evidence indicates that acute and chronic uncontrolled overproduction of oxidative stress-related factors including reactive oxygen species (ROS) causes cardiovascular diseases (CVDs), atherosclerosis, and diabetes. Moreover ROS mediate various signaling pathways underlying vascular inflammation in ischemic tissues. With respect to stem cell-based therapy, several studies clearly indicate that modulating antioxidant production at cellular levels enhances stem/progenitor cell functionalities, including proliferation, long-term survival in ischemic tissues, and complete differentiation of transplanted cells into mature vascular cells. Recently emerging therapeutic strategies involving adult stem cells, including endothelial progenitor cells (EPCs), for treating ischemic CVDs have highlighted the need to control intracellular ROS production, because it critically affects the replicative senescence of ex vivo expanded therapeutic cells. Better understanding of the complexity of cellular ROS in stem cell biology might improve cell survival in ischemic tissues and enhance the regenerative potentials of transplanted stem/progenitor cells. In this review, we will discuss the nature and sources of ROS, drug-based therapeutic strategies for scavenging ROS, and EPC based therapeutic strategies for treating oxidative stress-related CVDs. Furthermore, we will discuss whether primed EPCs pretreated with natural ROS-scavenging compounds are crucial and promising therapeutic strategies for vascular repair.

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Are neural crest stem cells the missing link between hematopoietic and neurogenic niches?

Cited by 11 publications

References 109 publications

Mesenchymal Stem and Progenitor Cells in Normal and Dysplastic Hematopoiesis—Masters of Survival and Clonality?

Mesenchymal Stem and Progenitor Cells in Normal and Dysplastic Hematopoiesis—Masters of Survival and Clonality?

The beneficial effects of varicella zoster virus

Therapeutic Strategies for Oxidative Stress‐Related Cardiovascular Diseases: Removal of Excess Reactive Oxygen Species in Adult Stem Cells

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