Are nanotheranostics and nanodiagnostics-guided drug delivery stepping stones towards precision medicine?

Blau, Rachel; Krivitsky, Adva; Epshtein, Yana; Satchi‐Fainaro, Ronit

doi:10.1016/j.drup.2016.06.003

Cited by 40 publications

(22 citation statements)

References 169 publications

(105 reference statements)

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“…The development of precision drug delivery systems with precisely controlled stability and programmed drug release property has enormous potential to reduce the toxicity of the drugs and enhance their therapeutic efficacy. It will greatly facilitate the application of precision medicine in oncology for better care of cancer patients 2 .…”

Section: Introductionmentioning

confidence: 99%

“…Due to their superior biocompatibility, relatively smaller diameter (10–100 nm) and high capacity to encapsulate hydrophobic drugs, micellar nanoparticles are ideal candidates for the development of precision drug delivery systems 2–21 . Furthermore, recent advancement in materials sciences and nanotechnology has led to the creation of a new generation of such nanoparticles called stimuli-responsive cross-linked micellar nanoparticles (SCMNs).…”

Section: Introductionmentioning

confidence: 99%

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A facile strategy for fine-tuning the stability and drug release of stimuli-responsive cross-linked micellar nanoparticles towards precision drug delivery

et al. 2017

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Precision drug delivery has great impact on the application of precision oncology for better patient care. Here we report a facile strategy for fine-tuning the stability, drug release and responsiveness of stimuli-responsive cross-linked nanoparticles towards precision drug delivery. A series of micellar nanoparticles with different levels of intramicellar disulfide crosslinkages could be conveniently produced with a mixed micelle approach. These micellar nanoparticles were all within a size range of 25–40 nm so that they could take full advantage of the enhanced permeability and retention (EPR) effect for tumor-targeted drug delivery. The properties of these nanoparticles such as critical micelle concentration (CMC), stability, drug release and responsiveness to reductive environment could be well correlated to the levels of crosslink (LOC). Compared to the micellar nanoparticles with a LOC at 0% that caused death of animals of two species (mouse and rat) due to the acute toxicity such as hemolysis, the nanoparticles at all other levels of crosslink were much safer to be administered into animals. The in vitro antitumor efficacy of micellar nanoparticles crosslinked at lower levels (20% & 50%) were much more effective than that of 100% crosslinked micellar nanoparticles in SKOV-3 ovarian cancer cells.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A facile strategy for fine-tuning the stability and drug release of stimuli-responsive cross-linked micellar nanoparticles towards precision drug delivery

et al. 2017

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“…Their ultimate goal is to image and characterize the molecular profile of a disease, to follow in vivo drug delivery and drug efficacy in the hope of adapting the most tailored therapy and dose to each individual patient. Theranostics are often associated with nanomedicine as it is relatively straightforward to load nanoparticles simultaneously with therapeutic drugs and imaging probes to provide imaging and therapeutic capabilities within a single agent . In contrast, small‐molecule theranostic agents hold promise for easier characterization and better control of the physical‐chemical properties.…”

Section: Introductionmentioning

confidence: 99%

“…Theranostics are often associated with nanomedicine as it is relatively straightforward to load nanoparticles simultaneously with therapeutic drugs and imaging probes to providei maging and therapeutic capabilities within as ingle agent. [7] In contrast, small-moleculet heranostic agents hold promise for easier characterization and better control of the physical-chemical properties. Gd 3 + complexes combinedw ith therapeutic approaches have been widely investigated in this context,b oth in the class of nanoparticles and molecular probes.…”

Section: Introductionmentioning

confidence: 99%

Lanthanide Complexes in Molecular Magnetic Resonance Imaging and Theranostics

Lacerda

Tóth

2017

ChemMedChem

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Lanthanide complexes have attracted much attention in the biomedical field, and today various imaging applications make use of their versatile magnetic and luminescence properties. In this minireview, we give insight into the mechanistic aspects that allow modulation of the relaxation or chemical exchange saturation transfer (CEST) features, and thus the magnetic resonance imaging (MRI) efficiency of paramagnetic lanthanide chelates in order to create agents that are capable of providing an MRI response as a function of a specific biomarker. We focus on the detection of neurotransmitters, enzymatic activities, and amyloid peptides. We also describe two selected theranostic strategies: 1) a novel approach directed at monitoring drug release from liponanoparticles and 2) molecular or nanoparticle probes for the MRI visualization of photosensitizer delivery in photodynamic therapy.

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“…Multifunctional nanoparticles that label tumours for additional imaging have been increasingly introduced in the field of oncology research [10]. These nanoparticles are usually coupled with targeting ligands such as antibodies for cancer biomarker targeting [11].…”

Section: Introductionmentioning

confidence: 99%

Focused ultrasound induced hyperthermia accelerates and increases the uptake of anti-HER-2 antibodies in a xenograft model

Centelles

Wright

Gedroyc

et al. 2016

Pharmacological Research

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Image guided drug delivery has gained significant attention during the last few years. Labelling nanoparticles or macromolecules and monitoring their fate in the body provides information that can be used to modulate their biodistribution and improve their pharmacokinetics. In this study we label antibodies and monitor their distribution in the tumours post intravenous injection. Using Focused Ultrasound (FUS, a non-invasive method of hyperthermia) we increase the tumour temperature to 42°C for a short period of time (3-5min) and we observe an increased accumulation of labelled antibody. Repetition of focused ultrasound induced hyperthermic treatment increased still further the accumulation of the antibodies in the tumour. This treatment also augmented the accumulation of other macromolecules non-specific to the tumour, such as IgG and albumin. These effects may be used to enhance the therapeutic efficiency of antibodies and/or targeted nanoparticles.

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Are nanotheranostics and nanodiagnostics-guided drug delivery stepping stones towards precision medicine?

Cited by 40 publications

References 169 publications

A facile strategy for fine-tuning the stability and drug release of stimuli-responsive cross-linked micellar nanoparticles towards precision drug delivery

A facile strategy for fine-tuning the stability and drug release of stimuli-responsive cross-linked micellar nanoparticles towards precision drug delivery

Lanthanide Complexes in Molecular Magnetic Resonance Imaging and Theranostics

Focused ultrasound induced hyperthermia accelerates and increases the uptake of anti-HER-2 antibodies in a xenograft model

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