Are Muslim women less susceptible to oncogenic human papillomavirus infection? A study from rural eastern India

Duttagupta, Chandralekha; Sengupta, Shamik; Roy, Meera; Sengupta, Debapriya; Bhattacharya, Paramita; Laikangbam, P.; Roy, Sudipta; Ghosh, Supriti; Das, R

doi:10.1111/j.1048-891x.2004.014213.x

Cited by 26 publications

(33 citation statements)

References 33 publications

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“…High-risk HPV types 16 and 18 were detected in 8.2% of the entire sample and in 22% of the samples positive for HPV DNA types 6, 11, 16, 18, 31 and 33, using consensus primers. The prevalence of HPV 16/18 in the index study, is consistent with that reported by Duttagupta et al [20] Probable incrementing factor for the high prevalence of HPV DNA is poor hygiene. It is corroborated by the observation that a significant number, i.e., 58% of positive women had vaginitis.…”

Section: Discussionsupporting

confidence: 91%

Prevalence of high - risk human papillomavirus infections in women with benign cervical cytology: A hospital based study from North India

et al. 2006

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INTRODUCTION:Cervical cancer is the commonest cancer among Indian women. High-risk human papillomavirus (HPV) detection holds the potential to be used as a tool to identify women, at risk for subsequent development of cervical cancer. There is a pressing need for identifying prevalence of asymptomatic cervical HPV infection in the local population. OBJECTIVE: To determine the prevalence of high-risk HPV DNA in women with benign cervical cytology. MATERIALS AND METHODS: Women visiting the gynecology outpatient with varied complaints were subjected to Pap smear. Four hundred and seventy two samples were subjected to polymerase chain reaction, using consensus primers for low and high-risk HPV (types 6, 11, 16, 18, 31 and 33). The samples that were positive for HPV DNA were subsequently assessed for high-risk consensus primers, types 16, 18, 31 and 33 as well as for HPV type 16 and 18. RESULTS: One hundred and seventy four (36.8%) women tested positive for HPV DNA. Thirty nine (8.2%) of the entire cohort tested positive for high-risk HPV. Fifteen samples were positive for type 16, 22 for type 18 and two for both types 16 and 18. A statistically higher prevalence of high-risk HPV was observed in poorly educated and rural groups. No association of HPV prevalence was noted with age, parity and age at marriage. CONCLUSION:The study generates epidemiological data of prevalence of sub-clinical HPV in the women visiting a tertiary care institute as well as peripheral health centres. The data generated will be useful for laying guidelines for mass screening of HPV, treatment and prophylaxis in the local population.

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Section: Discussionsupporting

confidence: 91%

Prevalence of high - risk human papillomavirus infections in women with benign cervical cytology: A hospital based study from North India

et al. 2006

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“…Most previous surveys in developing countries (Duttagupta et al, 2004), including those by IARC, had to rely on locally read cytology and indeed showed a much lower agreement between cytological findings and HPV results than in our present study, where 85% of moderate and severe dyskaryosis (corresponding to high-grade squamous intraepithelial lesions, HSIL) harboured high-risk HPV types. Moderate or severe dyskaryoses were never found below 25 years in Dindigul District, but their prevalence increased with age and in women aged 45 or older it was approximately four-fold greater than in women in the same age group in England (Department of Health, 2000).…”

Section: Papillomavirus In Rural India S Franceschi Et Alcontrasting

confidence: 90%

“…The combined prevalence in a rural area of West Bengal of HPV types 16 and 18 in 534 Hindu women and 478 Muslim women was 7.5 and 9.6%, respectively (Duttagupta et al, 2004). HPV 16 and 18 positivity was similar in four age groups (o25, 25 -34, 35 -44, X45 years) among Muslim women, but steeply declined with age among Hindu women.…”

Section: Discussionmentioning

confidence: 91%

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Papillomavirus infection in rural women in southern India

Rajkumar²,

et al. 2005

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To investigate the prevalence of, and the risk factors for, cervical infection with 44 types of human papillomavirus (HPV) in a rural area in the Dindigul District, Tamil Nadu, India, we interviewed and obtained cervical cell samples from 1891 married women aged 16 -59 years. HPV prevalence was 16.9% overall and 14.0% among women without cervical abnormalities, or 17.7 and 15.2%, respectively, age-standardised to the world standard population. In all, 21.9% of infections involved more than one HPV type. High-risk HPV types predominated, particularly HPV 16 (22.5% of women infected), followed by HPV 56, HPV 31, HPV 33 and HPV 18. Unlike most populations studied in developed countries, HPV prevalence was constant across the age groups. HPV positivity was inversely associated with education level (odds ratio (OR) among women with high school vs no education ¼ 0.6) and positively associated with widowhood and divorce (OR ¼ 1.7), nulligravidity (OR ¼ 2.3), and condom use (OR ¼ 2.6). It is unclear how much low clearance of, or frequent reinfection with HPV accounted for the study prevalence of infection in different age groups.

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“…In contrast, in Bali a significant decline in HPV prevalence with increasing age was seen, as in some western countries, in Korea and among Hindu women in India (Duttagupta et al, 2004). In the latter, the reproductive period (and thus active sexual life) of Hindu women mostly ends by the age of 30 -35 years, which could explain the decreasing prevalence observed.…”

Section: Discussionmentioning

confidence: 80%

Prevalence of human papillomavirus in Indonesia: a population-based study in three regions

et al. 2008

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Cervical cancer is the most common cancer among women in the Indonesian population, yet little is known about the prevalence of human papillomavirus (HPV). We investigated age-specific prevalence of HPV types and possible risk factors of HPV positivity in a population-based sample of 2686 women, aged 15 -70 years, in Jakarta, Tasikmalaya, and Bali, Indonesia. The overall HPV prevalence was 11.4%, age-standardized to the world standard population 11.6%. The most prevalent types found were HPV 52, HPV 16, HPV 18, and HPV 39, respectively, 23.2, 18.0, 16.1, and 11.8% of the high-risk HPV types. In 20.7% of infections, multiple types were involved. Different age-specific prevalence patterns were seen: overall high in Jakarta, and in Tasikmalaya, and declining with age in Bali. The number of marriages was most associated with HPV positivity (OR 1.81 95% CI 1.31 -2.51)). Remarkably, in Indonesia HPV 16 and HPV 18 are equally common in the general population, as they are in cervical cancer. HPV 52 was the most prevalent type in the general population, suggesting that this type should be included when prophylactic HPV vaccination is introduced in Indonesia. Cervical cancer is the most common cancer in women in Indonesia, as in most developing countries (Tjindarbumi and Mangunkusumo, 2002;Parkin et al, 2005). From hospital-based data, it accounts for 28.6% of female cancers in Indonesia (Tjindarbumi and Mangunkusumo, 2002).Human papillomavirus (HPV) prevalence, age-specific prevalence, and type of distribution differ substantially between populations (Clifford et al, 2005;Franceschi et al, 2006) and HPV 18 has a greater role in cervical cancer in Indonesia than in the rest of the world. HPV 18 was found as frequently as HPV 16 in cervical cancer (Schellekens et al, 2004), or even more frequently than HPV 16 (Bosch et al, 1995). A small hospital-based case -control study conducted in Jakarta also found a high prevalence of HPV 18 in controls (de Boer et al, 2006). In view of the lack of population-based relevant data, we report here the age-specific prevalence data for HPV among women in Jakarta and Tasikmalaya on the island of Java and among women on the island of Bali, and assess possible risk factors in the aetiology of cervical cancer. MATERIAL AND METHODSThis population-based study was conducted as part of a screening project for cervical cancer in Jakarta and Tasikmalaya on the island of Java and different regions on the island of Bali in Indonesia between October 2004 and February 2006. Women were excluded if they were virgin, pregnant, had undergone a hysterectomy, or had previous cervical cancer. During our study it appeared that only married, divorced or widowed women participated in screening. Women who had never been married would strictly still be virgins because sexual intercourse before marriage is not allowed following Indonesia's cultural and religious rules.To reach women, in each region a collaboration was set up with the Pembinaan Kesejahteraan Keluarga (PKK), the national Indonesian Family Welfare Or...

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Are Muslim women less susceptible to oncogenic human papillomavirus infection? A study from rural eastern India

Cited by 26 publications

References 33 publications

Prevalence of high - risk human papillomavirus infections in women with benign cervical cytology: A hospital based study from North India

Prevalence of high - risk human papillomavirus infections in women with benign cervical cytology: A hospital based study from North India

Papillomavirus infection in rural women in southern India

Prevalence of human papillomavirus in Indonesia: a population-based study in three regions

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