Are Mean Platelet Volume and Platelet Distribution Width Useful Parameters in Children With Acute Rheumatic Carditis?

Özdemir, Rahmi; Karadeniz, Cem; Doksöz, Önder; Çeleğen, Mehmet; Yozgat, Yılmaz; Güven, Barış; Meşe, Timur; Ünal, Nurettin

doi:10.1007/s00246-013-0738-9

Cited by 32 publications

(34 citation statements)

References 15 publications

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“…There was no correlation between BVAS/WG, GFR and MPV. MPV values have previously been studied in various inflammatory conditions, such as familial mediterranean fever, rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, juvenile SLE, psoriasis, systemic sclerosis and acute rheumatic fever [16,[25][26][27][28][29][30][31]. But the results are contradictory.…”

Section: Discussionmentioning

confidence: 99%

Platelet/lymphocyte ratio and mean platelet volume in patients with granulomatosis with polyangiitis

et al. 2019

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Background: Granulomatosis with polyangiitis (GPA) is a granulomatous necrotizing vasculitis with high morbidity and mortality. Anti-neutrophil cytoplasmic antibody is a valuable diagnostic marker, however its titer lacks predictive value for the severity of organ involvement. Platelet to lymphocyte ratio (PLR) and mean platelet volume (MPV) has been regarded as a potential marker in assessing systemic inflammation. We aimed to explore the value of PLR and MPV in the assessment of disease activity and manifestations of disease in GPA. Methods: 56 newly diagnosed GPA patients and 53 age-sex matched healthy controls were included in this retrospective and cross-sectional study with comparative group. Complete blood count was performed with Backman Coulter automatic analyzer, erythrocyte sedimentation rate (ESR) with Westergen method and C-reactive protein (CRP) levels with nephelometry. The PLR was calculated as the ratio of platelet and lymphocyte counts. Result: Compared to control group, ESR, CRP and PLR were significantly higher and MPV significantly lower in GPA patients. In patients group, PLR was positively correlated with ESR and CRP (r = 0.39, p = 0.005 and r = 0.51, p < 0.001, respectively). MPV was negatively correlated with ESR and CRP (r = − 0.31, p = 0.028 and r = − 0.34 p = 0.014, respectively). Patients with renal involvement had significantly higher PLR than patients without renal involvement (median:265.98, IQR:208.79 vs median:180.34 IQR:129.37, p = 0.02). PLR was negatively correlated with glomerular filtration rate (r = − 0.27, p = 0.009). A cutoff level of 204 for PLR had 65.6% sensitivity and 62.5 specificity to predict renal involvement. Conclusion: PLR exhibit favorable diagnostic performance in predicting renal involvement in patients with GPA.

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Section: Discussionmentioning

confidence: 99%

Platelet/lymphocyte ratio and mean platelet volume in patients with granulomatosis with polyangiitis

et al. 2019

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“…MPV is also a useful indicator in some inflammatory diseases, and it has been associated with disease activity and severity of inflammation [18]. Released inflammatory mediators in cancer increase platelet activation, leading to a subsequent change in MPV [19].…”

Section: Discussionmentioning

confidence: 99%

Absolute Neutrophil Count and Mean Platelet Volume in the Blood as Biomarkers to Detect Lung Cancer

2020

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Objective. Inflammation plays an extremely considerable role in the development and progression of malignancies. Absolute neutrophil count (ANC) and mean platelet volume (MPV) in blood are associated with various inflammatory conditions and resulted in independent prognostic factors for lung cancer. However, whether ANC and MPV can be diagnostic markers for lung cancer remains unknown. This retrospective study investigated the roles of ANC and MPV, either alone or combined, in diagnosing lung cancer. Methods. This study analyzed data from lung cancer patients and healthy individuals in Wuxi People’s Hospital Affiliated with Nanjing Medical University. The Mann–Whitney U-test was performed to compare differences between lung cancer patients and healthy individuals. Spearman’s correlation analysis was used to assess correlations. Receiver operating characteristic (ROC) curves were performed to determine diagnostic accuracy. Results. 209 patients diagnosed with lung cancer and 236 healthy subjects were enrolled in this study. Levels of ANC and MPV increased in lung cancer patients compared with healthy individuals (P<0.001). ANC had statistically significant negative weak correlation with albumin concentrations (r=‐0.154, P=0.026), and MPV had statistically significant negative weak correlation with total protein concentrations (r=‐0.153, P=0.027) in lung cancer patients. ANC and neutrophil-to-lymphocyte ratio had statistically significant positive correlation in both lung cancer patients (r=0.756, P<0.001) and healthy subjects (r=0.639, P<0.001). MPV and platelet-to-lymphocyte ratio had statistically significant negative weak correlation in both lung cancer patients (r=‐0.242, P<0.001) and healthy subjects (r=‐0.325, P<0.001). ANC had sensitivity (SEN) and specificity (SPE) of 0.512 and 0.809, respectively, and the area under the curve (AUC) with 95% confidence interval (95% CI) was 0.656 (0.603-0.710). SEN and SPE of MPV were 0.928 and 0.708, respectively, and the AUC (95% CI) was 0.913 (0.889-0.938). When ANC and MPV were combined, SEN and SPE became 0.842 and 0.835, respectively, and the AUC (95% CI) became 0.919 (0.895-0.943). Conclusions. Compared with ANC or MPV alone, the combination of ANC and MPV can improve diagnostic ability to distinguish lung cancer patients from healthy subjects.

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“…Rheumatic carditis is an autoimmune inflammatory disorder that develops due to the body's abnormal and exaggerated immune response against beta hemolytic streptococci. The disease occurs through a cytokine-mediated inflammatory reaction in which both cellular and humoral immune mechanisms play a role in susceptible individuals [1]. In their study, Guilherme et al examined the surgical specimens of heart valves and myocardium collected from 18 patients with severe RHD.…”

Section: Discussionmentioning

confidence: 99%

Red blood cell distribution width: can it be a predictive marker for long‐term valvular involvement in children with acute rheumatic carditis?

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Özdemir

Karadeniz

et al. 2016

Int J Lab Hematology

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Are Mean Platelet Volume and Platelet Distribution Width Useful Parameters in Children With Acute Rheumatic Carditis?

Cited by 32 publications

References 15 publications

Platelet/lymphocyte ratio and mean platelet volume in patients with granulomatosis with polyangiitis

Platelet/lymphocyte ratio and mean platelet volume in patients with granulomatosis with polyangiitis

Absolute Neutrophil Count and Mean Platelet Volume in the Blood as Biomarkers to Detect Lung Cancer

Red blood cell distribution width: can it be a predictive marker for long‐term valvular involvement in children with acute rheumatic carditis?

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