Are Markers of Allergic Inflammation in Grass Pollen Allergy Influenced by H1 Antihistamines?

Abstract

Soluble intercellular adhesion molecule-1 (ICAM-1) and soluble vascular adhesion molecule-1 (VCAM-1) play important roles in allergic rhinitis (AR). Treatment with H1 antihistamines improves AR symptoms and in vitro reduces the levels of adhesion molecules. The aim of the study was to evaluate serum levels of ICAM-1 and VCAM-1 in patients with AR to grass pollen and their response to different H1 antihistamines. Material and methods: A total of 50 patients with grass pollen AR were clinically and biologically evaluated. ICAM-1 and VCAM-1 serum levels were evaluated during pollen season before and after treatment with levocetirizine and desloratadine through the ELISA method. Results: ICAM-1, VCAM-1, eosinophils, and total IgE were elevated in patients with AR, compared with healthy subjects. Both antihistamines improved specific symptoms of AR and increased patients’ quality of life during pollen season after one month of treatment. H1 antihistamines reduced VCAM-1, ICAM-1, and total IgE after one-month treatment but not significantly. Patients with increased baseline values tend to remain with increased values after one-month AH1 treatment. Conclusions: ICAM-1 and sVCAM-1 levels are higher in patients with grass pollen-induced AR than healthy controls during pollen exposure. Their serum levels tend to remain at high values during pollen season despite antihistaminic therapy.

Development and in vitro/in vivo evaluation of a nanosponge formulation loaded with Boswellia carterii oil extracts for the enhanced anti-inflammatory activity for the management of respiratory allergies

“…It acts by enhancing the aggregation of neutrophils. When it is activated, it causes accumulation of inflammatory and immune effector cells in addition to its action on T cells in the immune response, leading to potentiation of the release of cytokines (Bocsan et al 2021). Results showed that the effect of treatment on inhibition of the Ilβ4 level were in the order of O1 > BO > D4.…”

“…Results obtained on treatment with DEX salt can be explained in light of the study of Bocsan et al, who revealed that ICAM-1 levels were greater in patients sensitized with pollen grains and suffering allergic rhinitis, than non-sensitized individuals during pollen exposure. On the other hand, treatment with antihistaminic therapy didn't lower their levels in sera during pollen season (Bocsan et al 2021). In a related investigation, Vestbo and associates prospectively tracked 290 individuals with mild to moderate chronic obstructive pulmonary disease (COPD) and discovered no variation in the pace of inflammatory mediator decrease.…”