Are latent variable models preferable to composite score approaches when assessing risk factors of change? Evaluation of type-I error and statistical power in longitudinal cognitive studies
Abstract:As with many health constructs, cognition is difficult to measure accurately; it is assessed by multiple psychometric tests. Two approaches are commonly adopted to address this multivariate aspect in longitudinal analyses: the composite score approach summarizes the tests into a single outcome and subsequently analyzes its change; the multivariate approach relates the tests to the underlying cognitive level and simultaneously analyzes its change. We compared the quality of inference of these approaches in a si… Show more
“…The ROSMAP investigators are committed to timely data sharing of raw or processed data which can be found on our Resource Sharing Hub with relevant links to the AMP-AD Knowledge Portal [297, 298]. A sample of work done with ROSMAP data including as part of translational studies and consortia is provided to give the community a better sense of the range of work that could be done leveraging the resource [299