Are Iranians Aware of Carbon Monoxide Poisoning: Symptoms and Its Prevention Strategies?

Emami-Razavi, Seyed Hassan; Ghajarzadeh, Mahsa; Aziz, Sepehr; Keyvan, Amirhossein; Mirjafari, Seyedeh Adeleh; Sodagari, Faezeh

doi:10.18502/acta.v57i8.2432

Cited by 3 publications

(4 citation statements)

References 12 publications

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“…In HL conditions, MPO may displace PON1, rendering HDL pro-oxidant and pro-atherogenic. [40] It has been previously reported that the decreased PON1 activity, cumulated with the increased MPO activity in plasma of acute coronary syndrome patients, is associated with low concentrations of circulating HDL-C. [41] In addition, plasma MPO/PON1 ratio was suggested as a potential predictor of dysfunctional HDL and an indicator of risk stratification in coronary artery disease patients. [10,42] We have previously reported that HL causes the decrease of apoA-I protein in the SI.…”

Section: Discussionmentioning

confidence: 99%

Hyperlipidemia Determines Dysfunctional HDL Production and Impedes Cholesterol Efflux in the Small Intestine: Alleviation by Ginger Extract

Barbalata

Deleanu

Carnuta

et al. 2019

Molecular Nutrition Food Res

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Scope To assess the impact of ginger extract (GIN) in stimulating the production of quality HDL and the cholesterol efflux in the small intestine (SI), key processes in the management of hyperlipidemia (HL)‐induced hepatic steatosis, and atherosclerosis. Methods and results Three groups of hamsters are used: (i) N, fed standard diet, (ii) HL, fed high‐fat diet for 21 weeks, and (iii) HL‐GIN, HL treated with GIN for the last 5 weeks of diet. Apolipoprotein A‐I (apoA‐I), malondialdehyde‐apoA‐I (MDA‐apoA‐I), paraoxonase1 (PON1), and myeloperoxidase (MPO) are measured in plasma and SI. ATP‐binding cassette A1 transporter (ABCA1), ABCG5/G8, liver X receptor α/β (LXRα/β), peroxisome proliferator‐activated receptor γ (PPARγ), and sirtuin1 (SIRT1) are assessed in the SI. Results show that in HL plasma, GIN decreases MDA‐apoA‐I, MPO/PON1 ratio and increases HDL‐cholesterol/total cholesterol. In HL‐SI, GIN decreases MDA‐apoA‐I and MPO, increases ApoA‐I, PON1, and ABCA1, and restores cholesterol efflux disturbed by HL (SIRT1‐LXRα/β‐PPARγ‐ABCG8). GIN administration is associated with the reduction of the aortic valves lipid‐deposits. Conclusion In HL conditions, GIN stimulates the functional HDL production by restoring apoA‐I quality and quantity through inhibition of the oxidative stress, and increases cholesterol efflux in the SI. These effects are associated with the restoration of SIRT1‐LXRα/β‐PPARγ pathway.

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Section: Discussionmentioning

confidence: 99%

Hyperlipidemia Determines Dysfunctional HDL Production and Impedes Cholesterol Efflux in the Small Intestine: Alleviation by Ginger Extract

Barbalata

Deleanu

Carnuta

et al. 2019

Molecular Nutrition Food Res

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“…Included studies ranging from 2000 to 2021; the result showed that CO poisoning is still a significant burden though it is possibly preventable. An Iranian study concluded that most are unaware of all CO poisoning symptoms (Emami- Razavi et al, 2014). A retrospective study conducted at Dammam, KSA, aimed to assess CO poisoning from 2004 to 2013.…”

Section: Medical Science L Analysis Articlementioning

confidence: 99%

“…Conversely, we discovered that most of our respondents were seen to have adequate practice levels in all of the prevention practices. The importance of CO detectors at home had also been discussed by (Emami et al, 2014). According to their reports, (89.1%) of Iranis reported that CO detectors would be helpful for the decrease of mortality rates from CO poisoning, whereas (84.4%) reported that opening window is important prevention of CO leakage and (93.8%) indicated that, their fuel burning devices were checked by an expert at the beginning of the winter.…”

Section: Prevention Practicesmentioning

confidence: 99%

Social knowledge of symptoms, risk factors, causes, and preventive measures of CO poisoning among Saudi Arabia's general population

AlMulhim¹,

AlJumaah²,

AlGharash³

et al. 2022

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Background: Carbon monoxide (CO) is a highly poisonous gas that has no identifiable colour or odor. People could be affected by CO emissions from various sources that include gas stoves, water heaters, fire places and motor vehicles. Aim: The study aims to assess the perception & knowledge regarding symptoms, risk factors, causes and preventive measures of CO poisoning among the Kingdom of Saudi Arabia (KSA) general population. Subjects and methods: This is a cross sectional study of the general population of the KSA.The study targeted non health care providers using an electronic survey. The questionnaire mainly consists of three parts; socio-demographic data, knowledge assessment, habitual factors and practices related to CO poisoning.Results: Out of 568 participants, (52.8%) were aged between 18 to 25 years with (64.1%) being females. The majority had poor knowledge (67.6%), negative attitude (72.4%) but good prevention practices (64.4%). Conclusion: There was a deficiency in terms of knowledge and attitude. However preventive practices are inspiring. Respondents who have heard about CO poisoning tend to exhibit better knowledge and practices as compared to the rest of the population.

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“…In Iran, CO is called “silent-killer” and causes a considerable number of poisonings especially during winter season because of insufficient ventilations when using gas appliances as a source of warming ( 1 3 4 ).…”

Section: Introductionmentioning

confidence: 99%

Magnesium sulfate protects the heart against carbon monoxide-induced cardiotoxicity in rats

et al. 2018

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Carbon monoxide (CO), a toxic gas produced via incomplete fossil fuel combustion, has several poisonous effects in the heart including induction of necrosis, apoptosis, and electrocardiogram (ECG) changes. Magnesium sulfate (MS) is a drug with cardioprotective effects especially when used after ischemia/reperfusion. In the current study, we aimed to evaluate MS cardioprotective effects following CO poisoning. Animals were exposed to CO 3000 ppm for 1 h and immediately after the exposure period and on the next 4 days (a total of 5 consecutive doses given on a daily basis), MS (75, 150 and 300 mg/kg) was injected intraperitoneally (i.p.) and ECG was recorded focusing on ST-segment, T-wave, and Q-pathologic wave changes. On day 5, animals were sacrificed and their heart was excised for determination of BAX, BCL2 and Akt expression level using western blot analysis and necrosis investigations. The results showed that MS significantly decreased necrosis and BAX/BCL2 ratio (P < 0.001) while pro-survival protein Akt was significantly increased (P < 0.001). Moreover, CO-induced ST-segment depression, T-wave inversion, and atrioventricular block (AV-block) were decreased following treatment with MS. In conclusion, our results showed that MS could decrease cardiac deleterious effects of CO poisoning including necrosis and apoptosis while increased the expression of Akt, as a cell survival protein.

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Are Iranians Aware of Carbon Monoxide Poisoning: Symptoms and Its Prevention Strategies?

Abstract: The article's abstract is no available.

Cited by 3 publications

References 12 publications

Hyperlipidemia Determines Dysfunctional HDL Production and Impedes Cholesterol Efflux in the Small Intestine: Alleviation by Ginger Extract

Hyperlipidemia Determines Dysfunctional HDL Production and Impedes Cholesterol Efflux in the Small Intestine: Alleviation by Ginger Extract

Social knowledge of symptoms, risk factors, causes, and preventive measures of CO poisoning among Saudi Arabia's general population

Magnesium sulfate protects the heart against carbon monoxide-induced cardiotoxicity in rats

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