Are Ionic Liquids Better Extracting Agents Than Toxic Volatile Organic Solvents? A Combination of Ionic Liquids, Microwave and LC/MS/MS, Applied to the Lichen Stereocaulon glareosum

Calla-Quispe, Erika; Robles, Juana; Areche, Carlos; Sepúlveda, Beatriz

doi:10.3389/fchem.2020.00450

Cited by 21 publications

(19 citation statements)

References 19 publications

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“…22 Moreover, the interest of these cations to extract various lichen metabolites was recently confirmed. 23 We have also reported an optimisation study 27 using six imidazolium and pyridinium-based ILs for MAE from Pseudevernia furfuracea. Microwave irradiation is generally more efficient to extract the targeted lichen metabolites (Figure 1) than conventional heating.…”

Section: Selectivity Of Ils In Maementioning

confidence: 99%

“…22 An additional study was recently performed on Stereaucolon glareosum confirming the ability of imidazolium cations to interact with lichen metabolites. 23 In this work, we explore various parameters influencing the IL-MAE of four metabolites from Pseudevernia furfuracea var. furfuracea (Figure 1) including the method used to prepare the samples and the structure of ILs.…”

Section: Introductionmentioning

confidence: 99%

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Efficiency and selectivity of ionic liquids in microwave‐assisted extraction of major lichen phenolic compounds: a scalable process with recycling of ionic liquids

Komaty

Sauvager

Bazureau

et al. 2020

Phytochemical Analysis

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Introduction: Pseudevernia furfuracea, a lichen used classically for cosmetic applications, contains interesting metabolites possessing antimicrobial and anti-inflammatory or antioxidant properties.Objectives: Ionic liquid combined to microwave-assisted extraction (IL-MAE) was successfully applied for metabolites extraction from Pseudevernia furfuracea.Materials and methods: Three imidazolium and pyridinium-based ionic liquids (ILs):EtSO 4 ], and N-ethylpyridinium ethylsulphate [C 2 Py][EtSO 4 ] were assessed for this process. The efficiency of the extraction method was evaluated using thin-layer chromatography (TLC) coupled to a Camag® spectrophotodensitometer and using high-performance liquid chromatography (HPLC) analysis. Results: ILs under MAE showed extraction time efficiency (15 min vs. 24 h for conventional heating) and high selectivity in extracting the targeted metabolites: atranorin (AT), methyl-β-orcinol carboxylate (MOC), fumarprotocetraric acid (Fum. Ac.), and physodic acid (Phys. Ac.) despite the increased degradation of AT under MAE. We showed a tunable selectivity of ILs towards extracting metabolites by changing anion or cation due to the modification of the interaction between the IL and the metabolites. While [C 2 Py][EtSO 4 ] was the most efficient IL and could extract all the targeted metabolites, [C 2 C 1 Im][EtSO 4 ] was the most selective. It fully extracted AT and partially Fum. Ac. Moreover, the lichen prepared by mixing procedure provided AT and Fum. Ac. more than the milled one. A 100 times scale-up extraction was successfully performed on mixed samples with full IL recycling after back extraction. Conclusion: IL-MAE is reliable for lichen metabolites extraction. The method is reproducible, scalable, with possible IL recycling, opening the door for potential industrial applications.

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Section: Selectivity Of Ils In Maementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficiency and selectivity of ionic liquids in microwave‐assisted extraction of major lichen phenolic compounds: a scalable process with recycling of ionic liquids

Komaty

Sauvager

Bazureau

et al. 2020

Phytochemical Analysis

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“…For example, for the extraction of non-polar components, such as lipids, polyketides and terpenoids, one may use water-immiscible solvents such as ethyl acetate or dichloromethane. Other water-immiscible solvents such as ethers, chloroform and carbon tetrachloride are less common due to their toxicity and negative environmental effects [134,179]. Additionally, pH is crucial for the extraction, due to ionizable moieties in the chemical structure of the metabolites being extracted into the organic phase to a much higher degree in their neutral form than in a charged state.…”

Section: Identification Of Non-volatile Compounds Of Fungal Originmentioning

confidence: 99%

“…Other chromatographic techniques use two consecutive separation columns (2-dimensional liquid chromatography) or columns of different sorbent chemistry, such as ionic exchangers (see Table 1) [14,113,129,134,143]. The most common ionization techniques used in combination with 2D liquid chromatography are the ambient pressure ionization techniques, such as electrospray ionization (ESI) [134,135,137,138,[140][141][142][143][144][145]150] and atmospheric pressure chemical ionization (APCI) [139,146]. These are all soft ionization techniques (i.e., they produce limited chemical fragmentation).…”

Section: Identification Of Non-volatile Compounds Of Fungal Originmentioning

confidence: 99%

Mass Spectrometry: A Rosetta Stone to Learn How Fungi Interact and Talk

Calla-Quispe

Fuentes-Rivera

Ramírez

et al. 2020

Life

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Fungi are a highly diverse group of heterotrophic organisms that play an important role in diverse ecological interactions, many of which are chemically mediated. Fungi have a very versatile metabolism, which allows them to synthesize a large number of still little-known chemical compounds, such as soluble compounds that are secreted into the medium and volatile compounds that are chemical mediators over short and long distances. Mass spectrometry (MS) is currently playing a dominant role in mycological studies, mainly due to its inherent sensitivity and rapid identification capabilities of different metabolites. Furthermore, MS has also been used as a reliable and accurate tool for fungi identification (i.e., biotyping). Here, we introduce the readers about fungal specialized metabolites, their role in ecological interactions and provide an overview on the MS-based techniques used in fungal studies. We particularly present the importance of sampling techniques, strategies to reduce false-positive identification and new MS-based analytical strategies that can be used in mycological studies, further expanding the use of MS in broader applications. Therefore, we foresee a bright future for mass spectrometry-based research in the field of mycology.

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“…New alternative solvents have gained increasing attention in research due to the negative impact of traditional chemicals on people and the environment. Therefore, they are employed as eco-friendly extractants and sorbents to replace the old ones (Sepulveda et al, 2020). Mainly, ionic liquids (ILs) and deep eutectic solvents (DESs) contribute greatly to separation science besides their use as an extraction medium (Marták and Schlosser, 2019); they can also assist adsorbents to improve separation performance by the disaggregation of nano-materials into smaller bundles (Zaib et al, 2020).…”

mentioning

confidence: 99%

Rethinking the Applications of Ionic Liquids and Deep Eutectic Solvents in Innovative Nano-Sorbents

2021

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With the development of green chemistry and nano materials, new alternatives to traditional volatile solvents are one of many important hotspots in the field of nano materials. Ionic liquids (ILs) and deep eutectic solvents (DESs) as excellent alternative solvents are being applied in the innovation of nano-sorbents, including nanoparticles, nanogels, and nanofluid. ILs and DESs are often used as carriers/modifiers/dispersers of nano-sorbents to enhance the adsorption capacity and selectivity in the extraction procedure. Various extraction technologies, such as solid-phase extraction, solid-phase microextraction, micro-solid phase extraction, hollow fiber liquid phase microextraction, and magnetic solid-phase extraction, have also been promoted by them to achieve rapid development. This paper focused on the latest development of nano-sorbents based on ILs and DESs. The problems and bottlenecks encountered were analyzed in order to provide meaningful and valuable references for the related research and thus promote further development and application of alternative solvents-assisted nano-sorbents.

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Are Ionic Liquids Better Extracting Agents Than Toxic Volatile Organic Solvents? A Combination of Ionic Liquids, Microwave and LC/MS/MS, Applied to the Lichen Stereocaulon glareosum

Cited by 21 publications

References 19 publications

Efficiency and selectivity of ionic liquids in microwave‐assisted extraction of major lichen phenolic compounds: a scalable process with recycling of ionic liquids

Efficiency and selectivity of ionic liquids in microwave‐assisted extraction of major lichen phenolic compounds: a scalable process with recycling of ionic liquids

Mass Spectrometry: A Rosetta Stone to Learn How Fungi Interact and Talk

Rethinking the Applications of Ionic Liquids and Deep Eutectic Solvents in Innovative Nano-Sorbents

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