In instructional communication settings, instructional explanations play an important role. Despite the very common use of instructional explanations, empirical studies show that very often, they have no positive effects on learning outcomes. This ineffectiveness might be due to mental passivity of the recipient learners that leads to shallow processing of the explanations. Against this background, we introduce several types of instructional assistance to foster active processing of written instructional explanations in asynchronous computer-mediated instructional communication settings. The findings of three experiments showed that prompts or training for focused processing regarding the central principles and concepts of the explanation are especially effective with respect to fostering learning outcomes. Keywords Asynchronous computer-mediated instructional communication . Written instructional explanations . Active processing . Focused processing In instructional communication settings, instructional explanations play an important role. The most prevalent activity in natural human tutoring is providing explanations (Chi et al. 2001). Instructional explanations are designed with the specific purpose of teaching (e.g., Leinhardt and Steele 2005) and communicating a particular aspect of the learning contents. Despite the very common use of instructional explanations, empirical studies show that very often, they have no positive effects on learning outcomes (e.g., Chi et al. 2001; VanLehn et al. 2003 for tutor settings; Webb 1989 for peer settings; for an overview, see Wittwer and Renkl 2008).This ineffectiveness might be partly attributed to problems on the part of the instructor in adapting his or her messages to the knowledge and needs of the learner or recipient. Wittwer, Nückles, and Renkl (this issue) proposed that instructional explanations should be tailored to an individual learner and developed an approach to provide instructors with information about a learner's understanding. In this way, the instructor is able to diagnose Educ Psychol Rev (2010) 22:25-40