Are Infertile Men Less Healthy Than Fertile Men? An Analysis of the National Survey for Family Growth

Persily, Jesse; Thakker, Sameer; Beaty, William; Najari, Bobby B.

doi:10.1016/j.urology.2021.05.054

Cited by 4 publications

(6 citation statements)

References 25 publications

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“…Only six case control studies of couples undergoing fertility treatment have been identified incorporating the role of male obesity on risk of infertility. 3,4,[17][18][19] Three of these studies utilised men with clearly documented infertility, 4,17,18 and found higher BMI in the infertile cohort in two of the three studies. 4,17 Another study utilised self-reported infertility (based on survey questions regarding prior infertility treatment) and did not identify a difference in BMI between the fertile and infertile groups.…”

Section: Pregnancy and Assisted Reproductionmentioning

confidence: 99%

“…4,17 Another study utilised self-reported infertility (based on survey questions regarding prior infertility treatment) and did not identify a difference in BMI between the fertile and infertile groups. 19 Two further studies used time to pregnancy cut-offs to determine subfertility. One study from China of 50,927 couples utilised a cut-off of 6 months to determine subfertility and identified no relationship to paternal BMI.…”

Section: Pregnancy and Assisted Reproductionmentioning

confidence: 99%

“…A few studies have assessed the role of paternal obesity on pregnancy outcomes in the previous 5 years (Table 1). Only six case control studies of couples undergoing fertility treatment have been identified incorporating the role of male obesity on risk of infertility 3,4,17–19 . Three of these studies utilised men with clearly documented infertility, 4,17,18 and found higher BMI in the infertile cohort in two of the three studies 4,17 .…”

Section: Update On the Effects Of Obesity On Male Fertilitymentioning

confidence: 99%

“…Three of these studies utilised men with clearly documented infertility, 4,17,18 and found higher BMI in the infertile cohort in two of the three studies 4,17 . Another study utilised self‐reported infertility (based on survey questions regarding prior infertility treatment) and did not identify a difference in BMI between the fertile and infertile groups 19 . Two further studies used time to pregnancy cut‐offs to determine subfertility.…”

Section: Update On the Effects Of Obesity On Male Fertilitymentioning

confidence: 99%

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Sperm DNA damage: The possible link between obesity and male infertility, an update of the current literature

et al. 2023

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Obesity prevalence worldwide is increasing significantly. Whilst maternal obesity has clear detrimental impacts on fertility, pregnancy and foetal outcomes, more recently there has been an increasing focus on the role of paternal obesity in human fertility. Recent meta‐analyses have indicated that obesity in men negatively affects basic sperm parameters such as sperm count, concentration and motility, increases the incidence of infertility and reduces the chances of conception. Sperm DNA damage, typically characterised by DNA strand breaks and oxidation of DNA nucleotides, is a specialised marker of sperm quality that has been independently associated with recurrent miscarriage, reduced assisted reproduction success and increased mutational loads in subsequent offspring. Whilst, there are still conflicting data in humans as to the association of obesity in men with sperm DNA damage, evidence from rodent models is clear, indicating that male obesity increases sperm DNA damage. Human data are often conflicting because of the large heterogeneity amongst studies, the use of body mass index as the indicator of obesity and the methods used for detection of sperm DNA damage. Furthermore, comorbidities of obesity (i.e., heat stress, adipokines, insulin resistance, changes in lipids, hypogonadism and obstructive sleep apnoea) are also independently associated with increased sperm DNA damage that is not always modified in men with obesity, and as such may provide a causative link to the discrepancies amongst human studies. In this review, we provide an update on the literature regarding the associations between obesity in men and fertility, basic sperm parameters and sperm DNA damage. We further discuss potential reasons for the discrepancies in the literature and outline possible direct and indirect mechanisms of increased sperm DNA damage resulting from obesity. Finally, we summarise intergenerational obesity through the paternal linage and how sperm DNA damage may contribute to the transmission.

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Section: Pregnancy and Assisted Reproductionmentioning

confidence: 99%

Section: Pregnancy and Assisted Reproductionmentioning

confidence: 99%

Section: Update On the Effects Of Obesity On Male Fertilitymentioning

confidence: 99%

Section: Update On the Effects Of Obesity On Male Fertilitymentioning

confidence: 99%

See 2 more Smart Citations

Sperm DNA damage: The possible link between obesity and male infertility, an update of the current literature

et al. 2023

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“…Infertility is a rising global health issue which has a deep impact on couples’ psychosocial life and male factors cover about 50% of all infertility causes (Persily et al., 2021). Azoospermia, defined as the absence of spermatozoa in the ejaculate, is seen ~1% of all male population and this rate is increased up to 10% in men seeking solutions for infertility complaints (Kavoussi et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

Systemic immune‐inflammation index, neutrophil‐lymphocyte ratio and platelet‐lymphocyte ratio are predictors of sperm presence in microdissection testicular sperm extraction

et al. 2022

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Infertility is a rising global health issue which has a deep impact on couples' psychosocial life and male factors cover about 50% of all infertility causes (Persily et al., 2021). Azoospermia, defined as the absence of spermatozoa in the ejaculate, is seen ~1% of all male population and this rate is increased up to 10% in men seeking solutions for infertility complaints (Kavoussi et al., 2020). Etiologically, azoospermia can be subdivided into two categories as obstructive and non-obstructive.

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Male Infertility: A Retrospective Review of Laboratory Charts at a Tertiary Teaching Hospital in Nairobi City County

2024

EASci

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Background: Globally, approximately 50 million couples experience one form of infertility, and 10 million cases of subfertility have been reported in sub-Saharan Africa. Infertility is characterized by a lack of clinical conception among couples who live together for more than one year with regular coitus, without the use of contraception. Factors related to fertility vary by sex and geographical region. These factors include age, lifestyle, infectious diseases, and genetic disorders. In African culture, children are considered a simple inheritance and a measure of masculinity, so efforts are needed to address the growing problem of male infertility in this context. Objective: To determine the prevalence of male infertility among adult men seeking semen analysis services in a tertiary teaching hospital in Nairobi, Kenya. Methods: This was a cross-sectional study that involved a retrospective review of archived electronic data in the hospital information system. These data were from male patients who visited the laboratory with a request for semen analysis between January 2016 and December 2020. A checklist was used to extract data related to sociodemographic factors and laboratory results (age, seminal volume, and diagnosis). Results: The average age of the male clients seen during the review period was 36±8 years, with the majority aged 31-40 years n= 996 (46.7%). The youngest was 21 years old, and the oldest was 70 years old. The total prevalence of seminal abnormalities was 1628 (77%) of the 2131 electronic data that was reviewed. Only 502 (23%) of the patients had a normal seminal diagnosis. Most clients exhibited at least one form of seminal abnormalities, such as asthenospermia 913 (43%), oligospermia 441 (21%), and azoospermia 272 (13%). There was a statistically significant association between age and seminal abnormality (X 2 = 31.393, P=.013). A significant association was also found between seminal volume and abnormalities (X 2 = 94.538, P=.000). Conclusion: Our findings showed that there were some seminal abnormalities among Kenyan men in Nairobi County. More effort is required to identify the cause of this increase in seminal abnormalities. Initiation of health interventions to reduce this burden of infertility may be necessary. Peer Reviewed Acknowledgments:The authors thank Aga Khan University School of Nursing and Midwifery for giving us time to collect the data for this study. The authors also thank our departmental colleagues for their encouragement and help in conceptualising this study.

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Are Infertile Men Less Healthy Than Fertile Men? An Analysis of the National Survey for Family Growth

Cited by 4 publications

References 25 publications

Sperm DNA damage: The possible link between obesity and male infertility, an update of the current literature

Sperm DNA damage: The possible link between obesity and male infertility, an update of the current literature

Systemic immune‐inflammation index, neutrophil‐lymphocyte ratio and platelet‐lymphocyte ratio are predictors of sperm presence in microdissection testicular sperm extraction

Male Infertility: A Retrospective Review of Laboratory Charts at a Tertiary Teaching Hospital in Nairobi City County

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