Are individuals with severe haemophilia A prone to reduced bone density?

Mansouritorghabeh, Hassan; Rezaieyazdi, Zahra; Badiei, Zahra

doi:10.1007/s00296-008-0591-y

Cited by 23 publications

(39 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hepatitis C has been cited as a potential risk factor but the results are conflicting, with some studies supporting the association [11,13,14,20] and others not [1,21,24,27]. This study demonstrated that patients with a history of HCV had lower BMD at the hip than non-affected patients, and that a history of HCV was an independent predictor for reduced BMD at the femoral neck.…”

Section: Discussionmentioning

confidence: 60%

A case–control study assessing bone mineral density in severe haemophilia A in the UK

et al. 2014

View full text Add to dashboard Cite

It has been shown that bone mineral density (BMD) may be lower in patients with haemophilia (PWH). A comparison to control subjects is required to thoroughly assess current BMD in PWH in the UK. The objective of this study was to test the hypothesis that BMD is lower in PWH than in controls, and in patients with more severely affected joints or lower activity levels. In this case-control study, 37 patients with severe haemophilia A were recruited from two haemophilia centres in the UK. A group of 37 age, gender and ethnicity-matched control participants were recruited. All participants had a bone density scan, a musculoskeletal assessment, a blood test for vitamin D and completed a functional activity questionnaire. Of the case group, 5% had osteoporosis and 24% had BMD lower than expected for age. No control participants had osteoporosis, 3% had osteopenia and 14% had BMD lower than expected for age. Ninety one per cent of case participants and 92% of control participants had reduced 25(OH)D levels. Case participants had significantly lower BMD than control participants, and case participants with more severely affected joints, lower activity levels, HIV, history of hepatitis C or lower BMI had significantly lower BMD. Patients with severe haemophilia have a higher risk of low BMD than men without haemophilia. Patients with more severely affected joints and lower activity levels have lower BMD. It remains unclear whether patients with low BMD reached adequate peak bone mass. Low vitamin D may be present in the majority of PWH.

show abstract

Section: Discussionmentioning

confidence: 60%

A case–control study assessing bone mineral density in severe haemophilia A in the UK

et al. 2014

View full text Add to dashboard Cite

show abstract

“…These findings were confirmed in a study by Mansouritorghabeh et al. [32]. Weight‐bearing physical activity (sports), physical therapy, surgery to remobilize patients, and calcium and vitamin D supplementation are recommended [33].…”

Section: Haemophilic Arthropathymentioning

confidence: 69%

Co‐morbidity in the ageing haemophilia patient: the down side of increased life expectancy

2009

View full text Add to dashboard Cite

Because of an increased life expectancy, (age-related) co-morbidity is becoming a common occurrence in haemophilia patients. In this review, haemophilia-related and non-haemophilia-related medical problems, treatment recommendations and psychosocial consequences in ageing haemophilia patients are discussed. Haemophilic arthropathy is an important cause of pain and disability, and a frequent indication for surgery in haemophilia patients. In addition, many adult patients are infected with hepatitis C or HIV, the consequences and treatment of which can add to physical and mental discomfort. Moreover, inhibitors against factor VIII can also develop in adulthood, especially in patients with mild haemophilia. Hypertension is reported to occur more often in haemophilia patients than in the general population. Other internal problems, like renal abnormalities, overweight, diabetes mellitus and hypercholesterolemia are discussed. Haemophilia seems to protect against cardiovascular disease, although the incidence is increasing. Recommendations are given on dealing with tooth extractions, surgical interventions and sexuality problems in patients with haemophilia. In addition to haemophilia in itself, co-morbidity has a major psychological impact, and an important effect on quality of life. It can also result in complex treatment regimens, in which coordination between health care workers is essential.

show abstract

“…The interleukin 1 (IL-1) and tumour necrosis factor-alpha (TNF-) which are mediator of inXammation may encourage RANK-L production via T-cells [7]. HCV can inXuence peak bone mass by causing abnormalities in metabolisms of vitamin D and testosterone, so several studies with higher patients number could show correlation between HCV and RBD, [7,12] while some other surveys could not establish this concept mostly due to low numbers of patients entered the studies [4,5,13].…”

Section: Pathogenesis Of Reduced Bone Densitymentioning

confidence: 97%

“…Bone mass status is the result of equilibrium between bone mass gaining during childhood period and bone loss during adulthood. So it is highly important to obtain suYcient bone mass during childhood [4]. It has been demonstrated that individuals with higher bone mass at the end of adolescence have higher protection against the gradual decrease in bone mass during ageing [5,6].…”

Section: Introductionmentioning

confidence: 99%

Bleeding disorders and reduced bone density

Mansouritorghabeh

Rezaieyazdi

2010

Rheumatol Int

Self Cite

View full text Add to dashboard Cite

In recent decays, quality of life and life expectancy of individuals with severe haemophilia A and B have been improved by better quality in treatment and more availability of blood coagulation products. Recently, new concerns have emerged in current groups such as auto-antibody inhibitors to coagulation factors and reduced bone density (RBD). RBD in bleeding disorders is becoming an escalating burden worldwide due to an increased in life expectancy and also in the ageing population with bleeding disorders. Here, we review published papers on bone mineral density of individuals with haemophilia A & B, a rare bleeding disorder entitled combined factor V and VIII deficiency and other rare bleeding disorders. It seems in individuals with bleeding disorders preventive measures including early detection, treatment and adequate physical activity, encouragement to be active in sports and finally anti-osteoporotic therapy must be done.

show abstract

Are individuals with severe haemophilia A prone to reduced bone density?

Cited by 23 publications

References 7 publications

A case–control study assessing bone mineral density in severe haemophilia A in the UK

A case–control study assessing bone mineral density in severe haemophilia A in the UK

Co‐morbidity in the ageing haemophilia patient: the down side of increased life expectancy

Bleeding disorders and reduced bone density

Contact Info

Product

Resources

About