Are high‐ and low‐molecular‐weight sensitizing agents associated with different clinical phenotypes of occupational asthma?

Vandenplas, Olivier; Godet, Julien; Hurdubaea, Laura; Rifflart, Catherine; Suojalehto, Hille; Wiszniewska, Marta; Muñoz, Xavier; Sastre, Joaquı́n; Klusáčková, Pavlína; Moore, Vicky; Merget, R.; Talini, D; Svanes, Cecilie; Mason, Paola; DellʼOmo, Marco; Cullinan, Paul; Moscato, Gianna; Quirce, Santiago; Hoyle, Jennifer; Sherson, David; Kauppi, Paula; Preisser, Alexandra M.; Meyer, Nicolás; Blay, F. De

doi:10.1111/all.13542

Cited by 82 publications

(94 citation statements)

References 38 publications

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“…The LMW-OA phenotype is currently associated with a higher prevalence of late asthmatic reaction on SIC, although the reaction was early in the present case. SIC did not significantly increase FeNO level, which is also described more frequently in this phenotype [9,10]. The postchallenge increase in the sputum eosinophil count was significant and similar to the value reported by previous studies [9], thus confirming the switch from the paucigranulocytic pattern to the eosinophilic inflammatory pattern induced by exposure to the causal agent.…”

supporting

confidence: 86%

“…SIC did not significantly increase FeNO level, which is also described more frequently in this phenotype [9,10]. The postchallenge increase in the sputum eosinophil count was significant and similar to the value reported by previous studies [9], thus confirming the switch from the paucigranulocytic pattern to the eosinophilic inflammatory pattern induced by exposure to the causal agent. These data suggest that the sputum eosinophil count could be a better predictive biomarker of OA than FeNO level.…”

supporting

confidence: 86%

“…The case we describe shares several typical characteristics of the LMW-OA phenotype with recent reports [9], namely, absence of atopy and other work-related diseases (eg, rhinitis, conjunctivitis, and urticaria), high AHR, paucigranulocytic inflammatory sputum profile, and normal FeNO level. The LMW-OA phenotype is currently associated with a higher prevalence of late asthmatic reaction on SIC, although the reaction was early in the present case.…”

supporting

confidence: 80%

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Occupational Asthma Caused by Powder Paint in the Automotive Industry

Tiotiu

Thaon

Mathias

et al. 2019

J Investig Allergol Clin Immunol

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supporting

confidence: 86%

supporting

confidence: 86%

supporting

confidence: 80%

See 1 more Smart Citation

Occupational Asthma Caused by Powder Paint in the Automotive Industry

Tiotiu

Thaon

Mathias

et al. 2019

J Investig Allergol Clin Immunol

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“…While irritantinduced asthma is attributed to a non-immunological mechanism, sensitizing agents induce asthma through mechanisms which may or may not be type-2dependent. In fact, a recent study showed that both high-molecular-weight agents (with an IgE-mediated mechanism) and low-molecular-weight agents (with as yet undefined mechanisms) may generate eosinophilic or neutrophilic responses [15].…”

Section: Discussionmentioning

confidence: 99%

Sudan red dye: a new agent causing type-2 occupational asthma

Clofent

Homdedeu

Muñoz-Esquerre

et al. 2020

Allergy Asthma Clin Immunol

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Background: Sudan red or 1-[(2-methoxyphenyl)azo]-2-naphthol is a low molecular weight azoic agent widely used in industry, particularly in the production of hair dyes. The use of this product in the food industry is prohibited due to its potential carcinogenic effect, but no respiratory involvement has been reported to date. Case presentation:We present the case of a 46-year-old female patient who had been working in a cosmetics packaging company for 20 years. The patient developed occupational asthma to a red azo dye known as Sudan red. The diagnosis was confirmed by specific bronchial provocation test. Induced sputum samples were obtained previously and in the 24 h following the procedure, with a rise in the percentage of eosinophils from 10 to 65%. Conclusions:This report describes the case of a patient who developed OA caused by exposure to an azoic dye called Sudan red. The clinical and analytical features suggest a type 2-related asthma; however, we are not yet able to confirm the specific pathophysiological mechanism. The extensive use of azo dyes in industry means that it is particularly important to describe their implications for health, which are probably underestimated at present.

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“…About 5-20% of adult-onset asthma cases are work-related occupational asthma (OA) [7,8]. More than 300 causative agents in OA have been identified and can be classified into high-molecular -weight (≥ 5000 g/mol) proteins of vegetal or animal origin, or low-molecular-weight (LMW) chemicals [9,10]. OA eosinophilic inflammation is a feature of asthma caused by high-molecular-weight proteins, but in LMW OA, which involves a poor steroid response, the neutrophilic inflammatory response is crucial [11].…”

Section: Introductionmentioning

confidence: 99%

Asthma Case Cluster during Renovation of a Water-Damaged and Toxic Building

Hyvönen¹,

Syrjälä

2019

Microorganisms

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Background: An association between fungal exposure at work and asthma onset has been shown, but a causal relationship between them has not beTanle en established. Methods: The study describes an asthma cluster in workers in a building under renovation. Before renovation the work site had significant water damage, technical deficiencies, and ventilation problems. Worker protection was insufficient during renovation. In the building, toxicity was determined from dust as well as from cultured dust. Toxicity analysis was conducted in vitro using the boar spermatozoa motility assay. Results: During the 8-month renovation period, among 290 workers, 21 (7.2%) experienced new-onset asthma (9 women, 42.9%; 12 men, 57.1%; median age, 43 years (range, 30–60 years)). At the renovation site, they had been exposed to areas where remarkable toxicity was demonstrated in vitro. One year later, 13 (61.9%) of them still had moderate disease, and three (14.8%) had severe disease. Most patients had a poor response to inhaled corticosteroids. Conclusions: This study documents a clear temporal association between occupational exposure during renovation of a water-damaged building and a cluster of 21 new occupational asthma cases. In addition, dust and cultured dust from their work spaces showed remarkable toxicity based on inhibition of boar sperm motility in vitro.

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Are high‐ and low‐molecular‐weight sensitizing agents associated with different clinical phenotypes of occupational asthma?

Abstract: This large cohort study describes distinct phenotypic profiles in OA caused by HMW and LMW agents. There is a need to further explore differences in underlying pathophysiological pathways and outcome after environmental interventions.

Cited by 82 publications

References 38 publications

Occupational Asthma Caused by Powder Paint in the Automotive Industry

Occupational Asthma Caused by Powder Paint in the Automotive Industry

Sudan red dye: a new agent causing type-2 occupational asthma

Asthma Case Cluster during Renovation of a Water-Damaged and Toxic Building

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