Are heart rate dynamics in the transition from rest to submaximal exercise related to maximal cardiorespiratory responses in COPD?

Mazzuco, Adriana; Medeiros, Wladimir Musetti; Souza, Aline; Alencar, Maria Clara; Neder, J. Alberto; Borghi‐Silva, Audrey

doi:10.1016/j.bjpt.2017.05.002

Cited by 7 publications

(4 citation statements)

References 36 publications

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“…Consistent with previous studies, cardiac AD exists regardless of the severity of COPD [39]. Considering its predictive value for quality of life and mortality [40,41], we suggest that physicians pay attention to exercise tolerance during the clinical management of patients with AD. These patients may not experience su cient relief from typical COPD treatment symptoms.…”

Section: Discussionsupporting

confidence: 86%

Chronotropic Incompetence and Abnormal Heart Rate Recovery in COPD: Relationship with Pulmonary Vascular Volume and Ventilatory Efficiency

Peng

Qumu

Huang

et al. 2023

Preprint

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Background: Cardiac automatic dysfunction (AD) is an established predictor of long-term mortality in patients with cardiopulmonary disease. It has been closely linked to lung blood perfusion abnormalities in pulmonary hypertension, a phenomenon that has been poorly studied in chronic obstructive pulmonary disease (COPD). This study aimed to 1) characterize computed tomography (CT), spirometry, and cardiopulmonary exercise test (CPET) features of COPD patients with cardiac AD; and 2) estimate the association of AD with CT-derived vascular and CPET-derived ventilatory efficiency metrics. Methods: Patients were randomly recruited and underwent clinical evaluation, spirometry, CPET, and CT. Cardiac AD was determined based on chronotropic incompetence (CI) or delayed heart rate recovery (HRR) during CPET. Results: Among 46 patients included in the study, CI was observed in 59% and delayed HRR was present in 35%. According to multivariate analyses, patients with CI were more likely to have reduced vascular volume (VV; VV < median; odds ratio [5–95% confidence interval], 4.82 [1.17–19.80]) and low ventilatory efficiency (nadir VE/VCO2 > median ; odds ratio [5–95% confidence interval], 6.89 [1.57–30.20]). Similar results were found for delayed HRR (VV < median; odds ratio [5–95% confidence intervals], 13.45 [1.95–92.85], nadir VE/VCO2 > median; odds ratio [5–95% confidence interval], 12.33 [1.56–97.30]). Conclusions: Cardiac AD is associated with increased pulmonary vascular volume and ventilatory efficiency. Findings suggest that lung blood perfusion abnormalities may occur in these patients, a result that requires confirmation via the assessment of a large population-based cohort.

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Section: Discussionsupporting

confidence: 86%

Chronotropic Incompetence and Abnormal Heart Rate Recovery in COPD: Relationship with Pulmonary Vascular Volume and Ventilatory Efficiency

Peng

Qumu

Huang

et al. 2023

Preprint

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“…Our second hypothesis was that there would be a relationship between HRV values before, during and after the test. Previously, there were studies that monitor HRV changes before and after the test (Fortes, et al, 2017) or after the test (Mazzuco, et al, 2017). In our study, short-time and ultra-shorttime HRV changes were observed before, during and after the four different physical fitness tests .…”

Section: Discussionsupporting

confidence: 58%

Non-invasive assessment of short and ultra-short heart rate variability during different physical and physiological tests

ALPARSLAN

Arabacı

Gorgulu

2021

Kinesiology (Zagreb, Online)

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The main aim of the present study was to determine the short- and ultra-short-term heart rate variability (HRV) during different physical and physiological tests and to compare HRV to different performance levels. The latter aim was to compare participants’ short- and ultra-short-term heart rate variability before-during-post-tests. Our hypothesis was that there would be a significant difference between test performance and HRV parameters, and the high performing group would have significantly higher HRV parameters than the low performing group. Fifty-three healthy men (Mage=26.9±4 years, Mheight=177.9±5.7 cm; Mweight =77.8±8.7 kg) were recruited in the current study. We completed the data collection procedure for each participant in four consecutive days. On day-1, anthropometric measurements were conducted and then participants performed isokinetic tests. On day-2, participants performed anaerobic tests; on day-3 equilibrium tests, and on day-4 aerobic capacity tests. The HRV records of all participants were obtained before, during and after all these tests. Based on the participants’ performance, they were divided into two groups: participants in G1 had lower performance and those in G2 higher performance. A two-way repeated measures ANOVA yielded significant differences in HRV values obtained in the four different tests. There was a significant difference between fitness test performance and the variation of short- and ultra-short-term HRV parameters. Also, significant differences in HRV values before, during, and after the testing were observed.

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“…Cardiac AD exists regardless of the severity of COPD and has predictive value for quality of life and mortality; we suggest physicians pay attention to it during clinical management [ 36 – 38 ]. These patients may not experience sufficient symptom relief from typical COPD treatment.…”

Section: Discussionmentioning

confidence: 99%

Abnormal heart rate responses to exercise in non-severe COPD: relationship with pulmonary vascular volume and ventilatory efficiency

Shi,

Qumu,

Wang

et al. 2024

BMC Pulm Med

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Background Despite being a prognostic predictor, cardiac autonomic dysfunction (AD) has not been well investigated in chronic obstructive pulmonary disease (COPD). We aimed to characterise computed tomography (CT), spirometry, and cardiopulmonary exercise test (CPET) features of COPD patients with cardiac AD and the association of AD with CT-derived vascular and CPET-derived ventilatory efficiency metrics. Methods This observational cohort study included stable, non-severe COPD patients. They underwent clinical evaluation, spirometry, CPET, and CT. Cardiac AD was determined based on abnormal heart rate responses to exercise, including chronotropic incompetence (CI) or delayed heart rate recovery (HRR) during CPET. Results We included 49 patients with FEV1 of 1.2–5.0 L (51.1–129.7%), 24 (49%) had CI, and 15 (31%) had delayed HRR. According to multivariate analyses, CI was independently related to reduced vascular volume (VV; VV ≤ median; OR [95% CI], 7.26 [1.56–33.91]) and low ventilatory efficiency (nadir VE/VCO2 ≥ median; OR [95% CI], 10.67 [2.23–51.05]). Similar results were observed for delayed HRR (VV ≤ median; OR [95% CI], 11.46 [2.03–64.89], nadir VE/VCO2 ≥ median; OR [95% CI], 6.36 [1.18–34.42]). Conclusions Cardiac AD is associated with impaired pulmonary vascular volume and ventilatory efficiency. This suggests that lung blood perfusion abnormalities may occur in these patients. Further confirmation is required in a large population-based cohort.

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Are heart rate dynamics in the transition from rest to submaximal exercise related to maximal cardiorespiratory responses in COPD?

Cited by 7 publications

References 36 publications

Chronotropic Incompetence and Abnormal Heart Rate Recovery in COPD: Relationship with Pulmonary Vascular Volume and Ventilatory Efficiency

Chronotropic Incompetence and Abnormal Heart Rate Recovery in COPD: Relationship with Pulmonary Vascular Volume and Ventilatory Efficiency

Non-invasive assessment of short and ultra-short heart rate variability during different physical and physiological tests

Abnormal heart rate responses to exercise in non-severe COPD: relationship with pulmonary vascular volume and ventilatory efficiency

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