Are goblet cell carcinoids a group of heterogeneous tumors?

Macák, J; Nemejcova, Kristina; Jana, Debarshi

doi:10.5507/bp.2017.027

Cited by 3 publications

(3 citation statements)

References 28 publications

(27 reference statements)

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“…With regard to immunohistochemistry, CEA expression appears to be the predominant differentiator, present in GCA but not in appendiceal NEN ( 68 , 100 ). There was variable expression of the neuroendocrine markers insulinoma-associated protein 1 (INSM1), chromogranin, synaptophysin, and CD56 reported across studies ( 32 , 38 , 78 , 100 ).…”

Section: Resultsmentioning

confidence: 97%

“…Our review included 104 studies (Figure 1). These consisted of one meta-analysis (8), one systematic review (9), one prospective cohort study (10), 18 registry studies (2,3,(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26), 66 single or multicentre retrospective analyses (4,7,, four inter-user variability studies (91)(92)(93)(94), and 13 case series (95)(96)(97)(98)(99)(100)(101)(102)(103)(104)(105)(106)(107). A quantitative meta-analysis of the studies was precluded by significant heterogeneity in the nomenclature and data.…”

Section: Systematic Reviewmentioning

confidence: 99%

“…A commonly reported aetiopathogenic factor was the occurrence of Tumour Protein 53 mutation (33,45,79), which in one study was only found in poorly differentiated tumours, possibly suggesting that it is the cause of high-grade transformation (45). However, the presence of TP53 mutation was inconsistent between studies (68,75,100). Multiple authors reported no Epidermal growth factor receptor, BRAF (59), KRAS (41,42,59), or Adenomatous polyposis coli (APC) (41,42) mutations in GCA, suggesting that its molecular pathogenesis is significantly different from that of colorectal adenocarcinoma, although again this was not a unanimous finding (33,45).…”

Section: Pathology Immunohistochemistry and Geneticsmentioning

confidence: 99%

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Goblet Cell Adenocarcinoma of the Appendix: A Systematic Review and Incidence and Survival of 1,225 Cases From an English Cancer Registry

et al. 2022

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BackgroundGoblet cell adenocarcinoma (GCA) of the appendix is a rare and aggressive tumour with varying nomenclature and classification systems. This has led to heterogeneity in published data, and there is a lack of consensus on incidence, survival, and management.MethodsWe provide an overview of GCA with a comprehensive systematic review using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology and a retrospective analysis of all cases recorded in the English National Cancer Registration and Analysis Service database between 1995 and 2018. The Kaplan–Meier estimator was used to calculate overall survival, and Cox proportional hazards regression was used to identify prognostic factors.ResultsThe systematic review demonstrated an incidence of 0.05–0.3 per 100,000 per year among North American registry studies. The 1-, 3-, and 5-year survival rate was 95.5%, 85.9%–87.6%, and 76.0%–80.6%, respectively. Age, stage, and grade were identified as prognostic factors for survival. Our analysis included 1,225 cases. Age-standardised incidence was 0.0335 per year in 1995 and gradually rose to 0.158 per year in 2018. The 1-, 3-, and 5-year survival rate was 90.0% [95% confidence interval (95% CI): 85.4–94.0], 76.0% (95% CI: 73.8–80.9), and 68.6% (95% CI: 65.9–72.2), respectively. On univariate Cox regression analyses, female sex, stage, and grade were associated with worse overall survival. On multivariate analysis, only stage remained a statistically significant prognostic factor.ConclusionsGCA of the appendix is rare, but incidence is increasing. We report a lower incidence and survival than North American registry studies. Higher stage was associated with decreased survival. Further prospective studies are required to establish optimal management.

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Section: Resultsmentioning

confidence: 97%

Section: Systematic Reviewmentioning

confidence: 99%

Section: Pathology Immunohistochemistry and Geneticsmentioning

confidence: 99%

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Goblet Cell Adenocarcinoma of the Appendix: A Systematic Review and Incidence and Survival of 1,225 Cases From an English Cancer Registry

et al. 2022

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Immunohistochemistry features and molecular pathology of appendiceal neoplasms

Mikaeel

Young

Rico

et al. 2021

Critical Reviews in Clinical Laboratory Sciences

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The Enigma of Goblet Cell Tumors of the Appendix

Velthuysen¹,

Eeden²,

Carr³

2019

AJSP: Reviews and Reports

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The term goblet cell carcinoid was first proposed in 1974 by Subbuswamy et al for a rare tumor of the appendix. Since then, it has been debated whether these tumors should be regarded as adenocarcinomas or as neuroendocrine tumors. Research on these neoplasms has been hampered by their rarity and the low density of tumor cells. However, their particular morphology legitimates their classification as an entity specific for the appendix. In this review the morphology, immunohistochemical profile and differential diagnosis are discussed. Recent literature on grading and molecular profiling is reviewed. These data show that grading these tumors using their morphologic growth patterns is of prognostic value. At the molecular level, goblet cell tumors differ from other appendiceal neoplasms, colon carcinoma, and neuroendocrine tumors and share similarities with other neoplasms such as diffuse-type gastric carcinoma. Goblet cell carcinomas thus emerge as an interesting target in this era of genetic profiling.

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Are goblet cell carcinoids a group of heterogeneous tumors?

Cited by 3 publications

References 28 publications

Goblet Cell Adenocarcinoma of the Appendix: A Systematic Review and Incidence and Survival of 1,225 Cases From an English Cancer Registry

Goblet Cell Adenocarcinoma of the Appendix: A Systematic Review and Incidence and Survival of 1,225 Cases From an English Cancer Registry

Immunohistochemistry features and molecular pathology of appendiceal neoplasms

The Enigma of Goblet Cell Tumors of the Appendix

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