Are drug-eluting stents indicated in large coronary arteries? Insights from a multi-centre percutaneous coronary intervention registry

Yan, Bryan P.; Ajani, A.; New, Gishel; Duffy, Stephen J.; Farouque, Omar; Shaw, James A.; Sebastian, Martin; Lew, Robert; Brennan, A.; Andrianopoulos, Nick; Reid, Christopher M.; Clark, David

doi:10.1016/j.ijcard.2008.06.046

Cited by 18 publications

(11 citation statements)

References 43 publications

(47 reference statements)

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“…The inverse relationship between vessel size and restenosis rate following BMS implantation [26] may explain the equal efficacy between BMS and DES implants as reported in previous studies on large coronary artery lesions. A series of previous studies showed no significant differences in the rate of TLR and MACE between BMS and DES in patients requiring large coronary stents [15,[17][18][19]. However, follow-up periods in these studies seemed to be relatively short to support their conclusions, because the late catch-up phenomenon and very late stent thrombosis could occur more than 1 year after stent implantation.…”

Section: Discussionmentioning

confidence: 90%

“…Furthermore, many DES trials excluded patients with larger arteries. So far, there have been a few retrospective subgroup analyses or registries of large vessel stenting (≥ 3.5 mm) and only some studies have analyzed the clinical outcome of DES and BMS in large-size coronary arteries [15][16][17][18][19]. These studies didn't seem to conclusively address the problem.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Drug-Eluting vs. Bare-Metal Stents: Is it a Matter of Vessel Size?

Boussaada¹,

Hassine²,

Messaoud³

et al. 2017

J Clin Trials

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Drug-Eluting vs. Bare-Metal Stents: Is it a Matter of Vessel Size?

Boussaada¹,

Hassine²,

Messaoud³

et al. 2017

J Clin Trials

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“…7 Restenosis rates are quite low in large arteries after bare-metal stent (BMS) implantation. 3,8 -11 Steinberg et al 12 reported that patients treated with ≥3.5 mm DES and BMS had similar low incidence of MACE and target-lesion revascularization (TLR) and TVR in both groups, with no superiority of DES over BMS in this lesion.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Angiographic Outcomes of Drug‐Eluting Stents in Patients With Large Vessel and Single Coronary Artery Lesion

Kim

Seol

et al. 2010

Clinical Cardiology

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Background: The aim of this study was to evaluate and compare the clinical and angiographic outcomes of 3 drug-eluting stents (DES) in patients with large vessel diameter and single coronary artery lesions. Hypothesis: The efficacy of 3 DESs may be similar. Methods: A total of 411 consecutive patients who visited 3 university hospitals from June 2004 to December 2007 and had a single coronary lesion which was treated with the use of a DES that was 3.5 mm in diameter were enrolled in this study. Patients were divided into 3 stent groups: Paclitaxel-eluting stent (PES, n = 105), Sirolimus-eluting stent (SES, n = 259), and Zotarolimus-eluting stent (ZES, n = 47). The study end point was a composite of major adverse cardiac events (MACE) including cardiac death, myocardial infarction (MI), and ischemia-driven target-vessel revascularization (TVR) for 12 months. Results: Baseline characteristics were not different. Late loss was higher in the ZES group than the other stents (0.5 ± 0.4 mm in SES vs 0.3 ± 0.5 mm in PES, 0.7 ± 0.5 mm in ZES, P = 0.001). The total MACE-free survival rate was not significantly different between the SES group and the PES group (98.8% in SES vs 97.1% in PES, P = 0.252) or the PES group and the ZES group (97.1% in PES vs 93.6% in ZES, P = 0.301). However, the SES group showed a significantly better MACE-free survival rate compared with the ZES group (98.8% in SES vs 93.6% in ZES, P = 0.018). Conclusions: Clinical and angiographic outcomes of DES in a large vessel diameter and single coronary artery is excellent and SES appears to show better angiographic and clinical outcomes than ZES. IntroductionDrug-eluting stents (DES) have shown great efficacy in the reduction of restenosis compared with bare-metal stents (BMS). 1 However, the advent of safety and cost concerns shakes the firm position of DESs in a wide range of coronary lesions and patient subsets. The benefits of DESs were confined to lesions <3.0 mm. 2 Although there were several randomized studies and other large registries comparing DES and BMS, 2 -5 no data was reported comparing the different DESs.We seek to evaluate and compare the clinical and angiographic outcomes of 3 different DESs in patients with large vessel diameter and single coronary artery lesion.

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“…To our opinion, this does not represent daily practice, as not every lesion (e.g. in large vessels) needs to be treated by a drug-eluting stent [18][19][20]. Therefore, in our registry about one fourth of all lesions received bare-metal stents.…”

Section: Follow-upmentioning

confidence: 93%

Single-centre all-comers registry reveals promising long-term clinical results of the Endeavor<sup>TM</sup>-Stent

Hertting¹,

Wieneke²,

Hausmann³

et al. 2012

WJCD

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Are drug-eluting stents indicated in large coronary arteries? Insights from a multi-centre percutaneous coronary intervention registry

Cited by 18 publications

References 43 publications

Drug-Eluting vs. Bare-Metal Stents: Is it a Matter of Vessel Size?

Drug-Eluting vs. Bare-Metal Stents: Is it a Matter of Vessel Size?

Clinical and Angiographic Outcomes of Drug‐Eluting Stents in Patients With Large Vessel and Single Coronary Artery Lesion

Single-centre all-comers registry reveals promising long-term clinical results of the Endeavor<sup>TM</sup>-Stent

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Are drug-eluting stents indicated in large coronary arteries? Insights from a multi-centre percutaneous coronary intervention registry

Cited by 18 publications

References 43 publications

Drug-Eluting vs. Bare-Metal Stents: Is it a Matter of Vessel Size?

Drug-Eluting vs. Bare-Metal Stents: Is it a Matter of Vessel Size?

Clinical and Angiographic Outcomes of Drug‐Eluting Stents in Patients With Large Vessel and Single Coronary Artery Lesion

Single-centre all-comers registry reveals promising long-term clinical results of the Endeavor&lt;sup&gt;TM&lt;/sup&gt;-Stent

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Product

Resources

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Single-centre all-comers registry reveals promising long-term clinical results of the Endeavor<sup>TM</sup>-Stent