Background
Leg length inequality is common in the general population and may accelerate development of knee osteoarthritis.
Objective
To determine if leg length inequality is associated with prevalent, incident and progressive knee osteoarthritis,
Design
Prospective observational cohort study.
Setting
Subjects recruited from the community in Birmingham, AL and Iowa City, IA
Patients
3026 subjects, age 50-79, with or at high risk for knee osteoarthritis.
Measurements
The exposure was leg length inequality measured from full limb radiographs. The outcomes were prevalent, incident, and progressive knee osteoarthritis. Radiographic osteoarthritis was defined as Kellgren and Lawrence grade ≥2 and symptomatic osteoarthritis was defined as radiographic disease in a consistently painful knee.
Results
Leg length inequality ≥1 cm was associated with prevalent radiographic (53% vs. 36%, OR 1.9, 95%CI 1.5-2.4) and symptomatic (30% vs. 17%, OR 2.0, 95%CI 1.6-2.6) osteoarthritis in the shorter limb. Inequality ≥1 cm was associated with incident symptomatic osteoarthritis in the shorter (15% vs. 9%, OR 1.7, 95%CI 1.2-2.4) and longer (13% vs. 9%, OR 1.5, 95%CI 1.0-2.1) limb. Inequality ≥1 cm was associated with increased odds (29% vs. 24%, OR 1.3, 95%CI 1.0-1.7) of progressive osteoarthritis in the shorter limb.
Limitations
The duration of follow-up may not be long enough to adequately identify cases of incidence and progression. Measurements of leg length, including radiographic, have measurement error which could result in misclassification.
Conclusions
Radiographic leg length inequality was associated with prevalent, incident symptomatic and progressive knee osteoarthritis. These results point to leg length inequality as a potentially modifiable risk factor for knee osteoarthritis.
Primary Funding Source
National Institute on Aging