Are Dietary Antioxidant Intake Indices Correlated to Oxidative Stress and Inflammatory Marker Levels?

Luu, Hung N.; Wen, Wanqing; Li, Honglan; Dai, Qi; Yang, Gong; Cai, Qiuyin; Xiang, Yong‐Bing; Gao, Yu‐Tang; Wang, Zheng; Shu, Xiao‐Ou

doi:10.1089/ars.2014.6212

Cited by 74 publications

(53 citation statements)

References 9 publications

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“…A few approaches exist to determine the effect of dietary antioxidant intake and its relation to OS, as reviewed by Luu et al [ 302 ]. These typically attempt to determine the intake of an array of dietary antioxidants, most often by FFQs.…”

Section: Markers Of Os Relation To Disease and Practical Aspectsmentioning

confidence: 99%

Common and Novel Markers for Measuring Inflammation and Oxidative Stress Ex Vivo in Research and Clinical Practice—Which to Use Regarding Disease Outcomes?

Menzel¹,

Samouda

Dohet³

et al. 2021

Antioxidants

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Many chronic conditions such as cancer, chronic obstructive pulmonary disease, type-2 diabetes, obesity, peripheral/coronary artery disease and auto-immune diseases are associated with low-grade inflammation. Closely related to inflammation is oxidative stress (OS), which can be either causal or secondary to inflammation. While a low level of OS is physiological, chronically increased OS is deleterious. Therefore, valid biomarkers of these signalling pathways may enable detection and following progression of OS/inflammation as well as to evaluate treatment efficacy. Such biomarkers should be stable and obtainable through non-invasive methods and their determination should be affordable and easy. The most frequently used inflammatory markers include acute-phase proteins, essentially CRP, serum amyloid A, fibrinogen and procalcitonin, and cytokines, predominantly TNFα, interleukins 1β, 6, 8, 10 and 12 and their receptors and IFNγ. Some cytokines appear to be disease-specific. Conversely, OS—being ubiquitous—and its biomarkers appear less disease or tissue-specific. These include lipid peroxidation products, e.g., F2-isoprostanes and malondialdehyde, DNA breakdown products (e.g., 8-OH-dG), protein adducts (e.g., carbonylated proteins), or antioxidant status. More novel markers include also –omics related ones, as well as non-invasive, questionnaire-based measures, such as the dietary inflammatory-index (DII), but their link to biological responses may be variable. Nevertheless, many of these markers have been clearly related to a number of diseases. However, their use in clinical practice is often limited, due to lacking analytical or clinical validation, or technical challenges. In this review, we strive to highlight frequently employed and useful markers of inflammation-related OS, including novel promising markers.

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Section: Markers Of Os Relation To Disease and Practical Aspectsmentioning

confidence: 99%

Common and Novel Markers for Measuring Inflammation and Oxidative Stress Ex Vivo in Research and Clinical Practice—Which to Use Regarding Disease Outcomes?

Menzel¹,

Samouda

Dohet³

et al. 2021

Antioxidants

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“…Although there are associations between regular intake of certain vitamins and trace elements and lower hsCRP concentrations (Scheurig, Thorand, Fischer, Heier, & Koenig, 2008), from our results in the present study, it appears that regular intake of antioxidants (vitamins A, C, and E; selenium; and zinc) was not associated per se with serum hsCRP levels. Additionally, in a previous study conducted in a large population of healthy Chinese women, results showed a lack of associations between dietary antioxidant scores (DAQs and CDAI) and serum hsCRP levels (Luu et al, 2015). This evidence could explain why, though DAQs can be a potential tool for assessing associations of dietary anti-inflammatory capacity with certain biomarkers, serum hsCRP levels do not seem to be influenced by dietary antioxidant intake.…”

Section: Discussionmentioning

confidence: 95%

“…The dietary antioxidant quality score (DAQs) was used to analyze antioxidant nutrient intake (Tur, Serra-Majem, Romaguera, & Pons, 2005). To estimate DAQs, we assessed the consumption of vitamins A, C, and E; selenium; and zinc (De Franca, Camargo, Lazaretti-Castro, & Martini, 2013; Luu et al, 2015; Rivas et al, 2012). The daily nutrient intake of each was compared to the recommended daily intake (RDI) for the Spanish population ( “ Ingestas Dietéticas de Referencia [IDR] para la Población Española, ” 2010).…”

Section: Methodsmentioning

confidence: 99%

Diet Quality and High-Sensitivity C-Reactive Protein in Patients With Systemic Lupus Erythematosus

Pocovi-Gerardino

Correa‐Rodríguez

Rubio

et al. 2018

Biological Research For Nursing

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Background and Aims: C-reactive protein (CRP) is commonly used as a biomarker for inflammation. Mild elevations of CRP have been seen in chronic autoimmune diseases like systemic lupus erythematosus (SLE), and CRP has been linked to an increased risk of cardiovascular events. Diet quality and certain dietary factors seem to influence CRP levels in healthy subjects. To date, the effect of diet on serum CRP in SLE has not been studied. Our aim was to investigate the relationship between dietary nutrients, antioxidant intake, and serum CRP in SLE. Design and Method: A cross-sectional study was conducted among 91 patients with SLE. High-sensitivity hsCRP values were determined using an immuno-turbidimetry assay in a Beckman Coulter analyzer (AU5800). Dietary intake of macro- and micronutrients was assessed through a 24-hr diet recall. Antioxidant nutrient intake was evaluated using the dietary antioxidant quality score (DAQs). Linear regression models were used to investigate the relationships between serum hsCRP levels, dietary nutrient intake, and DAQs. Results: The mean serum hsCRP level observed (3.76 ± 6.68 mg/L) was above the established normal range. However, participating SLE patients had low-quality diets, and we found no significant correlations between dietary intake of macro- or micronutrients or antioxidant nutrient intake (DAQs) and serum CRP levels. Conclusion: Our study reveals that participating SLE patients had a low-quality diet that did not influence inflammatory status measured using serum CRP levels. Further interventional studies with high-quality diets in this population are necessary to dissect the role of diet on CRP levels in SLE.

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“…We standardized each of the same six dietary vitamins and minerals by subtracting the global mean and dividing the result by the global standard deviation to estimate DAI. We then calculated the DAI by summing up the standardized intakes of these vitamins and minerals and equal weight, as described next [ 27 , 28 , 33 ]: …”

Section: Methodsmentioning

confidence: 99%

“…Thus, Dietary Antioxidant Index (DAI) was designed to examine the diet's entire antioxidant content. This index has been used in some studies, and significant results have been observed [27][28][29]. The DAI posits that people's diets can be divided into two major categories: mainly anti-oxidative or mainly oxidative [27].…”

Section: Introductionmentioning

confidence: 99%

Validation of Dietary Antioxidant Index (DAI) and investigating the relationship between DAI and the odds of gastric cancer

2020

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Background Gastric cancer (GC) incidence and mortality are rapidly growing worldwide. It is estimated that more than 1,000,000 new cases are diagnosed each year, and more than 78,000 people lose their lives due to GC. The association between dietary antioxidants and GC has been shown in some studies. However, because of the discrepancy between the findings and the lack of a valid indicator, it seems necessary to design and validate the Dietary Antioxidant Index (DAI) to examine the diet's total antioxidant content. The present study aimed to survey the validity of DAI and its association with the odds of GC. Methods In this hospital-based case–control study, 82 patients with GC and 95 healthy controls were examined. We used a 168-item food frequency questioner to assess dietary intakes. The DAI was calculated based on the intake of vitamin A, C, E, and selenium, manganese, and zinc. We standardized each of the six vitamins and minerals by subtracting the global mean and dividing by the global standard deviation to calculate DAI. We then calculated the DAI by summing up the standardized intakes of these vitamins and minerals of the individuals with equal weight. Results We observed a significant correlation between DAI and total antioxidant capacity (TAC) after controlling for age, body mass index (BMI), energy intake, smoking and fasting blood sugar, education, total fat intake, helicobacter pylori infection, total cholesterol, and saturated fatty acid (SFA) intakes. Results obtained from modeling DAI as a continuous variable in relation to GC showed a negative association after adjustment for age and in the multivariable analysis (OR = 0.64, CI = 0.43–0.95). Conclusion DAI is a valid indicator of dietary antioxidants assessments, and it can be used as a predictor of antioxidant status due to its correlation with serum antioxidant levels. The results showed that dietary antioxidants have a significant relationship with GC, which indicates the importance of antioxidants in this cancer's etiology.

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Are Dietary Antioxidant Intake Indices Correlated to Oxidative Stress and Inflammatory Marker Levels?

Cited by 74 publications

References 9 publications

Common and Novel Markers for Measuring Inflammation and Oxidative Stress Ex Vivo in Research and Clinical Practice—Which to Use Regarding Disease Outcomes?

Common and Novel Markers for Measuring Inflammation and Oxidative Stress Ex Vivo in Research and Clinical Practice—Which to Use Regarding Disease Outcomes?

Diet Quality and High-Sensitivity C-Reactive Protein in Patients With Systemic Lupus Erythematosus

Validation of Dietary Antioxidant Index (DAI) and investigating the relationship between DAI and the odds of gastric cancer

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