Are CVD Patients Under Oxidative Stress?

Dotan, Yedidya; Lichtenberg, Dov; Pinchuk, Ilya

doi:10.5772/28181

Cited by 3 publications

(7 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hydroxyl radicals (HO • ), highly reactive oxidant, represent the most efficient reactive oxygen species to abstract hydrogen and initiate a chain reaction for LP [3]. Once free radicals are formed, LP progresses and, as a consequence, several secondary toxic-oxidation products, including formaldehyde, acetaldehyde, malonaldehyde, and glyoxal, are formed [4]. Such secondary reaction products likely promote adverse effects in biological systems.…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress inhibition and oxidant activity by fibrous clays

Cervini-Silva

Nieto‐Camacho

Gómez‐Vidales

2015

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Oxidative stress inhibition and oxidant activity by fibrous clays

Cervini-Silva

Nieto‐Camacho

Gómez‐Vidales

2015

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

“…Furthermore, the GA effects were not gender‐specific and did not correlate with other parameters (Table ). Dotan et al . analyzed correlations between a variety of antioxidant markers which are commonly used in human studies and came to the conclusion that the correlations between different groups of these parameters are generally poor.…”

Section: Discussionmentioning

confidence: 99%

Gallic Acid Improves Health‐Associated Biochemical Parameters and Prevents Oxidative Damage of DNA in Type 2 Diabetes Patients: Results of a Placebo‐Controlled Pilot Study

Ferk

Kundi

Brath³

et al. 2018

Molecular Nutrition Food Res

View full text Add to dashboard Cite

show abstract

“…angina pectoris (SAP) are not different from matched controls, whereas unstable angina pectoris (UAP) patients have significantly higher MDA concentrations than both healthy controls and patients with SAP [49]. The observed differences between the different groups can not be taken as evidence that CVD patients are under oxidative stress, particularly because even the data based on MDA measurements is questionable due to: 1) the (questionable) reliability of the laboratory assay of MDA and 2) publication bias.…”

Section: Are Cvd Patients Under Os?mentioning

confidence: 96%

“…Figure 1 depicts the results of meta-analyses of the difference between the OS biomarkers in CVD patients and healthy people, as evaluated on the basis of different assays. The clear result is that the available data exhibit significant differences only when OS was estimated on the basis of the level of MDA [49]. Interestingly, the MDA concentrations in patients with stable 8-OH-dG (1) MDA (13) LOOH (1) Isoprostanes (2) Vitamin E (7) Vitamin C (5) Carotenes (1) Urate (2) GSH (2) SOD (3) GPX (5) CAT (1) TEAC (2) Lag time (4) Max Ox Rate (1)…”

Section: Are Cvd Patients Under Os?mentioning

confidence: 99%

See 1 more Smart Citation

Atherogenesis, the oxidative LDL modification hypothesis revisited

Lichtenberg¹,

Pinchuk²

2013

ABB

Self Cite

View full text Add to dashboard Cite

The commonly-accepted "oxidized LDL hypothesis of atherogenesis" is based on a large number of indirect evidence that shows that oxidatively-modified LDL plays a role in atherogenesis. Yet, the exact role is not clear. Some researchers think that oxidatively modified biomolecules initiate atherogenesis; others believe that they "only" promote this multifactorial process. Regardless of the exact mechanism responsible for the effect of peroxidation on atherogenesis, the "oxidative theory of AS" is apparently inconsistent with the results of meta-analysis, in which (the "expected") significant correlation between CVD and oxidative stress (OS) was found only when the OS was evaluated on the basis of the plasma concentrations of malondialdehyde (MDA), often based on the concentration of thiobarbituric acid reactive substances (TBARS). Notably, even this association is questionable due to 1) poor reliability of the laboratory assay of MDA and 2) possible publication bias. Hence, it appears that the commonly accepted paradigm regarding the role of oxidative damage in the pathogenesis of CVD has been overestimated. Furthermore, the hypothesis is apparently inconsistent with the disappointing results of most of the clinical trials that were designed to reduce OS by means of supplementation of antioxidants, mostly vitamin E. These apparent inconsistencies do not contradict the oxidative modification hypothesis of AS. The source of the apparent contradictions is probably the oversimplified considerations on which the predictions have been based. Many reasonable arguments can be raised to explain the apparent contradictions, which means that our current knowledge is insufficient to test the relationship of oxidative stress to cardiovascular disease.[85] Tynkkynen, T., Mursu, J., Nurmi, T., Tuppurainen, K., Laatikainen, R. and Soininen, P. (2012) NMR protocol for determination of oxidation susceptibility of serum lipids and application of the protocol to a chocolate study. Metabolomics,8,[386][387][388][389][390][391][392][393][394][395][396][397][398]

show abstract

Are CVD Patients Under Oxidative Stress?

Cited by 3 publications

References 62 publications

Oxidative stress inhibition and oxidant activity by fibrous clays

Oxidative stress inhibition and oxidant activity by fibrous clays

Gallic Acid Improves Health‐Associated Biochemical Parameters and Prevents Oxidative Damage of DNA in Type 2 Diabetes Patients: Results of a Placebo‐Controlled Pilot Study

Atherogenesis, the oxidative LDL modification hypothesis revisited

Contact Info

Product

Resources

About