Are Cure Rates for Breast Cancer Improved by Local and Regional Anesthesia?

Tsigonis, Abraham M.; Al-Hamadani, Mohammed; Linebarger, Jared H.; Vang, Choua A; Krause, Forrest J.; Johnson, James C.; Marchese, Edward; Marcou, Kristen A.; Hudak, Jane; Landercasper, Jeffrey

doi:10.1097/aap.0000000000000379

Cited by 31 publications

(21 citation statements)

References 28 publications

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“…Starnes-Ott et al 14 found that the recurrence rate in the volatile GA-opioid group was 1.4 per 100 000 person-days and 2.6 per 100 000 person-days in the PVB-GA group. In agreement with that study, Tsigonis et al 16 concluded that the OS, DFS, and local regional recurrence were not significantly different between women who received GA or local regional anesthesia. Lastly, Cata et al 17 showed similar RFS and OS estimates in women with and without PVB, despite demonstrating a significant reduction in the use of opioids on the PVB group.…”

Section: Discussionsupporting

confidence: 82%

Impact of Regional Anesthesia on Recurrence, Metastasis, and Immune Response in Breast Cancer Surgery

Pérez-González

Cuéllar-Guzmán

Soliz

et al. 2017

Regional Anesthesia and Pain Medicine

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Section: Discussionsupporting

confidence: 82%

Impact of Regional Anesthesia on Recurrence, Metastasis, and Immune Response in Breast Cancer Surgery

Pérez-González

Cuéllar-Guzmán

Soliz

et al. 2017

Regional Anesthesia and Pain Medicine

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“…Mean age of the patients was 54.1 ±2.41 (36-75). Excisional biopsy took 12.1±2.78 (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) minutes and sentinel lymph node biopsy took 15.5±3.73 (10-23) minutes after local anesthesia was applied. Average time between excisional biopsy and sentinel lymph node biopsy was 27.1±3 days.…”

Section: Resultsmentioning

confidence: 99%

Surgical Treatment of Early Breast Cancer Under Local Anesthesia

Beksaç¹,

Çetin²

2019

Acta Oncol Tur.

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Meme koruyucu cerrahinin lokal anestezi altında yapılabileceğini göstermek. YÖNTEM ve GEREÇLER: Ardışık 60 meme kanseri hastasına lokal anestezi altında meme koruyucu cerrahi uygulandı. Bütün hastalara lumpektomi ve sentinel lenf nodu biyopsisi uygulandı. Palpe edilemeyen lezyonlar tel ile işartelendi. Yapılan işlem detaylı bir şekilde açıklandı. BULGULAR: Eksizyonel biyopsi ve sentinel lenf nodu biyopsisi arası ortalama süre 27,1±3 gündü. 24 (%40) hastada telle işaretli biyopsi gerekli oldu. 51 (%85) hastada cerrahi lokal anestezi altında tamamlandı. 9 (%15) hastada sentinel lenf nodu biyopsisi tümör-pozitifti. Bu hastalara genel anestezi altında aksilla diseksiyonu yapıldı. Hiçbir hastanın lokal anesteziye intoleransı olmadı. TARTIŞMA ve SONUÇ: Lokal anestezi altında bariz bir şekilde hasta konforu sağladı. Bu sayede hastalar günübirlik cerrahide tedavi oldular ve genel anestezinin yan etkilerinden ve ekstra maliyetten kaçınılmış olundu. Bizim sonuçlarımız tekniğin yapılabilirliğinin güzel bir göstergesidir. Anahtar Kelimeler: Meme kanseri, meme koruyucu cerrahi, lokal anestezi, sentinel lenf nodu ABSTRACT INTRODUCTION: To show the viability of breast-conserving surgery under local anesthesia. MATERIAL and METHODS: 60 consecutive breast cancer patients treated with breast-conserving surgery under local anesthesia are reported in this study. Wide excisional biopsy and sentinel lymph node biopsy were performed in all patients. Wire-guided biopsy method was used in non-palpable lesions. Techniques used are described in detail. RESULTS: Average time between excisional biopsy and sentinel lymph node biopsy was 27.1±3 days. Wireguided excisional biopsy was the method of choice in 24 (40%) patients. In 51 of 60 (85%) patients, surgery was completed under local anesthesia. 9 (15%) patients' sentinel lymph node biopsy result was tumour-positive. These patients required axillary dissection under general anesthesia. None of the patients showed intolerance to surgery under local anesthesia. DISCUSSION AND CONCLUSION: Surgery under local anesthesia provides significantly better patient comfort as the patients can be handled in the outpatient clinic. Local anesthesia is free of side effects and extra costs of general anesthesia are avoided. Our report is a good addition to the literature supporting the viability of the technique.

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“…Anesthetic‐induced immunosuppression may differ between GA and local anesthesia/anesthetic sedation, and local anesthesia may reduce cancer recurrence and cancer‐related mortality. This difference may explain why previous retrospective studies on anesthetic techniques and cancer outcomes showed conflicting results in patients with breast cancer . Clinical trials are ongoing to compare different anesthetics in patients undergoing breast cancer surgery (NCT00418457; NCT02089178).…”

Section: Discussionmentioning

confidence: 99%

Outcomes of outpatient breast cancer surgery at a private breast clinic

Kim¹,

Kawai²,

Wakisaka³

et al. 2018

Breast J

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Advances in surgical and anesthetic techniques have allowed for outpatient treatment of breast cancer. We evaluated the feasibility, safety, efficacy, and surgical outcomes of outpatient surgery in 370 patients with breast cancer who underwent breast-conserving surgery (BCS)/axillar lymph node (ALN) management. There were no deaths or severe intraoperative complications, but 41 complications were observed and disease recurrence occurred in 18 patients. The cumulative overall survival rate was 95.2%. Outpatient surgery was well tolerated, feasible, and safe in patients receiving BCS/ALN management.

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Are Cure Rates for Breast Cancer Improved by Local and Regional Anesthesia?

Cited by 31 publications

References 28 publications

Impact of Regional Anesthesia on Recurrence, Metastasis, and Immune Response in Breast Cancer Surgery

Impact of Regional Anesthesia on Recurrence, Metastasis, and Immune Response in Breast Cancer Surgery

Surgical Treatment of Early Breast Cancer Under Local Anesthesia

Outcomes of outpatient breast cancer surgery at a private breast clinic

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