Are congenital malformations more frequent in fetuses with intrahepatic persistent right umbilical vein? A comparative study

Adiego-Calvo, Ignacio; Savirón-Cornudella, Ricardo; Martínez‐Payo, C.; Aranda, Encarnación Rubio; Sancho-Saúco, Javier; Cisneros-Gimeno, Ana Isabel; Pérez-Pérez, Pilar; Lerma-Puertas, Diego; Whyte-Orozco, Jaime

doi:10.1016/j.tjog.2015.12.022

Cited by 11 publications

(21 citation statements)

References 14 publications

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“…The most common anomalies in PRUV fetuses were cardiovascular system anomalies, followed by nervous system, urinary system, skeletal, and other anomalies. Similar to our study, Adiego-Calvo et al 6 found a statistically signi cant association between isolated PRUV and the presence of congenital malformations, but in their series, only malformations of the genitourinary system showed this positive association. The difference in sample size may be the main reason for the different results.…”

Section: Discussionsupporting

confidence: 91%

“…PRUV can appear in isolation or concomitantly with anomalies in other systems. Our study shows that approximately 13.5% of PRUV fetuses have anomalies in other systems, similar to the concomitant malformation rate of 13% reported by Blazer et al 12 or 17.9% reported by Adiego-Calvo et al 6 , and was lower than the rate of 23.5-40.9% reported by other researchers. 1,2,9,10 The lower proportion of PRUV fetuses with concomitant anomalies observed in our study may be due to the following: rst, our study included cases at late gestation, while some fetuses with PRUV and concomitant serious anomalies might have been aborted during early or mid-gestation or had stopped growing in utero.…”

Section: Discussionsupporting

confidence: 83%

“…Several studies have shown detection rates similar to our rate of 0.17%. 1,6,8,12 Retrospective studies in Spain and Germany had lower detection rates of 0.1% and 0.08%. 2,10 Two studies showed much higher detection rates of 0.46% and 0.5%, but the authors have attributed this to the private system and referrals in one study and the prospective study design and small sample size in the other.…”

Section: Discussionmentioning

confidence: 98%

“…[2][3][4][5] As a result, PRUV occurs if the left umbilical vein atrophies and degenerates and the right umbilical vein is retained. 6 PRUV can be diagnosed during prenatal ultrasonography by examination of the transverse section of the fetal abdomen. In 1990, Jeanty rst reported the diagnosis of PRUV by prenatal ultrasonography.…”

Section: Introductionmentioning

confidence: 99%

“…1,2,6,8−12 In addition, most cases of PRUV do not include malformations in other systems, with a concomitant malformation rate of 13-40.9%. 1,2,6,9,10,12 Common malformations include cardiac, urinary, nervous, skeletal, and other malformations.…”

Section: Introductionmentioning

confidence: 99%

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Ultrasonic Detection of Fetal Persistent Right Umbilical Vein and Incidence and Significance of Concomitant Anomalies

Yuan

Ding

et al. 2020

Preprint

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Abstract Background: Persistent right umbilical vein (PRUV) is characterized by atresia of the left umbilical vein while the right umbilical vein remains open. Given the limited sample size of most studies, the incidence of PRUV and the status of concomitant anomalies may not be fully reflected. Thus, we studied the incidence of fetal PRUV and its concomitant anomalies on a larger scale using our hospital database. This study hoped to address the following questions: Does PRUV increase the risk of fetal anomalies? If the PRUV fetus also has a single umbilical artery (SUA), does the risk of fetal anomaly increase further? What is the positive predictive value of PRUV for fetal anomalies?Methods: This retrospective study analyzed 756 cases of fetal PRUV at our hospital from January 2007 to April 2017. Prenatal ultrasound and color Doppler images were assessed. All PRUV fetuses underwent echocardiography and detailed ultrasound examinations of other systems. Newborn status was obtained via the database or by telephone follow-up.Results: A total of 435,428 pregnant women underwent prenatal ultrasonography at 16–40 weeks, the incidence of fetal PRUV was 0.17%, and 102 fetuses (13.5%) developed other anomalies. Two complicated cases had trisomy 18. PRUV was associated with a higher incidence of fetal anomalies. When fetal anomalies were classified by body systems, PRUV was associated with a higher incidence of cardiovascular, nervous, urinary, skeletal, digestive, and respiratory system anomalies. The positive predictive values of a PRUV for any fetal anomalies and cardiovascular anomalies were 13.5% (95%CI, 11.2%–16.2%) and 5.4% (95%CI, 4.0%–7.3%), respectively. SUA further increases the risk of PRUV fetuses with other anomalies and cardiovascular anomalies.Conclusions: Detailed prenatal ultrasonography and echocardiography should be performed in fetuses with PRUV to rule out anomalies in other systems. When the PRUV is combined with SUA, echocardiography is particularly important. Fetuses with complicated PRUV should undergo chromosomal examination. Although isolated fetal PRUV prognosis is good, complicated PRUV prognosis depends on the type and severity of the concomitant anomalies.

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Section: Discussionsupporting

confidence: 91%