Are circadian rhythms new pathways to understand Autism Spectrum Disorder?

Geoffray, Marie‐Maude; Nicolas, Alain; Speranza, Mario; Guillaume, Nicolas

doi:10.1016/j.jphysparis.2017.06.002

Cited by 59 publications

(61 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This autoregulatory genetic feedback loop lasts 24 hours, with an accumulation of period and cryptochrome proteins in the cytoplasm during the subjective day and the degradation of period and cryptochrome heterodimers in the nucleus during the subjective night. The finding of an association between ASD and single‐nucleotide polymorphisms in PER1 , PER3 , and NPAS2 suggests that clock genes could be involved in the pathogenicity of ASD …”

Section: Biological Factors Predisposing Sleep Problems In Children Wmentioning

confidence: 99%

Sleep–behaviour relationship in children with autism spectrum disorder: methodological pitfalls and insights from cognition and sensory processing

Deliens

Peigneux

2019

Develop Med Child Neuro

View full text Add to dashboard Cite

Sleep disturbances are frequent and varied in autism spectrum disorder (ASD). Growing evidence suggests that sleep problems in children with ASD are driven by their clinical characteristics and psychiatric comorbidities. Therefore, the wide range of reported sleep disturbances reflects the marked heterogeneity of clinical pictures in ASD. Whether sleep disturbances and their various forms may, in turn, account for at least part of the phenotypical variability of ASD is a crucial question discussed in this review. We first outline studies both validating and challenging a bidirectional theoretical framework for sleep disorders in children with ASD. We then propose to extend this model by including cognition and sensory processing as key factors in the vicious circle linking sleep disorders and autistic symptoms. What this paper adds There is a bidirectional interplay between autism symptoms and sleep disturbances. Sleep influence on daytime cognitive and sensory skills should be further investigated.

show abstract

Section: Biological Factors Predisposing Sleep Problems In Children Wmentioning

confidence: 99%

Sleep–behaviour relationship in children with autism spectrum disorder: methodological pitfalls and insights from cognition and sensory processing

Deliens

Peigneux

2019

Develop Med Child Neuro

View full text Add to dashboard Cite

show abstract

“…It is noteworthy that only a few days of circadian rhythm impairments may impact the maturation and specialization of some brain structures at specific developmental periods; these abnormalities can alter the temporal organization of brain maturation and development [86];…”

Section: Relationships Between Circadian Rhythms and Psychiatric Dmentioning

confidence: 99%

Clock Genes and Altered Sleep–Wake Rhythms: Their Role in the Development of Psychiatric Disorders

Charrier

Olliac

Roubertoux

et al. 2017

IJMS

135

View full text Add to dashboard Cite

In mammals, the circadian clocks network (central and peripheral oscillators) controls circadian rhythms and orchestrates the expression of a range of downstream genes, allowing the organism to anticipate and adapt to environmental changes. Beyond their role in circadian rhythms, several studies have highlighted that circadian clock genes may have a more widespread physiological effect on cognition, mood, and reward-related behaviors. Furthermore, single nucleotide polymorphisms in core circadian clock genes have been associated with psychiatric disorders (such as autism spectrum disorder, schizophrenia, anxiety disorders, major depressive disorder, bipolar disorder, and attention deficit hyperactivity disorder). However, the underlying mechanisms of these associations remain to be ascertained and the cause–effect relationships are not clearly established. The objective of this article is to clarify the role of clock genes and altered sleep–wake rhythms in the development of psychiatric disorders (sleep problems are often observed at early onset of psychiatric disorders). First, the molecular mechanisms of circadian rhythms are described. Then, the relationships between disrupted circadian rhythms, including sleep–wake rhythms, and psychiatric disorders are discussed. Further research may open interesting perspectives with promising avenues for early detection and therapeutic intervention in psychiatric disorders.

show abstract

“…A variety of comorbidities are associated with ASD, including gastrointestinal disorders, epilepsy, or psychiatric illnesses, with sleep impairments being one of the most common ones (4). The prevalence of sleep disturbances in children with ASD is reported to be 50-80 %, compared to 9-50 % in typically developing children (5). In particular, short sleep duration, low sleep quality/effi ciency, circadian sleep desynchronisation and/or delayed sleep are the most commonly presented sleep disturbances (6).…”

Section: Introductionmentioning

confidence: 99%

“…During the night, melatonin concentrations increase several times with a peak in the middle of the night (9). Several studies revealed that a proportion of individuals with ASD have lower levels of melatonin (5), as well as that deviations in biorhythm of melatonin secretion were observed (6). Abnormalities in melatonin production have been associated with the severity of ASD impairments (10).…”

Section: Introductionmentioning

confidence: 99%

Urinary levels of 6-sulphatoxymelatonin and their associations with sleep disorders and behavioural impairments in children with autism spectrum disorder

Babinská¹,

Siklenková²,

Stebelová³

et al. 2019

BLL

View full text Add to dashboard Cite

BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental condition associated with sleep disturbances that may result from abnormalities in melatonin production. The correlations of melatonin levels with the severity of sleep disorder and/or severity of ASD were reported. OBJECTIVES: To evaluate urinary levels of the melatonin metabolite, 6-sulphatoxymelatonin (aMT6s), in children with ASD, and their associations with sleep abnormalities and behavioural impairments. METHODS: Study involved 77 children with ASD and 84 controls aged 2.5-15.5 years. Sleep disorders were assessed by Children's Sleep Habits Questionnaire. Morning and afternoon levels of aMT6s were determined by radioimmunoassay method. Urinary creatinine levels were assessed by an enzymatic method. RESULTS: The urinary aMT6s/creatinine values indicate that the night-time melatonin levels are signifi cantly lower in ASD than in controls, but there are no signifi cant differences in the daytime levels. In the ASD group, on average, a 6.8-fold difference between night-time and daytime values of urinary aMT6s/creatinine was found, whereas for the controls a 12.5-fold difference was observed, indicating a lower night-time increase in melatonin levels. In ASD group, the difference in night-time-daytime aMT6s/creatinine value correlated with some types of sleep problems, but not with the severity of ASD. CONCLUSION: The results indicate that in ASD there are differences in the patterns of melatonin secretion that may be associated with sleep impairment (Tab. 4, Fig. 2, Ref. 28).

show abstract

Are circadian rhythms new pathways to understand Autism Spectrum Disorder?

Cited by 59 publications

References 63 publications

Sleep–behaviour relationship in children with autism spectrum disorder: methodological pitfalls and insights from cognition and sensory processing

Sleep–behaviour relationship in children with autism spectrum disorder: methodological pitfalls and insights from cognition and sensory processing

Clock Genes and Altered Sleep–Wake Rhythms: Their Role in the Development of Psychiatric Disorders

Urinary levels of 6-sulphatoxymelatonin and their associations with sleep disorders and behavioural impairments in children with autism spectrum disorder

Contact Info

Product

Resources

About