Are certain factors involved in calcium metabolism associated with temporomandibular disorders?

Madani, Azamsadat; Shamsian, Seyed Aliakbar; Layegh, Parvin; Abrisham, Seyed Mohammad Jalil; Ravaghi, Ali; Najjaran, Niloufar Tayarani

doi:10.1080/08869634.2019.1596054

Cited by 7 publications

(14 citation statements)

References 38 publications

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“…In 2019, Madani et al published a study that aimed to identify whether among the multiple factors involved in calcium metabolism, vitamin D is associated with temporomandibular disorders [ 41 ]. A total of 51 patients with different types of TMDs were included in their study, who were compared with 29 healthy subjects.…”

Section: Current Status Of Knowledgementioning

confidence: 99%

Vitamin D and Temporomandibular Disorders: What Do We Know So Far?

et al. 2021

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Background and aims. Vitamin D is synthesized in the skin with the aid of ultraviolet-B radiation, playing a variety of roles in the body. Temporomandibular disorders (TMDs) are a group of pathological conditions involving the temporomandibular joints as well as the masticatory muscles and othersurrounding tissues. In the present narrative review, we investigated the potential role of vitamin D in the etiology of temporomandibular disorders in order todetermine whether the current knowledge supports 25-hidroxyvitamin D (25-OHD) supplementation in temporomandibular disorders associated with insufficient or deficient levels of vitamin D. Methods. A literature research was performed in PubMed, Scopus, Science Direct, and Google Scholar databases, and a total of 10 articles were included for analysis. Results.Among the observational studies published to date, investigating the role for vitamin D in the etiology of TMDs, six of them suggest that there is a connection between the two aspects. In this context, patients suffering from TMD, with deficient levels of vitamin D (<30 ng/mL), are most likely to benefit from supplementation, whereas individuals with vitamin D level >50ng/mL probably have little benefit from supplementation.Conclusion.Vitamin D might be a safe, simple, and potentially beneficial way to prevent TMDs or to reduce pain; however, more randomized and placebo-controlled trials are required before any firm conclusions can be drawn.

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Section: Current Status Of Knowledgementioning

confidence: 99%

Vitamin D and Temporomandibular Disorders: What Do We Know So Far?

et al. 2021

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“…The publication year of the studies that were included in this review ranged between 2017 [ 35 , 36 ] and 2022 [ 37 ]. The nationalities of the studies included in this review were as follows: seven studies (69%) were conducted in Asia (two in Iran [ 38 , 39 ], three in India [ 36 , 37 , 40 ], one in Iraq [ 35 ], and one in Korea [ 41 ]); one study (8%) was conducted in Europe (in Norway [ 42 ]); and the remaining three studies (23%) were Turkish [ 43 , 44 , 45 ].…”

Section: Resultsmentioning

confidence: 99%

“…Seven were cross-sectional studies [ 35 , 36 , 37 , 38 , 39 , 42 , 45 ], two had a prospective observational design [ 41 , 43 ], one was a prospective case-control study [ 44 ], and one study was a randomized controlled trial [ 40 ].…”

Section: Resultsmentioning

confidence: 99%

“…Seven papers [ 35 , 38 , 39 , 41 , 42 , 43 , 44 ] assessed the relationship between hypovitaminosis D and TMDs. In the study by Ahmed et al [ 35 ], TMD patients with rheumatoid arthritis were assessed.…”

Section: Resultsmentioning

confidence: 99%

“…In particular, a serious vitamin D deficiency was more prevalent in patients with a TMD ( p = 0.00001). Moreover, Demir et al [ 43 ] and Madani et al [ 38 ] did not report significant differences in the vitamin D serum levels between the TMD patients and the healthy subjects. In contrast, Staniszewski et al [ 42 ] showed that TMD patients had significantly higher serum levels of vitamin D ( p = 0.005) compared to the controls.…”

Section: Resultsmentioning

confidence: 99%

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Temporomandibular Disorders and Vitamin D Deficiency: What Is the Linkage between These Conditions? A Systematic Review

Ferrillo

Lippi

Giudice

et al. 2022

JCM

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Although a growing body of literature has been emphasizing the role of vitamin D in oral health, there is still a gap of knowledge regarding the correlation between temporomandibular disorders (TMDs) and vitamin D. Therefore, the aim of this systematic review was to assess the linkage between hypovitaminosis D and TMDs to map the current literature in this field. On 10 September 2022, PubMed, Scopus, and Web of Science databases were systematically searched from the date of their inception to identify the studies that had assessed patients with TMDs. The primary outcome assessed in this review was the relationship between hypovitaminosis D and TMDs. Out of the 329 studies identified, 13 studies met the eligibility criteria and were included in the present work. Seven studies assessed the relationship between vitamin D and TMDs, reporting that vitamin D serum levels are lower in patients with TMDs. Our results suggested that vitamin D receptor (VDR) polymorphisms might have a role in TMDs’ development. However, the quality assessed underlined that only one study did not present a serious risk of bias. Further good-quality studies are needed to clarify the linkage between vitamin D deficiency and TMDs, but the evidence currently available has suggested potential correlations.

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