Are centrilobular emphysema and panlobular emphysema two different diseases?

Mitchell, Roger S.; Silvers, G. Wayne; Goodman, Neal; Dart, G; Maisel, John C.

doi:10.1016/s0046-8177(70)80076-4

Cited by 28 publications

(12 citation statements)

References 11 publications

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“…As mentioned earlier, some workers have expressed serious reservations concerning the distinct natures of centrilobular emphysema and panlobular emphysema (Mitchell et al, 1970). Several factors have contributed to this.…”

Section: Discussonmentioning

confidence: 99%

“…A predilection of centrilobular emphysema for the lung apices has also been noted (Thurlbeck, 1963). The medical community has not been unanimous in accepting this concept of two basic forms of disease; typical reservations were expressed in a recent article (Mitchell et al, 1970). The purpose of the present study is to examine this problem by systematic sampling of lungs for differences in the distribution of these two types of emphysema.…”

mentioning

confidence: 95%

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Centrilobular emphysema and panlobular emphysema: two different diseases

Anderson

Foraker

1973

Thorax

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Section: Discussonmentioning

confidence: 99%

mentioning

confidence: 95%

Centrilobular emphysema and panlobular emphysema: two different diseases

Anderson

Foraker

1973

Thorax

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“…Dunnill (1969) considered that the typical appearance could always be recognized. A further difficulty is posed by the fact that many patients have both types of emphysema together (Laws and Heard, 1962;Thurlbeck, 1963;Gough, 1965), and serious disagreements between observers on the type present in a given lung are not uncommon (Thurlbeck et al, 1969;Mitchell et al, 1970). The latter authors attempted to make a distinction between the two types on the basis of clinical or physiological features.…”

Section: Discussionmentioning

confidence: 99%

“…A precise classification is, however, difficult in many cases (Thurlbeck et al, 1969;Mitchell et al, 1970), and not all authors agree about the clinical, radiological, and physiological features, particularly of centrilobular emphysema (Sweet, Wyatt, Fritsch, and Kinsella, 1961 ;Snider, Brody, and Doctor, 1962;Reid, 1967;Thurlbeck, Henderson, Fraser, and Bates, 1970). In one type of emphysema, however, that associated with al-antitrypsin deficiency, there seems little doubt that the lower zones are predominantly affected (Eriksson, 1965;Guenter et al, 1968;Hutchison et al, 1971).…”

mentioning

confidence: 99%

Radiological distribution of pulmonary emphysema: Clinical and physiological features of patients with emphysema of upper or lower zones of lungs

Martelli

Hutchison

Barter

1974

Thorax

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“…5 and 6). Controversy exists concerning the distinction between centrilobular emphysema and panacinar emphysema-some believe them to be distinctly different diseases (Anderson and Foraker,T973); others believe them to have the same associations (Mitchell et al, 1970). The reason for the disagreement will be discussed below.…”

Section: Panacinar Emphysemamentioning

confidence: 97%

The pathobiology and epidemiology of human emphysema

Thurlbeck

1984

Journal of Toxicology and Environmental Health

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Emphysema is defined in anatomical terms as enlargement of the gas-exchanging part of the lung (the acinus) accompanied by destruction of respiratory tissue. Emphysema is classified by the way that the acinus is dominantly involved. In proximal acinar emphysema, the proximal part of the acinus-respiratory bronchioles-is dominantly involved and two forms of proximal acinar emphysema are usually recognized: centrilobular emphysema and simple pneumoconiosis of coalworkers. The acinus is more or less uniformly involved in panacinar emphysema, and several clinical associations have been described with this lesion. In distal acinar emphysema, alveolar ducts and sacs are particularly involved, and spontaneous pneumothorax of young adults is associated with this form of emphysema. Scarring is usually associated with irregular involvement of the acinus (irregular emphysema) and is usually asymptomatic. No uniform agreement exists as to the application of this classification and there is widespread discrepancy of classification of emphysematous lungs between experts, especially when emphysema is severe. The precise definition of destruction of respiratory tissue in emphysema has not been agreed on, and this had led to wide variations in the assessment of prevalence of emphysema in autopsy series. Tobacco smoking is the most important cause of emphysema and is thought to bring it about by imbalance between the protease-antiproteinase mechanisms in the lung. Increasing severity of emphysema is accompanied by increasing frequency of symptoms, but a substantial proportion of subjects with severe emphysema will be apparently free from symptoms. The major functional characteristics of severe emphysema are reduction in expiratory flow, increase in lung volumes, and diminished diffusing capacity. Diminished expiratory flow in emphysema is determined in part by loss of elastic recoil and in part by associated airway disease. Loss of recoil in emphysematous lungs may be brought about by functional changes in the apparently normal intervening lung between the emphysematous spaces.

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Are centrilobular emphysema and panlobular emphysema two different diseases?

Cited by 28 publications

References 11 publications

Centrilobular emphysema and panlobular emphysema: two different diseases

Centrilobular emphysema and panlobular emphysema: two different diseases

Radiological distribution of pulmonary emphysema: Clinical and physiological features of patients with emphysema of upper or lower zones of lungs

The pathobiology and epidemiology of human emphysema

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