Are central and systemic inflammation associated with fatigue in cerebral small vessel disease?
Amy A Jolly,
Robin B Brown,
Daniel J Tozer
et al.
Abstract:Background Fatigue is a common symptom in cerebral small vessel disease (SVD), but its pathogenesis is poorly understood. It has been suggested that inflammation may play a role. We determined whether central (neuro) inflammation and peripheral inflammation were associated with fatigue in SVD. Methods 36 patients with moderate to severe SVD underwent neuropsychometric testing, combined PET-MRI and blood draw for analysis of inflammatory blood biomarkers. Microglial signal was taken as a proxy for neuroinflamm… Show more
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