Are cd68 and factor viii-ra expression different in central and peripheral giant cell granuloma of jaw: an immunohistochemical comparative study

Sargolzaei, Soudabeh; Taghavi, Nasim; Poursafar, Farzaneh

doi:10.5146/tjpath.2017.01401

Cited by 5 publications

(5 citation statements)

References 20 publications

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“…On the other hand, large peripheral vessels were labeled with von Willebrand. This result is consistent with the study of Sargolzaei [24], suggesting that the involvement of von Willebrand represents an in ammatory response in PGCG and the production of pro-angiogenic factors.…”

Section: Discussionsupporting

confidence: 93%

Vascular Transmigration in Peripheral Giant Cell Lesion: a Case Study on Histogenesis

Carvalho,

Santos,

Silva

et al. 2023

Preprint

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Peripheral giant cell granulomas (PGCL) have microscopic similarities to other pathologies and their origin remains unclear. In this case, a 47-year-old woman presented with a chief complaint of a "painful bleeding lesion" in the region of the canine teeth with a recent history of tooth extraction. Intraorally, a well-circumscribed, pedunculated, purplish-red nodule was noted on the upper alveolar crest associated with an unstable denture. Periapical radiographs showed superficial bone resorption. The lesion was removed and vigorous curettage was performed. Microscopy revealed an ulcerative, non-encapsulated lesion composed of mononuclear stromal cells, prominent multinucleated giant cells (MGCs), and hemorrhage surrounded by fibrous tissue. Apoptotic MGCs were also noted. Interesting, large vessels in the periphery showed transendothelial migration of MGCs positive for matrix metallopeptidase 9 (MMP-9) and macrophage fusion marker CD44. Further studies are needed to clarify the clinical significance of vascular extension in PGCL.

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Section: Discussionsupporting

confidence: 93%

Vascular Transmigration in Peripheral Giant Cell Lesion: a Case Study on Histogenesis

Carvalho,

Santos,

Silva

et al. 2023

Preprint

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“…Twenty-one studies were mainly associated with behaviour of GCLs of jaws [ Table 3 ]. [ 5 8 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 ]…”

Section: Resultsmentioning

confidence: 99%

“…Controversy still exists regarding the nature of MSCs as it is said to have fibroblast, myofibroblast, macrophage, or endothelial origin. [ 18 50 ] Vered et al . [ 37 ] suggested that the MSCs in CGCLs undergo a dynamic process of transdifferentiation rather than existing in a constant state.…”

Section: Discussionmentioning

confidence: 99%

Unravelling the role of immunohistochemistry in giant cell lesions of jaws: A systematic review

Gupta¹,

Sharma

Hooda³

et al. 2023

J Oral Maxillofac Pathol

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Controversies exist in literature regarding nature, pathogenesis, and behaviour of giant cell lesions (GCLs) of jaws. Studies were attempted to solve these mysteries with immunohistochemical analysis, using various biological markers. Thus, the aim of this review is to appraise the role of immunohistochemistry (IHC) in evaluating the pathogenesis, cellular phenotype, nature, and behaviour of GCLs of jaws. PubMed, PubMed Central, and Clinical Key (Medline) databases were searched electronically irrespective of date of publication with assortment of several independent terms. Fifty-five articles that fulfilled the eligibility criteria were included in the review. Out of 55 included articles, 49 were associated with nature, pathogenesis, and behaviour and six articles were associated with treatment and outcome prediction. Although IHC solved some of the controversies associated with GCLs of jaws such as the osteoclastic phenotype of multinucleated giant cells, immunoexpression of proliferative markers does not distinct non-aggressive from aggressive central GCL but the nature, histogenesis, pathogenesis, and exact behaviour still remain debatable. With regard to formulation of treatment plan, immunohistochemical analysis revealed that expression of glucocorticoid and calcitonin receptors could act as a tool to decide the therapeutic strategy and aid in therapeutic adjustments according to evolution of the lesion.

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“…La relación entre la forma periférica y la central del GGC es incierta; histológicamente, ambas son muy similares y algunos autores especulan con que se diferencian solo por sus manifestaciones anatómicas. 5 En cuanto al aspecto clínico, la lesión intraósea puede ser asintomática o producir deformidad local en los huesos maxilares. 1 Se han publicado otras localizaciones, como el etmoides, el esfenoides y el temporal.…”

Section: Discussionunclassified

“…4 Histológicamente, está constituido por una proliferación de fibroblastos jóvenes, muy vascularizado y con células gigantes multinucleadas, relacionadas con espacios vasculares patológicos, mal definidos. 5 También se pueden hallar calcificaciones no específicas, osteoides y formaciones óseas y trabéculas óseas inmaduras que conforman una delgada capa periférica. 1,6,7 Las lesiones en la membrana periodontal, del mesénquima odontogénico, del saco dentario o sus células ancestrales, probablemente, sean las causas iniciadoras de esta patología.…”

Section: Introductionunclassified

Granuloma gigantocelular de mandíbula en un niño de 6 años de edad. Reporte de un caso

et al. 2019

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RESUMENEl granuloma gigantocelular representa un tumor no odontogénico que se localiza por dentro del endostio de los maxilares (central) o en el periostio (periférico). Corresponde al 3-5 % de todas las lesiones benignas de los maxilares. Es más frecuente en niños y adultos jóvenes. Se presenta como un tumor de crecimiento lento y asintomático. Preferentemente, se ubica en la mandíbula, en la región de los incisivos, caninos y premolares. Se informa sobre un paciente de 6 años de edad que, conjuntamente con la extracción del premolar temporario inferior, presentó un tejido granulomatoso de crecimiento lento en la región premolar izquierda. La toma de la biopsia fue demostrativa para granuloma gigantocelular. Se realizó el tratamiento quirúrgico, con buena evolución, sin evidencia de recidiva hasta la actualidad. Es importante el diagnóstico temprano de esta lesión por el alto poder destructivo local que presenta y la derivación oportuna para el tratamiento quirúrgico. ABSTRACTGiant cell granuloma represents a non-odontogenic tumor. It is located inside the endosteum of the jaws (central) or in the periosteum (peripheral). Although it is a benign disease process, it can also be locally destructive. This condition is a slow-growing, asymptomatic lesion that usually affects children and young adults, predominantly females in its peripheral presentation and males in its central presentation. The mandible, the region of the incisors, canines and premolars are more affected. The etiology of the giant cell granuloma still remains to be defined. It has been reported that the origin of this lesion could be triggered by trauma or inflammation and hormonal factors. A 6-year-old patient presents a slow-growing lesion in the tooth extraction's region, two months ago. The treatment is surgical. It is important to have an early diagnosis because of the high local destructive behavior and timely referral because the treatment is surgical.

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Are cd68 and factor viii-ra expression different in central and peripheral giant cell granuloma of jaw: an immunohistochemical comparative study

Cited by 5 publications

References 20 publications

Vascular Transmigration in Peripheral Giant Cell Lesion: a Case Study on Histogenesis

Vascular Transmigration in Peripheral Giant Cell Lesion: a Case Study on Histogenesis

Unravelling the role of immunohistochemistry in giant cell lesions of jaws: A systematic review

Granuloma gigantocelular de mandíbula en un niño de 6 años de edad. Reporte de un caso

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