Are candidate neurocognitive endophenotypes of OCD present in paediatric patients? A systematic review

Marzuki, Aleya A.; Souza, Ana Maria Frota Lisboa Pereira de; Sahakian, Barbara J.; Robbins, Trevor W.

doi:10.1016/j.neubiorev.2019.12.010

Cited by 30 publications

(37 citation statements)

References 182 publications

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“…We found no evidence that children with ASD or OCD showed delayed development of cognitive control over this short time. As such, these findings support the suggestion from our earlier study that any impairments in cognitive control in ASD and OCD may emerge later during development, to support findings of decreased cognitive control in adults with OCD (Chamberlain et al, 2007;Kang et al, 2012;Marzuki et al, 2020;Penadés et al, 2007;de Wit et al, 2012). This raises questions about the place of cognitive control in a mechanistic, causal cascade of repetitive behavior in these disorders.…”

Section: Discussionsupporting

confidence: 88%

“…Some studies have shown no improvement or slight worsening (Rosenthal et al, 2013;Solomon et al, 2008), whereas others have suggested developmental improvements (Christ et al, 2011;Happe et al, 2006;Luna et al, 2007). In OCD, there have been only cross-sectional studies of cognitive control to date, and those have suggested that impairments in cognitive control are not as evident in children and adolescents (Gooskens et al, 2019;Marzuki et al, 2020;Rubia et al, 2010;Wooley et al, 2008) as in adults with OCD, where longer stop-signal reaction times (SSRT) have often been reported (Chamberlain et al, 2007;Kang et al, 2012;Penadés et al, 2007;de Wit et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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The Development of Cognitive Control in Children with Autism Spectrum Disorders or Obsessive-Compulsive Disorder: A Longitudinal fMRI study

Gooskens

Bos

Naaijen

et al. 2020

Preprint

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Repetitive behavior is a core symptom of Autism Spectrum Disorder (ASD) and Obsessive-Compulsive Disorder (OCD), and has been associated with impairments in cognitive control.However, it is unclear how cognitive control and associated neural circuitry relate to the development of repetitive behavior in children with these disorders. In a multicenter, longitudinal study (TACTICS; Translational Adolescent and Childhood Therapeutic Interventions in Compulsive Syndromes), the development of cognitive control was assessed during late childhood using a longitudinal fMRI design with a modified stop-signal task in children with ASD or OCD, and typically developing (TD) children (baseline: N=122 (8-12y), follow-up: N=72 (10-14y), average interval: 1.2y). Stop-signal reaction time (SSRT) decreased over development, regardless of diagnosis. Repetitive behavior in children with ASD and OCD was not associated with performance on the stop-signal task. There were no whole-brain between-group differences in brain activity, but ROI-analyses showed increases in activity in right precentral gyrus over development for children with OCD. In sum, even though subtle differences were observed in the development of brain activity in children with OCD, the findings overall suggest that the development of cognitive control, as assessed by the stop signal task, is similar in children with and without ASD or OCD. At baseline, we were able to include data for 122 participants between 8 and 12 years (ASD = 38, OCD = 23, TD = 61) (details are described in Gooskens et al., 2019). Ninetythree participants (ASD = 34, OCD = 15, TD = 44) participated in a follow-up visit.Participants' reasons for drop-out were mainly loss of interest, or wearing dental braces which prevented them for undergoing MRI assessment. ) and were commissioned by a multicenter study (COMPULS: Naaijen et al., 2016) as part of the overarching TACTICS collaborative initiative (http://www.tactics-project.eu). Exclusion criteria for all participants were an estimated total IQ below 70 and insufficient comprehension and speaking ability of the native language of the country. For MR scanning, the presence of metal objects in the body (i.e., pacemaker, dental braces), neurological illness or other contra-indications for MRI-assessment were exclusion criteria. Participants were asked to abstain from stimulant medication 24 hours before scanning. For both diagnostic groups, a concurrent diagnosis of the other disorder was an exclusion criterion (i.e. comorbid OCD for a child with ASD, or vice versa). In TD participants or their first-degree relatives the presence of any psychiatric diagnosis was an exclusion criteria. After description of the study, parents of all participants gave written informed consent.

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Section: Discussionsupporting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

The Development of Cognitive Control in Children with Autism Spectrum Disorders or Obsessive-Compulsive Disorder: A Longitudinal fMRI study

Gooskens

Bos

Naaijen

et al. 2020

Preprint

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“…Our findings suggest that the aberrant rsFCs might occur not only in the cerebral regions but also in the cerebellocerebral region in OCD. Patients with OCD have executive dysfunctions, such as working memory, cognitive flexibility, and response inhibition (61,62). The deactivation of DMN that is associated with these cognitive performances usually occurs when an individual is required to focus attention on an external stimulus in HC (63)(64)(65).…”

Section: Discussionmentioning

confidence: 99%

Aberrant Resting-State Cerebellar-Cerebral Functional Connectivity in Unmedicated Patients With Obsessive-Compulsive Disorder

et al. 2021

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Background: Although abnormality of cerebellar-cerebral functional connectivity at rest in obsessive-compulsive disorder (OCD) has been hypothesized, only a few studies have investigated the neural mechanism. To verify the findings of previous studies, a large sample of patients with OCD was studied because OCD shows possible heterogeneity.Methods: Forty-seven medication-free patients with OCD and 62 healthy controls (HCs) underwent resting-state functional magnetic imaging scans. Seed-based connectivity was examined to investigate differences in cerebellar-cerebral functional connectivity in OCD patients compared with HCs. Correlations between functional connectivity and the severity of obsessive-compulsive symptoms were analyzed.Results: In OCD, we found significantly increased functional connectivity between the right lobule VI and the left precuneus, which is a component of the default mode network (DMN), compared to HCs. However, there was no correlation between the connectivity of the right lobule VI-left precuneus and obsessive-compulsive severity.Conclusions: These findings suggest that altered functional connectivity between the cerebellum and DMN might cause changes in intrinsic large-scale brain networks related to the traits of OCD.

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“…Независимый анализ подобных проблем демонстрирует как максимальное сходство подтипов, так и огромные расхождения между ними [28; 29]. Именно поэтому необходимы более надежные способы дифференциации различных антиобщественных типов поведения, которые будут подкрепляться несколькими независимыми критериями валидации по длиннику заболевания: семейный анамнез, наличие/отсутствие генетических маркеров, нейропсихологические особенности ребенка/подростка, выявленные при психометрическом исследовании, или динамические данные fMRI, как ответ на лечение [30][31][32]. В МКБ-10 и DSM-5 включено ODD/CD, характеризующееся повторяющимся, постоянными нарушениями поведения, носящего антисоциальный характер; а также отдельными формами отклоняющегося поведения, не классифицируемого в других рубриках.…”

Section: вопросы классификации и критерии диагностики Odd/cdunclassified

Oppositional Defiant Disorder in Childhood and Adolescence

Владимировна

Викторович

Валерьевна

et al. 2020

ISci

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Oppositional defiant disorder (ODD) and conduct disorder (CD), which usually develop at the age below 18, are considered as a sustainable antisocial and aggressive types of behavior, stepping beyond the borders of socially accepted standards. Within the recent decades, significant success has been achieved in the diagnosis and long-term predictive assessment of different types of behavioral aberrations, occurring during the childhood and adolescence. Early development of behavioral disorders forms unfavorable predictions and correlates with biological and social risk factors, such as attention deficit, impulse control disorder and unfavorable social environment. Most of the clinical observations confirm the effectiveness of different psychotherapeutic programs in the therapy of ODD/CD. The drug treatment is proposed to be used only in the severe cases, or in the cases when psychotherapeutic methods are not effective.

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Are candidate neurocognitive endophenotypes of OCD present in paediatric patients? A systematic review

Cited by 30 publications

References 182 publications

The Development of Cognitive Control in Children with Autism Spectrum Disorders or Obsessive-Compulsive Disorder: A Longitudinal fMRI study

The Development of Cognitive Control in Children with Autism Spectrum Disorders or Obsessive-Compulsive Disorder: A Longitudinal fMRI study

Aberrant Resting-State Cerebellar-Cerebral Functional Connectivity in Unmedicated Patients With Obsessive-Compulsive Disorder

Oppositional Defiant Disorder in Childhood and Adolescence

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