Are Brazilian bamboo species helpful for cognition and memory?

Gagliano, Janayne; Altenhofen, Stefani; Nabinger, Débora Dreher; Gusso, Darlan; Kuhl-Silva, Julia Maria; Anselmo-Moreira, Fernanda; Yamaguchi, Lydia F.; Kato, Massuo Jorge; Bonan, Carla Denise; Furlan, Cláudia Maria

doi:10.1016/j.phyplu.2021.100183

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…The first band (I) is associated with ring A, with UV absorption occurring between λmax ≈ 300 and 500 nm, while the second band (II) is associated with ring B, which absorbs at between λmax ≈ 240 and 280 nm. Notably, we found that many of the flavonoids corresponded to glycosylated flavone scaffolds, in accordance with reports in the literature, highlighting a range of flavones with absorptions between λmax ≈ 275 and 335 nm [18].…”

Section: Chemical Characterization Of Extractsupporting

confidence: 91%

Uncovering Metabolic Alterations in HCT-116 Colon Cancer Cells upon Exposure to Bamboo Leaf Extract Obtained from Guadua incana Londoño

Chitiva,

Santamaría-Torres,

Rezende-Teixeira

et al. 2024

Molecules

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Metabolic alterations are increasingly recognized as important aspects of colorectal cancer (CRC), offering potential avenues for identifying therapeutic targets. Previous studies have demonstrated the cytotoxic potential of bamboo leaf extract obtained from Guadua incana (BLEGI) against HCT-116 colon cancer cells. However, the altered metabolic pathways in these tumor cells remain unknown. Therefore, this study aimed to employ an untargeted metabolomic approach to reveal the metabolic alterations of the endometabolome and exometabolome of HCT-116 cells upon exposure to BLEGI treatment. First, a chemical characterization of the BLEGI was conducted through liquid chromatography coupled with mass spectrometry (LC-MS). Next, we assessed cell viability via MTT and morphological analysis using an immunofluorescence assay against colon cancer cells, and anti-inflammatory activity using an LPS-stimulated macrophage model. Subsequently, we employed LC-MS and proton nuclear magnetic resonance (1H-NMR) to investigate intra- and extracellular changes. Chemical characterization primarily revealed the presence of compounds with a flavone glycoside scaffold. Immunofluorescence analysis showed condensed chromatin and subsequent formation of apoptotic bodies, suggesting cell death by apoptosis. The results of the metabolomic analysis showed 98 differential metabolites, involved in glutathione, tricarboxylic acid cycle, and lipoic acid metabolism, among others. Additionally, BLEGI demonstrated significant nitric oxide (NO) inhibitory capacity in macrophage cells. This study enhances our understanding of BLEGI’s possible mechanism of action and provides fresh insights into therapeutic targets for treating this disease.

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Section: Chemical Characterization Of Extractsupporting

confidence: 91%

Uncovering Metabolic Alterations in HCT-116 Colon Cancer Cells upon Exposure to Bamboo Leaf Extract Obtained from Guadua incana Londoño

Chitiva,

Santamaría-Torres,

Rezende-Teixeira

et al. 2024

Molecules

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Phenolic diversity and antioxidant potential of different varieties of bamboo leaves using LC-ESI-QTOF-MS/MS and LC-ESI-QqQ-MS/MS

Andressa Almeida Farias,

Rodrigues dos Reis,

Rodrigues de Morais

et al. 2024

Food Research International

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Metabolomic Profiling of Guadua Species and Its Correlation with Antioxidant and Cytotoxic Activities

Chitiva,

Rezende-Teixeira,

Leão

et al. 2024

ACS Omega

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Bamboo plants are widely used in Asian traditional medicine for various health issues and exhibit therapeutic potential. Guadua species are renowned bamboos for their high phenolic compound content, including flavonoids and hydroxycinnamic acid derivatives, and possess noteworthy biological properties. Despite this, there is a notable scarcity of research on the chemical and biological aspects of Latin American bamboo leaf extracts (BLEs), especially concerning the Guadua genus. This study aimed to employ a metabolomics approach to integrate the phytochemical and activity profiles of BLEs to identify potential bioactive markers. We determined the metabolic fingerprints of 30 BLEs through HPTLC, HPLC-DAD, UHPLC-QTOF-MS, and 1 H-NMR analyses and screened for antioxidant and cytotoxic activities using ABTS, DPPH, and MTT methods. Ultimately, correlation analyses were performed by using chemometric methods and molecular networking. Our findings present a comprehensive chemical characterization, encompassing 40 flavonoids and 9 cinnamic acid derivatives. Notably, most of these compounds have been reported for the first time within the genus, signifying novel discoveries. Additionally, certain compounds identified in other species of the subfamily Bambusoideae provide valuable comparative insights. These compounds demonstrated a significant correlation with antioxidant potential, with values exceeding 100 and 30 μmol of TE/g of extract for ABTS and DPPH, respectively, in the samples. Extracts from G. incana and G. angustifolia exhibited potent cytotoxic effects with IC 50 values of 1.23 and 4.73 μg/mL against HCT-116 colon cancer cells, respectively. Notably, glycosylated flavones showed a strong correlation with cytotoxicity. These new findings significantly contribute to our understanding of the chemical composition and biological properties of these often overlooked bamboo species, providing them with important added value and alternative use.

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Are Brazilian bamboo species helpful for cognition and memory?

Cited by 3 publications

References 26 publications

Uncovering Metabolic Alterations in HCT-116 Colon Cancer Cells upon Exposure to Bamboo Leaf Extract Obtained from Guadua incana Londoño

Uncovering Metabolic Alterations in HCT-116 Colon Cancer Cells upon Exposure to Bamboo Leaf Extract Obtained from Guadua incana Londoño

Phenolic diversity and antioxidant potential of different varieties of bamboo leaves using LC-ESI-QTOF-MS/MS and LC-ESI-QqQ-MS/MS

Metabolomic Profiling of Guadua Species and Its Correlation with Antioxidant and Cytotoxic Activities

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