Are basal D-serine plasma levels a predictive biomarker for the rapid antidepressant effects of ketamineand ketamine metabolites?

Wainer, Irving W.

doi:10.1007/s00213-014-3736-6

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Journal Of Clinical and Experimental Pharmacology1

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2015

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“…Indeed, a recent study by Goldberg, et al suggests that basal D-serine plasma concentration may be a biomarker to determine which patients are likely to benefit from ketamine infusions in the treatment of MDD [19]. Using the Montgomery Asberg Depression Rating Scale with greater than 50% decrease as a positive response, this study noted that decreased baseline levels of D-Ser has a direct correlation with response to treatment [11,19,20].…”

Section: Journal Of Clinical and Experimental Pharmacologymentioning

confidence: 88%

Ketamine: An Update for Its Use in Complex Regional Pain Syndrome and Major Depressive Disorder

Bentley¹

2015

Clin Exp Pharmacol

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In recent years, there has been significant research in regard to the efficacy of ketamine in regards to treating Complex Regional Pain Syndrome (CRPS) and Major Depressive Disorder (MDD). Many patients have had substantial symptomatic relief; however, not all patients have had positive results. This has prompted current research with evidence to suggest certain biomarkers exist that would infer which patients will/will not respond to ketamine treatment. Current biomarkers of interest include D-Serine (D-Ser) and magnesium, which will be discussed. Whether or not D-Ser and/or magnesium levels should be checked and possibly dictate therapy is an area of future research. It is also possible that downstream metabolites of ketamine are the key to successful therapy.

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Section: Journal Of Clinical and Experimental Pharmacologymentioning

confidence: 88%

Ketamine: An Update for Its Use in Complex Regional Pain Syndrome and Major Depressive Disorder

Bentley¹

2015

Clin Exp Pharmacol

View full text Add to dashboard Cite

show abstract

Are basal D-serine plasma levels a predictive biomarker for the rapid antidepressant effects of ketamineand ketamine metabolites?

Cited by 1 publication

References 6 publications

Ketamine: An Update for Its Use in Complex Regional Pain Syndrome and Major Depressive Disorder

Ketamine: An Update for Its Use in Complex Regional Pain Syndrome and Major Depressive Disorder

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