Are Bacteria Infectious Pathogens in Hidradenitis Suppurativa? Debate at the Symposium for Hidradenitis Suppurativa Advances Meeting, November 2017

Naik, Haley B.; Nassif, Aude; Ramesh, Mayur; Schultz, Gregory S.; Piguet, Vincent; Alavi, Afsáneh; Lowes, Michelle A.

doi:10.1016/j.jid.2018.09.036

Cited by 27 publications

(21 citation statements)

References 24 publications

(22 reference statements)

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“…HS is not contagious and there are usually no typical complications of infection, such as sepsis or cellulitis. Commensal microbiota in altered abundances may result in dysbiosis . In a study analysing lesional, non‐lesional, and healthy skin control biopsies, sequencing data identified different proportions of commensal bacteria in each specimen .…”

Section: Scientific Session 3: Pathophysiology Of Hidradenitis Suppurmentioning

confidence: 98%

“…Commensal microbiota in altered abundances may result in dysbiosis. [26] In a study analysing lesional, non-lesional, and healthy skin control biopsies, sequencing data identified different proportions of commensal bacteria in each specimen. [27] These data suggest bacteria may be secondary drivers in HS, with some evidence of microbiome alterations in HS lesional skin compared to healthy volunteers.…”

Section: Update On Bacteriology and Microbiome In Hidradenitis Suppmentioning

confidence: 99%

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Proceeding report of the third symposium on Hidradenitis Suppurativa advances (SHSA) 2018

Rios

Sarfo

Ghias

et al. 2019

Experimental Dermatology

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The 3rd Annual Symposium on Hidradenitis Suppurativa Advances (SHSA) took place on 12‐14 October 2018 at the Women's College Hospital in Toronto, Ontario, Canada. This symposium was a joint meeting of the Hidradenitis Suppurativa Foundation (HSF) founded in the USA and the Canadian Hidradenitis Suppurativa Foundation (CHSF). This cross‐disciplinary meeting with experts from around the world was an opportunity to discuss the most recent advances in the study of hidradenitis suppurativa pathogenesis, epidemiology, classification, scoring systems, radiologic diagnosis, treatment approaches and psychologic assessment. Two special sessions this year were HS as a systemic disease and HS management guidelines. There were focused workshops on wound healing and ultrasound. There were two sessions primarily for patients and their families in the HS School programme: One workshop focused on mindfulness, and the second involved discussion among clinicians and patients about various disease aspects and the latest management. To facilitate networking between clinical and research experts and those early in their career, a mentoring breakfast was held.

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Section: Scientific Session 3: Pathophysiology Of Hidradenitis Suppurmentioning

confidence: 98%

Section: Update On Bacteriology and Microbiome In Hidradenitis Suppmentioning

confidence: 99%

Proceeding report of the third symposium on Hidradenitis Suppurativa advances (SHSA) 2018

Rios

Sarfo

Ghias

et al. 2019

Experimental Dermatology

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“…As a result, primary infection is viewed as an unlikely cause of HS (38,39). In addition, the lack of strong therapeutic effect of antibiotic treatment further argues against a primary infectious cause (40). However, it is still possible that microbial "dysbiosis" and an altered skin microbiome are important factors contributing to HS pathogenesis.…”

Section: Bacteriamentioning

confidence: 99%

Hidradenitis Suppurativa: Current Understanding of Pathogenic Mechanisms and Suggestion for Treatment Algorithm

2020

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Hidradenitis suppurativa is one of the most distressing dermatological conditions and has a significant negative impact on patients' quality of life. However, the exact pathogenic mechanisms remain incompletely understood and-therefore-efficient therapies are still lacking. The current manuscript focuses on new findings on its pathogenic mechanisms and aims to provide practical therapy recommendations.

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“…Epidemiological studies suggest the influence of many genetic and environmental factors. In addition to family cases due to mutations in genes encoding essential components of the γ-secretase multiprotein complex (PSEN1, PSENEN, and NCSTN genes) [ 12 , 13 , 14 , 15 ], several other factors including psychological influences, metabolism, smoking habits, bacterial infections, and associations with other diseases (mainly inflammatory disorders) have been related to a higher incidence of HS [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 16 , 29 ]. Recently, our group reported on the role of several adipokines (adiponectin, leptin, resistin, and visfatin) in patients with HS and investigated the possible associations with insulin resistance, HS risk, and disease severity [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…The role of bacteria in the pathogenesis of HS is controversial. It has been suggested that these infectious agents may play a role in disease progression rather that in the pathogenesis itself [ 2 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Association of Human Leukocyte Antigens Class II Variants with Susceptibility to Hidradenitis Suppurativa in a Caucasian Spanish Population

Ocejo-Vinyals

Fernández-Viña

Cantos-Mansilla

et al. 2020

JCM

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Hidradenitis suppurativa (HS) is a chronic inflammatory cutaneous disease of the hair follicle typically presenting recurrent, painful, and inflamed lesions on the inverse areas of the body. Although its pathogenesis remains unknown, the immune system appears to play a potential role. To date, two previous studies have not found any association between the Human Leukocyte Antigen system (HLA) and HS. In this study we analyzed the HLA-A, -B, -C; and DRB1, -DQA1, and –DQB1 allele distribution in 106 HS patients and 262 healthy controls from a Caucasian population in Cantabria (northern Spain). HLA-A*29 and B*50 were significantly more common in HS patients and A*30 and B*37 in controls, but these associations disappeared after statistical correction. DRB1*07, DQA1*02, and DQB1*02 were significantly more common in controls (p 0.026, p 0.0012, and p 0.0005, respectively) and the HLA allele DQB1*03:01 was significantly more common in HS patients (p 0.00007) after the Bonferroni correction. The DRB1*07~DQA1*02~DQB1*02 haplotype was significantly more common in controls (p < 0.0005). This is the first study showing an association between HLA-class II and HS. Our results suggest that HLA-II alleles (DRB1*07, DQA1*02, DQB1*02, and DQB1*03:01) and the DRB1*07~DQA1*02~DQB1*02 haplotype could influence resistance or susceptibility to HS.

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Are Bacteria Infectious Pathogens in Hidradenitis Suppurativa? Debate at the Symposium for Hidradenitis Suppurativa Advances Meeting, November 2017

Cited by 27 publications

References 24 publications

Proceeding report of the third symposium on Hidradenitis Suppurativa advances (SHSA) 2018

Proceeding report of the third symposium on Hidradenitis Suppurativa advances (SHSA) 2018

Hidradenitis Suppurativa: Current Understanding of Pathogenic Mechanisms and Suggestion for Treatment Algorithm

Association of Human Leukocyte Antigens Class II Variants with Susceptibility to Hidradenitis Suppurativa in a Caucasian Spanish Population

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