Are Amniotic Fluid Alpha-Fetoprotein Levels Influenced by the Gender in Twin Pairs?

Sharony, Reuven; Drugan, Arie; Amiel, Aliza; Grinshpun‐Cohen, Julia; Markov, Shlomo; Fejgin, Moshe D.

doi:10.1159/000071015

Cited by 3 publications

(1 citation statement)

References 10 publications

(8 reference statements)

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“…They concluded that in singleton or twin pregnancies, the AFP concentration in amniotic fluid is not affected by fetal gender [25] . A similar conclusion was reached by Sharony et al [26] . They observed that in gender discordant twins, the difference in the AFAFP concentrations is not statistically significant.…”

Section: Discussionsupporting

confidence: 87%

Amniocentesis for Twin Pregnancies: Is Alpha-Fetoprotein Useful in Confirming that the Two Sacs Were Sampled?

Delisle

Wilson²

2007

Fetal Diagn Ther

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Objective: To assess if amniotic fluid alpha-fetoprotein (AFAFP) could be useful to determine if both sacs are sampled during an amniocentesis for twin pregnancies. Method: We reviewed all amniocenteses performed on twin pregnancies over a 5-year period. Inclusion criteria were restricted to pregnancies where both karyotypes and AFAFP were available on each fetus. Pregnancies complicated by fetal anomalies were excluded. The following information was obtained: maternal age, gestational age at the procedure, karyotypes, AFAFP values, pregnancy and neonatal outcome. Placental pathology reports were used to confirm chorionicity. Analysis was performed to evaluate the impact of the fetal gender and chorionicity on the AFAFP values. Results: 260 pregnancies were reviewed. Mean maternal age was 36.9 years (33.6, 40.1). Gestational age at the time of the procedure was 16.2 weeks (14.5, 17.9). Complications included 1.8% of misdiagnosis (discrepancy between karyotype and gender). The difference of AFAFP values between the two fetuses was statistically larger in dichorionic pregnancies than in monochorionic gestations. Fetal gender had no influence on the AFAFP. Conclusion: Amniocentesis in twin pregnancies is associated with a 1.8% risk of misdiagnosis. AFAFP can help to assess the chorionicity of a twin pregnancy. When the difference between the two values is <0.2 MoM and the chorionicity was thought to be dichorionic and the two karyotypes are similar, then failure to sample both sacs should be suspected.

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Section: Discussionsupporting

confidence: 87%

Amniocentesis for Twin Pregnancies: Is Alpha-Fetoprotein Useful in Confirming that the Two Sacs Were Sampled?

Delisle

Wilson²

2007

Fetal Diagn Ther

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Current awareness in prenatal diagnosis

2003

Prenatal Diagnosis

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of prenatal diagnosis. Each bibliography is divided into 17 sections: 1 Books, Reviews & Symposia; 2 General Interest; 3 Normal Fetal Development; 4 Gametogenesis and Pre‐implantation Diagnosis; 5 First Trimester Diagnosis; 6 Second Trimester Diagnosis; 7 Fetal Diagnosis by Ultrasound and Other Imaging; 8 Maternal Screening; 9 Screening for Carriers of Genetic Abnormality; 10 Technological Developments; 11 Confined Placental Mosaicism and Uniparental Disomy; 12 Molecular Cytogenetics; 13 Fetal Cells in Maternal Circulation; 14 Fetal Therapy; 15 Psychosocial Aspects; 16 Epidemiology and Environmental Factors; 17 Developmental Pathology. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted

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Alpha-fetoprotein and its value for predicting pregnancy outcomes � a re-evaluation

Darouich

Liehr

Weise

et al. 2015

JPM

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Introduction: Alpha-fetoprotein (AFP) concentrations can be determined framing others from invasively acquired amnion fluid (AF-AFP). While the biological role of AFP remains unclear it is well known that AFP-levels can be altered in connection with specific clinical and/or genetic alterations of the fetus. Materials and Method: here a retrospective study based on 3,119 singleton and 56 twin pregnancies is presented. The standard levels of amnion fluid derived alpha-fetoprotein level (AF-AFP) between 12th and 36th weeks of gestation were determined. Additionally, acetylcholinesterase (AChE) test results for 63 cases, ultrasonography results for 32 cases and abnormal karyotypic findings for 100 cases were available for selected cases. Results and Discussion: according to the present data the AF-AFP test is reliable and provides ex-

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Are Amniotic Fluid Alpha-Fetoprotein Levels Influenced by the Gender in Twin Pairs?

Cited by 3 publications

References 10 publications

Amniocentesis for Twin Pregnancies: Is Alpha-Fetoprotein Useful in Confirming that the Two Sacs Were Sampled?

Amniocentesis for Twin Pregnancies: Is Alpha-Fetoprotein Useful in Confirming that the Two Sacs Were Sampled?

Current awareness in prenatal diagnosis

Alpha-fetoprotein and its value for predicting pregnancy outcomes � a re-evaluation

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