Are Ambient Ultrafine, Accumulation Mode, and Fine Particles Associated with Adverse Cardiac Responses in Patients Undergoing Cardiac Rehabilitation?

Rich, David Q.; Zaręba, Wojciech; Beckett, William S.; Hopke, Philip K.; Oakes, David; Frampton, Mark W.; Bisognano, John D.; Chalupa, David; Bausch, Jan; O’Shea, Karen M.; Wang, Yungang; Utell, Mark J.

doi:10.1289/ehp.1104262

Cited by 106 publications

(110 citation statements)

References 34 publications

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“…Links between daily changes in ultrafine particles and markers of altered cardiac function, inflammation and coagulation were suggested by several, but not all, studies (see reviewed studies within Rückerl et al (2011) andWeichenthal (2012)) and were further supported by recently published studies (Rich et al, 2012b).…”

Section: Epidemiological Studiesmentioning

confidence: 79%

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Broome¹,

Johnston

Horsley

et al. 2016

Medical Journal of Australia

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This document presents answers to 24 questions relevant to reviewing European policies on air pollution and to addressing health aspects of these policies. The answers were developed by a large group of scientists engaged in the WHO project "Review of evidence on health aspects of air pollution -REVIHAAP". The experts reviewed and discussed the newly accumulated scientific evidence on the adverse effects on health of air pollution, formulating science-based answers to the 24 questions. Extensive rationales for the answers, including the list of key references, are provided. The review concludes that a considerable amount of new scientific information on the adverse effects on health of particulate matter, ozone and nitrogen dioxide, observed at levels commonly present in Europe, has been published in recent years. This new evidence supports the scientific conclusions of the WHO air quality guidelines, last updated in 2005, and indicates that the effects in some cases occur at air pollution concentrations lower than those serving to establish these guidelines. It also provides scientific arguments for taking decisive actions to improve air quality and reduce the burden of disease associated with air pollution in Europe.This publication arises from the project REVIHAAP and has been co-funded by the European Union. Keywords AIR POLLUTANTS AIR POLLUTION -ADVERSE EFFECTS ENVIRONMENT AND PUBLIC HEALTH EVIDENCE BASED PRACTICE GUIDELINES HEALTH POLICYAddress requests about publications of the WHO Regional Office for Europe to: Publications WHO Regional Office for Europe Scherfigsvej 8 DK-2100 Copenhagen Ø, Denmark Alternatively, complete an online request form for documentation, health information, or for permission to quote or translate, on the Regional Office web site (http://www.euro.who.int/pubrequest). © World Health Organization 2013All rights reserved. The Regional Office for Europe of the World Health Organization welcomes requests for permission to reproduce or translate its publications, in part or in full.The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the World Health Organization concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. Dotted lines on maps represent approximate borderlines for which there may not yet be full agreement.The mention of specific companies or of certain manufacturers products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters.All reasonable precautions have been taken by the World Health Organization to verify the information contained in this publication. However, the published material is being distributed without warranty of any kind, either express or implied. ...

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Section: Epidemiological Studiesmentioning

confidence: 79%

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Broome¹,

Johnston

Horsley

et al. 2016

Medical Journal of Australia

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“…Further research is required in order to determine the dose-response relationship, the dynamics of the neurovegetative disturbances and to assess the long-term effects of exposure to dusts on the cardivascular system. other diseases, some of them undergoing medical treatment [55][56][57]. The analysis of the frequency-domain parameters has shown that power in the range of high frequency (HF) in the exposed group was significantly higher than in the control group.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular changes in workers exposed to fine particulate dust

Bortkiewicz¹,

Gadzicka²,

Stroszejn-Mrowca³

et al. 2014

International Journal of Occupational Medicine and Environmental Health

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Objectives: Epidemiological studies provide evidence that airborne particulate matter may contribute to the increased incidence and mortality rates due to pulmonary and cardiovascular diseases. Only some of them address the problem of occupational exposure to particulate air pollution. The aim of our study was to assess cardiovascular reaction and autonomic regulation in workers exposed to fine particles. Materials and Methods: All workers had medical examination, resting ECG with heart rate variability analysis (HRV), 24-h ECG, and ambulatory blood pressure monitoring (ABPM) performed. The subjects were 20 male workers (mean age: 32.14.0 year) of a ceramic ware factory exposed to the dust and 20 workers who were not exposed (mean age: 39.4±7.8 year). The period of employment under exposure amounted to 5.6±2.1 year. Dust exposure was measured using individual dosimeters. Results: The geometric mean total dust concentration was 44±1.5 mg/m 3 and the FPD (fine particulate dust) concentration amounted to 11.5±1.6 mg/m 3 . No abnormalities were noted in the resting ECG in both groups, in 24-h ECG 2 subjects, both from exposed and control groups, had ventricular heart rhythm and repolarization disturbances. Blood pressure in ABPM, both systolic as well as diastolic, was normal and did not differ between the groups. Resting heart rate in the exposed group was significantly lower (p = 0.038) than in the control group. In the exposed group STD R-R from short-term records was significantly higher (p = 0.01). Fast Fourier Transform (FFT) analysis showed that the low frequency power spectrum (LF) did not differ in the exposed and the control group, while high frequency (HF) was significantly higher in the exposed group. LF/HF ratio was significantly lower in the exposed in comparison with the control group. Conclusions: Although we did not reveal significant abnormalities in ECG as well as in ABPM in the exposed group, it seems that neurovegetative disturbances (parasympathetic predominance) may serve as an early indicator of fine particulate dust effect on cardiovascular system. Key words:Ceramic industry, Heart rate variability, Air pollution, Respirable dust, Blood pressure monitoring, ABPM This study was supported by Nofer Institute of Occupational Medicine: IMP 4.10./2004 "Occupational exposure to ultrafine particles (PM < 10 μm)" as a risk factor for cardiovascular diseases (manager of project: Irena Szadkowska-Stańczyk, prof.) and IMP 20.5 "Return to work after first acute coronary syndrome: The analysis of factors that affect the continuation of occupational activity" (manager of project: Elżbieta Gadzicka, MD, PhD).

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“…In an epidemiological report, UFP has been associated with adverse changes in HRV during an exercise session among cardiac rehabilitation patients. 66 Reducing personal air pollution exposure using a facemask increased HRV among both healthy volunteers 67 and CAD patients 68 after moderate exercise in highly polluted Beijing.…”

Section: Heart Rate Variabilitymentioning

confidence: 99%

Air Pollution and Exercise

Giorgini

Rubenfire

Bard

et al. 2016

Journal of Cardiopulmonary Rehabilitation and Prevention

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Although regular aerobic exercise improves overall health, increased physical activity can lead to heightened exposures to a variety of air pollutants. As such, the cardiovascular health benefits of exercise may be abrogated to some degree by the harmful actions of inhaled pollutants. This review aims to provide an up-to-date summary for health professionals of the cardiovascular responses as well as the risks of exercising in air pollution. Aerobic exercise augments the overall inhaled air pollution dose, potentiates the diffusion of pollutants into circulating blood, and augments oxidative stress and inflammation. The inhalation of particulate matter during exercise can raise blood pressure, impair vascular function, and unfavorably affect autonomic balance. Several studies suggest that air pollutants can increase ischemic symptoms and signs during exercise and can even be capable of impairing exercise performance in some scenarios. The overall evidence supports that the risk-to-benefit ratio generally favors that health care providers continue to strongly encourage their patients to perform regular aerobic exercise. Nevertheless, a greater effort should be made to educate patients about the risks of air pollutant exposures during exercise, particularly those at heightened cardiovascular risk. Although no strategy has been directly tested to reduce morbidity and mortality rate, several prudent actions can be taken to lessen the degree of exposures during exercise which may thereby help mitigate the adverse effects of air pollutants on exercise performance and cardiovascular risk.

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Are Ambient Ultrafine, Accumulation Mode, and Fine Particles Associated with Adverse Cardiac Responses in Patients Undergoing Cardiac Rehabilitation?

Cited by 106 publications

References 34 publications

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

A rapid assessment of the impact of hazard reduction burning around Sydney, May 2016

Cardiovascular changes in workers exposed to fine particulate dust

Air Pollution and Exercise

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