Are agricultural and natural sources of bio-products important for modern regenerative medicine? A review

Nowacki, Maciej; Nowacka, Krystyna; Kloskowski, Tomasz; Pokrywczyńska, Marta; Tyloch, Dominik; Rasmus, Marta; Warda, Karolina

doi:10.5604/12321966.1235171

Cited by 5 publications

(3 citation statements)

References 43 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Whereas, calcium sodium alginate fibers are utilized widely in clinical practice as hemostatic wound dressings (Thomas, 2000). The modifiable properties of alginate undoubtedly augment its applications for clinical use and further examples of clinical trials using alginate include the treatment of pressure sores, post-operative intrauterine adhesions, reflux suppression, weight loss, skin grafts, burns, and surgical wounds (Nowacki et al, 2017).…”

Section: Biocompatibilitymentioning

confidence: 99%

Plant-Derived Biomaterials: A Review of 3D Bioprinting and Biomedical Applications

et al. 2019

View full text Add to dashboard Cite

The pursuit of appropriate, biocompatible materials is one of the primary challenges in translational bioprinting. The requirement to refine a biomaterial into a bioink places additional demands on the criteria for candidate biomaterials. The material must enable extrusion as a liquid bioink and yet be capable of maintaining its shape in the post-printing phase to yield viable tissues, organs and biological materials. Plant-derived biomaterials show great promise in harnessing both the natural strength of plant microarchitecture combined with their natural biological roles as supporters of cell growth. The aim of this review article is to outline the most widely used biomaterials derived from land plants and marine algae: nanocellulose, pectin, starch, alginate, agarose, fucoidan, and carrageenan, with an in-depth focus on nanocellulose and alginate. The properties that render these materials as promising bioinks for three dimensional bioprinting is herein discussed alongside their potential in 3D bioprinting for tissue engineering, drug delivery, wound healing, and implantable medical devices.

show abstract

Section: Biocompatibilitymentioning

confidence: 99%

Plant-Derived Biomaterials: A Review of 3D Bioprinting and Biomedical Applications

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Notably, medicine, agriculture, and animal husbandry are actually developing conjointly. Continuing advances in agriculture and natural biomaterials have a crucial directing effect on the trend of tissue engineering and regenerative medicine [ 79 ]. Thus, the biotechnology of modern cellular agriculture has high research value far beyond itself.…”

Section: Extensive Application Prospects and Current Shortcomings Of ...mentioning

confidence: 99%

Bioprocessing by Decellularized Scaffold Biomaterials in Cultured Meat: A Review

Ying

Shi

et al. 2022

Bioengineering

View full text Add to dashboard Cite

As novel carrier biomaterials, decellularized scaffolds have promising potential in the development of cellular agriculture and edible cell-cultured meat applications. Decellularized scaffold biomaterials have characteristics of high biocompatibility, bio-degradation, biological safety and various bioactivities, which could potentially compensate for the shortcomings of synthetic bio-scaffold materials. They can provide suitable microstructure and mechanical support for cell adhesion, differentiation and proliferation. To our best knowledge, the preparation and application of plant and animal decellularized scaffolds have not been summarized. Herein, a comprehensive presentation of the principles, preparation methods and application progress of animal-derived and plant-derived decellularized scaffolds has been reported in detail. Additionally, their application in the culture of skeletal muscle, fat and connective tissue, which constitute the main components of edible cultured meat, have also been generally discussed. We also illustrate the potential applications and prospects of decellularized scaffold materials in future foods. This review of cultured meat and decellularized scaffold biomaterials provides new insight and great potential research prospects in food application and cellular agriculture.

show abstract

“…Существуют различные техники децеллюляризации, получившие широкое признание в регенеративной медицине [2]. С помощью этих методов можно создавать тканеспецифические каркасы, наиболее точно имитирующие физические и химические сигналы, необходимые для прикрепления, пролиферации, миграции, дифференциации и восстановления функций клеток [3].…”

Section: Introductionunclassified

Morphological analysis of a local tissue response to subcutaneously implanted acellular dermal matrix fragments

et al. 2022

View full text Add to dashboard Cite

Acellular dermal matrices (ADMs) are gaining popularity as surgical materials for operations on the pelvic organs, as well as in burn therapy and plastic surgery. Evaluation of the biocompatibility of surgical materials is an important and necessary step in the development of new ADMs.The aim of the study was to compare the results of subcutaneous implantation of ADM and native porcine skin in rats.Materials and methods. To obtain ADMs, detergent – enzymatic decellularization was used. On days 7, 14, 21, and 60 after the implantation of ADMs (the experimental group) and native porcine skin (the control group), the animals were removed from the experiment. The histologic sections were stained with hematoxylin – eosin and Masson’s trichrome stain, then an immunohistochemical reaction with antibodies to CD3 and CD68 was performed. Computer morphometry was carried out using the ImageJ software.Results. On day 7 after the implantation, moderate sterile inflammation in the experimental group and pronounced sterile inflammation with eosinophil infiltration in the control group were observed. On day 14 of the experiment, the samples from the experimental group were characterized by a relatively low content of macrophages and T-lymphocytes with insignificant edema and no signs of ADM biodegradation. The control group showed pronounced inflammation, a large number of infiltrating macrophages and T lymphocytes, as well as fragmentation of collagen fibers. On day 21 of the experiment, a thin capsule was formed around ADM, there was a small number of infiltrating T lymphocytes and macrophages, the collagen fibers of the implant were intact. In the samples of the control group, there was pronounced inflammation with the presence of a significant number of lymphocytes and macrophages, as well as fragmentation and vascularization of the implant. On day 60 of the experiment, no inflammatory response was observed around ADM, biodegradation was minimal, and a dense fibrous capsule was formed around the fragment of the native porcine skin.Conclusion. The experimental ADM has low immunogenicity and a low degree of biodegradation, which makes it possible to use it for further research to create efficient surgical material that is safe for use in clinical practice.

show abstract

Are agricultural and natural sources of bio-products important for modern regenerative medicine? A review

Cited by 5 publications

References 43 publications

Plant-Derived Biomaterials: A Review of 3D Bioprinting and Biomedical Applications

Plant-Derived Biomaterials: A Review of 3D Bioprinting and Biomedical Applications

Bioprocessing by Decellularized Scaffold Biomaterials in Cultured Meat: A Review

Morphological analysis of a local tissue response to subcutaneously implanted acellular dermal matrix fragments

Contact Info

Product

Resources

About