Are acylphloroglucinols lead structures for the treatment of degenerative diseases?

Verotta, Luisellá

doi:10.1023/a:1026069624278

Cited by 115 publications

(73 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…St. John's wort (Hypericum perforatum L.) is the most important medicinal species of the genus and its main uses in medicine includes treatment of mild and moderate depression, skin wounds and burns (Barnes et al 2001). The plant contains a vast array of secondary metabolites, among which naphthodianthrones (hypericin and pseudohypericin), acylphloroglucinols (hyperforin and adhyperforin) and essential oil can be mentioned (Morshedloo et al 2012;Radusiene et al 2005;Verotta 2002; Greeson et al 2001). Antiviral, antiretroviral and antitumor activities (Orčić et al 2011;Percifield et al 2007;Glisic et al 2006;Agostinis et al 2002;Meruelo et al 1988) of extracts from this plant make it promising for treatment of HIV and cancer.…”

Section: Introductionmentioning

confidence: 99%

Genetic relationships of Iranian Hypericum perforatum L. wild populations as evaluated by ISSR markers

et al. 2014

View full text Add to dashboard Cite

St. John's wort (Hypericum perforatum L.), as the most important medicinal species of the genus Hypericum, is medicinally used for many purposes such as treatment of mild and moderate depression. Considering importance of knowledge on genetic structure of wild relatives of crop plants, the present study was aimed to assess genetic variability among ten wild populations of H. perforatum growing in different climatic regions of Iran via ISSR markers. In general 15 selected primers generated 191 polymorphic fragments with an average of 12 in each primer. According to the UPGMA constructed dendrogram and PCoA, studied populations were classified into four main groups which was, to the some extent, in accordance with their geographical origins. Genetic distances of these populations ranged from 0.109 (Nor and Nowshahr) to 0.345 (Ardebil and Galogah). Also, Nei gene diversity (H e ) values were calculated to be from 0.066 to 0.216 and Shannon's information indices (I) varied from 0.321 to 0.097. Nei's genetic differentiation index (G st ) was high (0.573) indicating the high levels of genetic variation among the studied populations. Finally, the gene flow (N m ) value was found to be 0.372. Obtained information is useful for use of Iranian H. perforatum germplasm for breeding programs and for development of effective conservation strategies.

show abstract

Section: Introductionmentioning

confidence: 99%

Genetic relationships of Iranian Hypericum perforatum L. wild populations as evaluated by ISSR markers

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Chemical instability of hyperforin and adhyperforin, major phloroglucinol constituents of Hypericum perforatum flowers and leaves, leads to changes in the composition of extracts and, until recently, prevented its pharmacological evaluation [26]. A number of oxidized derivatives of hyperforin and adhyperforin were identified by HPLC-MS analyses as their degradation products (furohyperforin isomers, furohyperforin hydroperoxide, furoadhyperforin isomers, furoadhyperforin hydroperoxide) [27].…”

mentioning

confidence: 99%

Fragmentation pathways of polycyclic polyisoprenylated benzophenones and degradation profile of nemorosone by multiple-stage tandem mass spectrometry

Piccinelli

Campone

Piaz

et al. 2009

J. Am. Soc. Mass Spectrom.

View full text Add to dashboard Cite

Nemorosone is a polycyclic polyisoprenylated benzophenone (PPBs) with strong cytotoxic activity. It is the major constituent of Clusia rosea floral resin and brown Cuban propolis. Other PPBs found in Cuban propolis are oxidized and cyclized derivatives of nemorosone. The instability of PPBs carrying an enolizable 1,3-diketone system has been suggested, and the elucidation of this aspect is very fundamental for the evaluation of their biologic activity. Electrospray ionization multistage tandem mass spectrometry (ESI-MS n ) was employed to shed light on the origin of these derivatives of nemorosone and to define the stability of this natural product. For this purpose, we initially performed MS n experiments on seven related PPBs to obtain useful information for structural characterization of this class of compounds and to identify the degradation products of nemorosone. The proposed fragmentation pathways, supported by exact mass measurements, allowed the nature of side chains on the bicyclo core and the type and position of their modifications to be established. In a second part, the degradation profile of nemorosone under different conditions was investigated to assess the possible effects of isolation procedures, climatic, and storage conditions on its stability. Our results reveal that nemorosone undergoes rapid degradation in n-hexane and chloroform solutions. The degradation products, identified by HPLC-ESI/MS n and NMR, are identical to derivatives of nemorosone previously isolated from propolis and plants. Thus, these PPBs are artefacts formed predominantly during the extraction and purification procedures. (J Am Soc

show abstract

“…For instance, the antibacterial and antidepressant activities of Hypericum perforatum (St. John's wort) have been noted in traditional European medicine. In fact, Hypericum extracts have been tested in various clinical trials and are currently used in certain countries for the treatment of depressive, anxiety, and sleep disorders [2][3][4][5][6][7][8][9][10][11]. On the other hand, members of the Garcinia genus of tropical trees have considerable value as sources of medicines, pigments, foodstuffs, and lumber [12,13].…”

Section: Introductionmentioning

confidence: 99%

“…There are two main classes of MPAPs: the diprenylated α-acids (7) and triprenylated β-acids (8) (Figure 12.3). α-Acids are responsible for the flavor and bitter taste of beer [25] while β-acids show, among other properties, free radical scavenger activity [7,26]. Labeling and enzymological experiments have provided evidence that bitter acids are biosynthesized via condensation of three malonyl-CoA and one acyl-CoA, such as isobutyryl-CoA (9) (Scheme 12.1) [27][28][29][30].…”

Section: Introduction and Chemical Classificationmentioning

confidence: 99%

Polyprenylated Phloroglucinols and Xanthones

Theodorakis

2011

Biomimetic Organic Synthesis

View full text Add to dashboard Cite

Are acylphloroglucinols lead structures for the treatment of degenerative diseases?

Cited by 115 publications

References 52 publications

Genetic relationships of Iranian Hypericum perforatum L. wild populations as evaluated by ISSR markers

Genetic relationships of Iranian Hypericum perforatum L. wild populations as evaluated by ISSR markers

Fragmentation pathways of polycyclic polyisoprenylated benzophenones and degradation profile of nemorosone by multiple-stage tandem mass spectrometry

Polyprenylated Phloroglucinols and Xanthones

Contact Info

Product

Resources

About