Are acinic cell carcinoma and microglandular carcinoma of the breast related lesions?

Kahn, R. L.; Holtveg, Helle; Nissen, Francis; Holck, Susanne

doi:10.1046/j.1365-2559.2003.01532_1.x

Cited by 25 publications

(28 citation statements)

References 6 publications

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“…Interestingly, in 11 cases where collagen IV and laminin immunohistochemistry was performed, these MGA or MGA-like areas were entirely negative for these basement membrane markers in 8 cases [7,13,19,24]. In the remaining 3 cases [12] (including the 2 cases reported in this article), very focal positivity was noted. The cytologic appearance of tumor cells, with coarse eosinophilic granules and globules, was labeled “Paneth cell like” in 11 cases [4,7,16,19,22,24].…”

Section: Resultsmentioning

confidence: 74%

“…Furthermore, both express S-100 and are negative for myoepithelial markers and hormone receptors. The question of whether the 2 lesions are related has been previously highlighted [12], and some authors have interpreted the presence of infiltrative microglandular structures at the periphery of a breast AcCC tumor as evidence that the carcinoma arose on the background of an MGA substrate. Because IHC for laminin and collagen IV is thought to be positive in most MGA [5], in contrast to the results of such IHC in most tested cases of breast AcCC, it might appear that these markers could be used to differentiate these lesions.…”

Section: Discussionmentioning

confidence: 99%

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Acinic cell carcinoma of breast: morphologic and immunohistochemical review of a rare breast cancer subtype

et al. 2016

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Summary Acinic cell carcinoma of breast is a rare subtype of triple-negative breast carcinoma and demonstrates extensive morphologic overlap with acinic cell carcinoma of the salivary gland. In this study, we perform a detailed morphologic and immunohistochemical description of 2 cases of this rare entity and undertake a comprehensive review of all reported cases of breast acinic cell carcinoma in the English language literature to date. One-third of reported cases of breast acinic cell carcinoma have been associated with the presence of a ductal carcinoma not otherwise specified component, which is frequently poorly differentiated. Breast acinic cell carcinoma can demonstrate focal morphologic features similar to microglandular adenosis; these areas are frequently negative for collagen IV and laminin on immunohistochemistry. The true relationship between these 2 entities remains unclear, but we advocate that microglandular adenosis–like areas at the periphery of a breast acinic cell carcinoma should be considered part of the carcinomatous process and re-excised if this process extends to the initial surgical margins.

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Section: Resultsmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Acinic cell carcinoma of breast: morphologic and immunohistochemical review of a rare breast cancer subtype

et al. 2016

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“…Despite conceptual differences, microglandular adenoses/atypical microglandular adenoses and acinic cell carcinomas display histologic and immunohistochemical similarities (1, 11, 13, 15). Morphologically, both entities typically are characterized by an infiltrative proliferation of small glands lined by low-grade cuboidal to flattened cells lacking a myoepithelial cell layer (1, 11).…”

Section: Introductionmentioning

confidence: 99%

“…Immunophenotypically, microglandular adenoses/atypical microglandular adenoses and acinic cell carcinomas are characterized by strong expression of S100 protein (4–7, 9, 16) and most are of triple-negative immunophenotype (4, 6, 7, 9, 12, 13, 16). Differential diagnosis of microglandular adenoses/atypical microglandular adenoses and acinic cell carcinomas can be challenging (15, 16) and often relies on the identification of diffuse serous differentiation in acinic cell carcinomas (11, 16). The latter can be defined by the presence of intracytoplasmic zymogen-type granules or expression of acinar differentiation markers, such as lysozyme and amylase.…”

Section: Introductionmentioning

confidence: 99%

Genetic analysis of microglandular adenosis and acinic cell carcinomas of the breast provides evidence for the existence of a low-grade triple-negative breast neoplasia family

et al. 2017

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Acinic cell carcinoma is an indolent form of invasive breast cancer, whereas microglandular adenosis has been shown to be a neoplastic proliferation. Both entities display a triple-negative phenotype, and may give rise to and display somatic genomic alterations typical of high-grade triple-negative breast cancers. Here we report on a comparison of previously published data on eight carcinoma-associated microglandular adenosis and eight acinic cell carcinomas subjected to targeted massively parallel sequencing targeting all exons of 236 genes recurrently mutated in breast cancer and/or DNA repair-related. Somatic mutations, insertions/deletions and copy number alterations were detected using state-of-the-art bioinformatic algorithms. All cases were of triple-negative phenotype. A median of 4.5 (1–13) and 4.0 (1–7) non-synonymous somatic mutations per carcinoma-associated microglandular adenosis and acinic cell carcinoma were identified, respectively. TP53 was the sole highly recurrently mutated gene (75% in microglandular adenosis versus 88% in acinic cell carcinomas), and TP53 mutations were consistently coupled with loss of heterozygosity of the wild-type allele. Additional somatic mutations shared by both groups included those in BRCA1, PIK3CA and INPP4B. Recurrent (n=2) somatic mutations restricted to microglandular adenosis or acinic cell carcinomas included those affecting PTEN and MED12, or ERBB4, respectively. No significant differences in the repertoire of somatic mutations were detected between microglandular adenosis and acinic cell carcinomas, and between this group of lesions and 77 triple-negative carcinomas from The Cancer Genome Atlas. Microglandular adenosis and acinic cell carcinomas, however, were genetically distinct from estrogen receptor-positive and/or HER2-positive breast cancers from The Cancer Genome Atlas. Our findings support the contention that microglandular adenosis and acinic cell carcinoma are part of the same spectrum of lesions harboring frequent TP53 somatic mutations, and likely represent low-grade forms of triple-negative disease with no/minimal metastatic potential, of which a subset has the potential to progress to high-grade triple-negative breast cancer.

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“…Acinic cell carcinoma of the breast carcinoma is a rare tumor similar to the acinic cell carcinoma of the parotid gland [20]. Two studies [21,22] reported 2 case of acinic cell carcinoma arising in MGA, and suggested a close relationship between the two lesions. Nevertheless, some of the morphological, immunohistochemical and ultrastructural features of these lesions are different, so a histogenetic link remains to be proven.…”

Section: Discussionmentioning

confidence: 99%

Carcinoma arising in microglandular adenosis of the breast: triple negative phenotype with variable morphology

Zhong

et al. 2014

Pathology

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Are acinic cell carcinoma and microglandular carcinoma of the breast related lesions?

Cited by 25 publications

References 6 publications

Acinic cell carcinoma of breast: morphologic and immunohistochemical review of a rare breast cancer subtype

Acinic cell carcinoma of breast: morphologic and immunohistochemical review of a rare breast cancer subtype

Genetic analysis of microglandular adenosis and acinic cell carcinomas of the breast provides evidence for the existence of a low-grade triple-negative breast neoplasia family

Carcinoma arising in microglandular adenosis of the breast: triple negative phenotype with variable morphology

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