Are Abnormalities in Sarcoplasmic Reticulum Calcium Cycling Properties Involved in Trapezius Myalgia?

Green, Howard J.; Galvin, Patti; Ranney, D.; Tick, Heather; Ouyang, J.

doi:10.1097/phm.0b013e31821f6f1f

Cited by 13 publications

(8 citation statements)

References 40 publications

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“…Green et al . have reported decreased Ca‐ATPase activity and expression of both SERCA1a and SERCA2a in patients suffering from trapezius mialgia. In addition, dysfunctions of the calcium pump related to defects in activity or expression have been reported in heart failure, cancer development, and Brody's and Darier's diseases .…”

Section: Discussionmentioning

confidence: 99%

Expression of sarcoplasmic‐endoplasmic reticulum Ca‐ATPase isoforms in masticatory muscles

Sánchez

Trinks

Richard

et al. 2013

European J Oral Sciences

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The aim of this study was to characterize the sarcoplasmic-endoplasmic reticulum Ca-ATPase (SERCA) isoforms in rabbit masticatory muscles compared with those in fast-twitch muscle. It was hypothesized that combined expression of the SERCA isoforms in fast- and slow-twitch muscles accounts for lower Ca-ATPase activity. SERCA was isolated by differential centrifugation, the isoforms were determined by ELISA, and the activity of each isoform was measured using a colorimetric method. Activity was tested for significance by anova, and the distribution of isoforms was assessed using the chi-square test (P < 0.05) and correlated to SERCA activity using Spearman's rank correlation. SERCA1 was predominant (90.5%) in fast-twitch muscle, whereas a mixture of SERCA isoforms was found in masticatory muscles: 62-78% was SERCA2, 20-37% was SERCA1, and the SERCA3 content was negligible. Depressor muscles showed a significantly higher content (77.8%) of SERCA2, and elevator muscles showed a higher content (35.4%) of SERCA1. Elevator muscles showed higher expression of SERCA2a (58%), and depressor muscles showed higher expression of SERCA2b (20%). The SERCA1 content was mainly SERCA1a and significantly higher for elevator muscles (33%), whereas depressor muscles showed a higher content of SERCA1b (4%). The SERCA1 content of fast-twitch muscle was mainly SERCA1a (88.5%). It is concluded that the mixture of different SERCA isoforms, along with a substantial content of SERCA2b, in masticatory muscles would support lower Ca-ATPase activity and calcium transport.

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Section: Discussionmentioning

confidence: 99%

Expression of sarcoplasmic‐endoplasmic reticulum Ca‐ATPase isoforms in masticatory muscles

Sánchez

Trinks

Richard

et al. 2013

European J Oral Sciences

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“…Although speculatively, this may be related to altered Ca 2+ kinetics of myalgic muscles. Interestingly, Green and coworkers found a compromised sarcoplasmic reticulum Ca 2+ -ATPase activity, Ca 2+ -uptake, and Ca 2+ -release in a case-series study involving women with myalgia [46]. A slower relaxation of myalgic muscles may have negative implications for high pace work tasks where the time for recovery between contractions is minimal.…”

Section: Discussionmentioning

confidence: 99%

High-Intensity Strength Training Improves Function of Chronically Painful Muscles: Case-Control and RCT Studies

Andersen

Skotte

et al. 2014

BioMed Research International

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Aim. This study investigates consequences of chronic neck pain on muscle function and the rehabilitating effects of contrasting interventions. Methods. Women with trapezius myalgia (MYA, n = 42) and healthy controls (CON, n = 20) participated in a case-control study. Subsequently MYA were randomized to 10 weeks of specific strength training (SST, n = 18), general fitness training (GFT, n = 16), or a reference group without physical training (REF, n = 8). Participants performed tests of 100 consecutive cycles of 2 s isometric maximal voluntary contractions (MVC) of shoulder elevation followed by 2 s relaxation at baseline and 10-week follow-up. Results. In the case-control study, peak force, rate of force development, and rate of force relaxation as well as EMG amplitude were lower in MYA than CON throughout all 100 MVC. Muscle fiber capillarization was not significantly different between MYA and CON. In the intervention study, SST improved all force parameters significantly more than the two other groups, to levels comparable to that of CON. This was seen along with muscle fiber hypertrophy and increased capillarization. Conclusion. Women with trapezius myalgia have lower strength capacity during repetitive MVC of the trapezius muscle than healthy controls. High-intensity strength training effectively improves strength capacity during repetitive MVC of the painful trapezius muscle.

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“…This modification on the vascular system has been interpreted as orthosympathetic response to pain and it is related with O2 reduced presence and reduction of ATP activity [25].…”

Section: Discussionmentioning

confidence: 99%

“…Important anomalies were also observed within the muscle fibers. Three case reports published by Green et al [25] appeared as very interesting to understand intracellular biochemical changes of the myo-fascial syndrome associated with IOMNP. These authors found a decrease of O2, decrease in phospho-kinase activity, decrease [up to 45%] of Ca reuptake within the sarco-plasmatic reticulum, and disruption of ATPhasic Na-K.…”

Section: Histology and Metabolismmentioning

confidence: 99%

Structural and Functional Changes of Cervical Neuromuscular System Associated with Insidious Onset Mechanical Neck Pain: A literature Review

Mario¹,

Vanti²,

Pillastrini³

et al. 2015

Int J Phys Ther Rehab

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Background: The purpose of this review is to provide an updated overview of structural and functional changes of cervical neuromuscular system associated with Insidious Onset Mechanical Neck Pain [IOMPT]. Methods: MEDLINE and SCOPUS databases were searched. Observational studies published after 01-01-2003 in English or Italian languages were included. The following search string was used: "neck pain" AND (muscle OR "motor control" OR behaviour OR function OR endurance OR "isometric contraction") NOT (radiculopathy OR surgery OR "specific neck pain"). Results: 15 papers concerning changes in structure of neck neuromuscular system, 19 on changes in pattern of neuromuscular activation, and 16 on deficit in neuromuscular function associated to IOMNP were selected. From this review emerges that pain, whether it be artificially produced or due to IOMNP, provokes an alteration of the cervical region function and a number of anomalies in the behavior of the neuro-muscular system. IOMNP is associated with structural alterations affecting the cervical region at different levels (metabolic, histological, and even macroscopic). Changes in cervical neuromuscular system structure concern altered histology and metabolism, cross sectional area thickness, muscle fatty infiltration, trigger points generation, and alterations of muscular activation pattern. Changes in neuromuscular function concern reduced maximal voluntary contraction, alteration on proprioception, coordination and on complex functions. Conclusion:The relationships between IONMP and changes in the intrinsic properties, behavior, and function of neck muscles have now acquired evidence. There is a widespread consensus about the fact that these alterations contribute to the onset, maintenance, and recurrence of neck pain. Structural and Functional Changes of Cervical Neuromuscular System Review ArticleOpen Access IntroductionInsidious Onset Mechanical Neck Pain (IOMNP) is a common cause of discomfort and disability and a growing problem in society, resulting in significant impact on health care costs [1]. Within 6 months, 54% of adults experience IOMNP, and 5% of them complain of associated disability. Furthermore, only 6.3% of people who suffered from neck pain are free from recurrence [2]. About 0.6% of the general population is exposed to disability caused by IOMNP and females are more prone to recurrent and / or chronic pain than males [3]. The IOMNP can be considered a work-related disorder in some professions, including pilots [4][5][6][7], musicians [8][9], and workers using personal computer for prolonged times [10][11][12][13][14].Cervical spine supports the head and orients it in space, transmits forces on the upper limb and has close relations with the visual and vestibular function [15][16][17][18]. Given the complexity of this region and the close link between central nervous system (CNS) and muscles, several abnormalities in structure and function of the neuromuscular system may develop when pain occurs [2,15].The aim of this review is to pro...

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Are Abnormalities in Sarcoplasmic Reticulum Calcium Cycling Properties Involved in Trapezius Myalgia?

Cited by 13 publications

References 40 publications

Expression of sarcoplasmic‐endoplasmic reticulum Ca‐ATPase isoforms in masticatory muscles

Expression of sarcoplasmic‐endoplasmic reticulum Ca‐ATPase isoforms in masticatory muscles

High-Intensity Strength Training Improves Function of Chronically Painful Muscles: Case-Control and RCT Studies

Structural and Functional Changes of Cervical Neuromuscular System Associated with Insidious Onset Mechanical Neck Pain: A literature Review

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