Are abnormal premorbid personality traits associated with Alzheimer's disease? ‐ A case‐control study

Abstract

There is an association between abnormal personality traits and AD. Individuals with AD also appear to have had lower levels of social interactivity.

Is dependent personality disorder associated with mild cognitive impairment and dementia in Central Africa? A result from the EPIDEMCA programme

“…Furthermore, a crosssectional study showed that patients with AD were more likely than their cognitively normal spouses to present DPD (Clément et al, 2003). This was confirmed by a recent case-control study (Nicholas et al, 2010).…”

Are premorbid abnormal personality traits associated with behavioural and psychological symptoms in dementia?

“…A final point is that a very few of the informants were full-time carers at the time of interview. It is intriguing and significant that the same traits that make individuals more vulnerable to the onset of dementia (Nicholas et al, 2010) also predict these problematic behaviours (which are predominantly features of depression). Both these factors will tend to concentrate such patients in care homes, which specialise in caring for those with dementia and particularly for those with BPSD.…”

“…For older people living with dementia, both normative and psychiatric approaches can be adapted so that the premorbid personality is assessed retrospectively with an informant (Pilgrim et al, 1993;Archer et al, 2006). Premorbid personality has been found to be a significant risk factor for the age of onset for dementia (Nicholas et al, 2010) and the risk of BPSD in dementia (Low et al, 2002;Archer et al, 2007).…”

Personality traits in women with Alzheimer's disease: Comparisons with control groups with the NEO-FFI

“…It should be mentioned that other authors also refer to the particular behavior of the Conscientiousness dimension, indicating that it is highly variable among participants with AD, having observed an increase in inter-individual variability on this trait, in advanced age, perhaps due to heterogeneous pre-morbid characteristics. Even more pronounced personality alterations are reported in this dimension in individuals with higher pre-morbid levels associated with Obsessive-Compulsive Disorder (Allemand, Zimprich, & Hendriks, 2008;Chatterjee et al, 1992;Dawson et al, 2000;Nicholas et al, 2010;Pocnet et al, 2011). However, it is also possible that higher Conscientiousness scores in the pre-morbidity may be caused by a "halo effect" of the informants with respect to that characteristic in the AD participants.…”