ARDS and sepsis — definitions and new therapy

McLean, John S.; Byrick, Robert J.

doi:10.1007/bf03009692

Cited by 6 publications

(3 citation statements)

References 19 publications

(8 reference statements)

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“…This syndrome is characterized by severe hypoxemia, diffused infiltration of the lung, reduction in respiratory compliance, increase in pulmonary arterial pressure, and pulmonary resistance (McLean and Byrick, 1993;Kollef and Schuster, 1995).…”

Section: Introductionmentioning

confidence: 99%

San-Huang-Xie-Xin-Tang attenuates inflammatory responses in lipopolysaccharide-exposed rat lungs

Lin

et al. 2005

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 99%

San-Huang-Xie-Xin-Tang attenuates inflammatory responses in lipopolysaccharide-exposed rat lungs

Lin

et al. 2005

Journal of Ethnopharmacology

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“…The CSF analysis results for COVID-19-associated encephalitis showed mainly an increased lymphocytic pleocytosis and elevated CSF protein as well as positive RT-PCR or intrathecal antibody production (immunoglobulin M (IgM), IgG) [33,34,65]. Moreover, the CSF change of other viral encephalitis (such as influenza viruses and herpes zoster virus) also presented with similar features with that of COVID-19-associated CNS infection.…”

Section: Early Identification Of Sepsis: Neutrophils Lymphocytes Anmentioning

confidence: 87%

“…According to the clinical criteria of Sepsis-3, i.e., quick Sequential (sepsis-related) Organ Function Assessment (qSOFA: range, 0 -3 points, with 1 point each for tachypnea (≥ 22/min), altered mentation, or systolic hypotension (≤ 100 mm Hg), if ≥ 2 points indicates sepsis) [3], most severe COVID-19-associated ARDS and altered mentation have fully met the diagnose of sepsis [4,7,13,[62][63][64]. Moreover, the ARDS play pivotal roles in the development of multiple organ dysfunction syndrome (MODS) in septic event [65,66]. The previous studies showed that sepsis with MODS were more likely to exhibit an ABD [52,[67][68][69].…”

Section: Sepsis Is Related To Severe Covid-19-associated Abdmentioning

confidence: 99%

COVID-19-Associated Acute Brain Dysfunction Related to Sepsis

2021

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In global term, as of November 30, 2020, over 30 million people has been infected by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and more than 10,000,000 of them died of acute organ failure. Our reviews have shown that coronavirus disease 2019 (COVID-19) patients with pneumonia and acute respiratory distress syndrome (ARDS) have life-threatening acute brain dysfunction (ABD), ranging from altered mental status/delirium to stupor/coma. Altered mental status/delirium was the most common manifestation of ABD caused by severe COVID-19. The prevalence of altered mental status and/or delirium was up to 66-79.5%, and prevalence of coma was 10%. The most common clinical type of COVID-19-associated ABD was COVID-19-associated acute stroke including ischemic and hemorrhagic stroke (n > 350 cases), followed by COVID-19-associated encephalopathy (n > 200 cases), and COVID-19-associated central nervous system (CNS) infection (n > 70 cases). According to the Sepsis-3 criteria, we confess that severe COVID-19-associated ABD with ARDS and altered mental status is related to sepsis. Moreover, we also review the diagnosis and treatment of COVID-19-associated ABD with sepsis. In view of the fact that COVID-19 is at the peak of epidemic worldwide, we hope that this review will provide evidence of COVID-19 sepsis threating to the brain dysunction. Thus, recognizing the COVID-19-associated ABD related to sepsis is very important for early empirical combination therapy to survive severe COVID-19.

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The pathogenesis of inflammatory disease: Surgical shock and multiple system organ failure

Parke

1995

Inflammopharmacology

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ARDS and sepsis — definitions and new therapy

Cited by 6 publications

References 19 publications

San-Huang-Xie-Xin-Tang attenuates inflammatory responses in lipopolysaccharide-exposed rat lungs

San-Huang-Xie-Xin-Tang attenuates inflammatory responses in lipopolysaccharide-exposed rat lungs

COVID-19-Associated Acute Brain Dysfunction Related to Sepsis

The pathogenesis of inflammatory disease: Surgical shock and multiple system organ failure

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