Arcuate Fasciculus Subsegment Impairments Distinctly Associated with Memory and Language Deficits in Acute Mild Traumatic Brain Injury Patients

Wang, Tianyao; Hu, Yujie; Wang, Danni; Li, Jun; Sun, Jiahua; Wei, Chunhong; Dai, Hui; Li, Yao

doi:10.1089/neu.2021.0267

Cited by 5 publications

(2 citation statements)

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“…Furthermore, these tracts are the primary focus considering their role in memory. 6,[31][32][33][34] Based on previous studies, 4,10,23,25 we hypothesized that 1) the left-HS group will demonstrate more widespread white matter abnormalities than the right-HS group, and 2) white matter abnormalities will be less pronounced for the nonlesional MTLE group compared with the HS groups. Finally, we explored how the white matter microstructure of the CB, AF, and ILF is associated with verbal and nonverbal memory performance in individuals with MTLE.…”

Section: Key Pointsmentioning

confidence: 99%

“…Employing a method distinct from those used in most previous studies could enhance the validation of white matter microstructure changes in MTLE. Furthermore, these tracts are the primary focus considering their role in memory 6,31–34 . Based on previous studies, 4,10,23,25 we hypothesized that 1) the left‐HS group will demonstrate more widespread white matter abnormalities than the right‐HS group, and 2) white matter abnormalities will be less pronounced for the nonlesional MTLE group compared with the HS groups.…”

Section: Introductionmentioning

confidence: 99%

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Exploring the impact of hippocampal sclerosis on white matter tracts and memory in individuals with mesial temporal lobe epilepsy

et al. 2023

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ObjectiveTo investigate how the presence/side of hippocampal sclerosis (HS) are related to the white matter structure of cingulum bundle (CB), arcuate fasciculus (AF), and inferior longitudinal fasciculus (ILF) in mesial temporal lobe epilepsy (MTLE).MethodsWe acquired diffusion‐weighted magnetic resonance imaging (MRI) from 86 healthy and 71 individuals with MTLE (22 righ‐HS; right‐HS, 34 left‐HS; left‐HS, and 15 nonlesional MTLE). We utilized two‐tensor tractography and fiber clustering to compare fractional anisotropy (FA) of each side/tract between groups. Additionally, we examined the association between FA and nonverbal (WMS‐R) and verbal (WMS‐R, RAVLT codification) memory performance for MTLE individuals.ResultsWhite matter abnormalities depended on the side and presence of HS. The left‐HS demonstrated widespread abnormalities for all tracts, the right‐HS showed lower FA for ipsilateral tracts and the nonlesional MTLE group did not differ from healthy individuals. Results indicate no differences in verbal/nonverbal memory performance between the groups, but trend‐level associations between higher FA of visual memory and the left CB (r = 0.286, P = 0.018), verbal memory (RAVLT) and ‐left CB (r = 0.335, P = 0.005), ‐right CB (r = 0.286, P = 0.016), and ‐left AF (r = 0.287, P = 0.017).SignificanceOur results highlight that the presence and side of HS are crucial to understand the pathophysiology of MTLE. Specifically, left‐sided HS seems to be related to widespread bilateral white matter abnormalities. Future longitudinal studies should focus on developing diagnostic and treatment strategies dependent on HS's presence/side.

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