Architectured Helically Coiled 3D Structures from Elastomeric Poly(butylene succinate)(PBS) Copolyester

Abstract

<jats:p>&lt;div&gt;&lt;div&gt;&lt;div&gt;&lt;p&gt;Electrospinning is one of the most investigated methods used to produce polymeric fiber structures that mimic the morphology of native extracellular matrix. These structures have been extensively studied in the context of scaffolds for tissue regeneration. However, the compactness of materials obtained by traditional electrospinning, collected as two-dimensional non-woven scaffolds, can limit cell infiltration and tissue ingrowth. In addition, for applications in smooth muscle tissue engineering, highly elastic scaffolds capable of withstanding cyclic mechanical strains without suffering significant permanent deformations are preferred. In order to address these challenges, we report the fabrication of microscale 3D helically coiled structures (referred as 3D-HCS) by wet-electrospinning method, a modification of the traditional electrospinning process in which a coagulation bath (non-solvent system for the electrospun material) is used as the collector. The present study, for the first time, successfully demonstrates the feasibility of using this method to produce various architectures of 3D helically coiled structures (HCS) from segmented copolyester of poly(butylene succinate-co-dilinoleic succinate) (PBS-DLS), a thermoplastic elastomer. A mechanism for the HCS formation is proposed and verified with experimental data. Fabricated 3D-HCS showed high specific surface area, high porosity, and good elasticity. Further, the marked increase in cell proliferation on 3D-HCS confirmed the suitability of these materials as scaffolds for soft tissue engineering.&lt;/p&gt;&lt;/div&gt;&lt;/div&gt;&lt;/div&gt;</jats:p>

Enzymatic Synthesis of Polyesters and Their Bioapplications: Recent Advances and Perspectives

“…There are several polyesters that fulfill some of the mentioned requirements for the construction of scaffold for tissue engineering applications: PEG, polycaprolactone (PCL), [ 237–239 ] PBS and PBSe based systems, [ 240–242 ] polyglycerol based polymers (synthesized from combination of glycerol and diacids), [ 243–245 ] among others, which have been proven to be ideal materials for their application in skin, nerve and cardiac tissue regeneration, besides others. However, in general all these polymers have been prepared via synthetic routes requiring of high reaction temperatures and the use of organic metals as catalyst, which may drag problems in their final applications.…”

Hierarchical tubular structures from biodegradable and bioactive PEG-modified PBS-DLS copolymers

“…In our previous studies, focusing on the idea of expanding the range of PBS copolymers, we found that the incorporation of poly (ethylene glycol) (PEG) into PBS-DLS copolymers increased their hydrophilicity, rubber-like elasticity and revealed excellent processability by fused filament fabrication (FFF) known also as 3D printing. Moreover, these new materials are also easily processed into nanofibers using electrospinning [13][14][15].…”