Architecture and Flow Patterns in Capillary Networks of Skeletal Muscle in Frog and Rat1

Groom, A. C.; Ellis, Christopher G.; Wrigley, S.; Potter, Richard F.

doi:10.1159/000412781

Cited by 5 publications

(3 citation statements)

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“…Intravital microscopy has revealed that there are considerable heterogeneities in red cell distribution and velocities even within the same muscle (frog sartorius) (27). But a reduction in the degree of heterogeneity has been observed during poststimulation hyperaemia (65).…”

Section: Reduction Of Capillary Inhomogeneity By Exercisementioning

confidence: 99%

Vascular Control of Nutrient Delivery by Flow Redistribution Within Muscle: Implications for Exercise and Post-Exercise Muscle Metabolism

Clark¹,

Rattigan²,

Dora³

et al. 1998

Int J Sports Med

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There is evidence for non-nutritive flow routes within, or associated with, skeletal muscle. Large capillary-like structures are possible candidates. The proportion of flow distributed between nutritive and non-nutritive routes appears to be tightly regulated and can control muscle metabolism and contraction by regulating delivery and product removal. The portion of flow that is carried by the non-nutritive routes at rest affords a flow reserve for amplifying nutrient delivery as muscle begins to work and may determine post-exercise metabolism. Inappropriate signals, however, may diminish nutritive flow to the detriment of muscle performance and post-exercise recovery. New technologies should allow the identification of the non-nutritive routes.

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Section: Reduction Of Capillary Inhomogeneity By Exercisementioning

confidence: 99%

Vascular Control of Nutrient Delivery by Flow Redistribution Within Muscle: Implications for Exercise and Post-Exercise Muscle Metabolism

Clark¹,

Rattigan²,

Dora³

et al. 1998

Int J Sports Med

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“…Short bars = 10 pm. From Groom et al [2], groups o f capillaries. However, even if arteriolar flow were homogeneous, there would still be heterogeneity of capillary flow, because of the structure of the capillary network.…”

Section: Fig 1 Composite Photomicrographmentioning

confidence: 99%

Capillary Network Morphology and Capillary Flow

et al. 1995

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This paper examines the authors’ research on capillary network morphology and the heterogeneity of capillary red cell (RBC) perfusion in skeletal muscle with the aim of demonstrating that capillary network structure plays a major role in determining flow distribution. Capillary network morphology was examined by quantifying the heterogeneity of capillary diameters, path and segment lengths, as well as the changes in configuration that occur as vessels accommodate themselves to continual changes of fiber length. Because of the network complexity and the two-phase nature of the perfusing blood, both spatial (i.e. among capillaries) and temporal heterogeneity of capillary perfusion were predicted to result. By means of computer analysis of video images of the microcirculation in vivo, we have demonstrated that more than 70% of the total spatial heterogeneity of capillary RBC perfusion arises from the capillary network as opposed to the arterioles, and that RBC flow continuously redistributes among capillaries. The spatial heterogeneity increases substantially as the arteriolar input to the network falls, and the data predict that during low-flow states, the network will fail to distribute blood properly among its constituent vessels. Thus passive rheological mechanisms and capillary network morphology are important determinants of functional capillary density.

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“…Considerable heterogeneities in red cell distribution and velocities have been reported by Groom, Ellis, Wrigley & Potter (1986) even within the same resting muscle (frog sartorius) using in vivo microscopy, but a reduction in the degree of heterogeneity has been observed during post-stimulation hyperaemia (Tyml, 1987).…”

Section: Introductionmentioning

confidence: 99%

Local oxygen supply and blood flow regulation in contracting muscle in dogs and rabbits.

Harrison

Birkenhake

Knauf

et al. 1990

The Journal of Physiology

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2. In a further model, the analysis of hydrogen clearance curves measured in the femoral vein using intravascular needle electrodes in rabbits enabled the distribution of blood flow to be evaluated both under resting conditions and during direct 2 Hz stimulation of the vastus medialis muscle.3. Increased oxygen consumption, induced by stimulation, caused increases in capillary flow which were not necessarily accompanied by augmentation of femoral artery flow.4. Po2 histograms provided no evidence of cellular anoxia even at the maximum level of oxygen consumption.5. A two-compartment distribution of flow was measured under resting conditions, whereas only one compartment could be resolved during 2 Hz stimulation of the vastus medialis muscle in the rabbit experiments. A clear redistribution of flow was observed in the absence of any increase in total flow. 6. A model for oxygen-dependent regulation of capillary blood flow involving high-flow and normal-flow compartments is proposed.

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Architecture and Flow Patterns in Capillary Networks of Skeletal Muscle in Frog and Rat1

Cited by 5 publications

References 0 publications

Vascular Control of Nutrient Delivery by Flow Redistribution Within Muscle: Implications for Exercise and Post-Exercise Muscle Metabolism

Vascular Control of Nutrient Delivery by Flow Redistribution Within Muscle: Implications for Exercise and Post-Exercise Muscle Metabolism

Capillary Network Morphology and Capillary Flow

Local oxygen supply and blood flow regulation in contracting muscle in dogs and rabbits.

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