Archaic introgression contributed to shape the adaptive modulation of angiogenesis and nitric oxide induction in human high-altitude populations from the Himalayas
Giulia Ferraretti,
Paolo Abondio,
Marta Alberti
et al.
Abstract:It is well established that several Homo sapiens populations experienced admixture with extinct human species during their evolutionary history. Sometimes, such a gene flow could have played a role in modulating their capability to cope with a variety of selective pressures, thus resulting in archaic adaptive introgression events. A paradigmatic example of this evolutionary mechanism is offered by the EPAS1 gene, whose most frequent haplotype in Himalayan highlanders was proved to reduce their susceptibility t… Show more
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