Archaeosome: As New Drug Carrier for Delivery of Paclitaxel to Breast Cancer

Alavi, Seyed Ebrahim; Mansouri, H. R.; Esfahani, Maedeh Koohi Moftakhari; Movahedi, Fatemeh; Akbarzadeh, Azim; Chiani, Mohsen

doi:10.1007/s12291-013-0305-4

Cited by 21 publications

(19 citation statements)

References 17 publications

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“…Nanoparticles are able to enhance the therapeutic efficacy of anticancer drugs [7], owing to their ability to increase the drug concentration in tumor cells through enhancing the drug circulation time. Also, nanoparticles have the capability of delivering drugs to their target sites in an in vivo environment, and thereby they can inhibit the drugs' side effects on normal cells [6,45,46].…”

Section: Cytotoxicity Studymentioning

confidence: 99%

“…Nanomedicine and nanodelivery systems are relatively new scientific fields related to materials in the nanoscale range that are used as diagnostic devices or to deliver therapeutic agents to target sites in a controlled mode. Nanotechnology provides various opportunities for the treatment of chronic human diseases, such as cancer, through the site-specific and target-oriented delivery of correct therapeutics [7][8][9]. Kates et al [10] synthesized Cispt-loaded Poly(L-aspartic acid sodium salt) (PAA) nanoparticles (140 ± 4 nm) and evaluated its efficacy on the treatment of BC in an in vivo environment.…”

Section: Introductionmentioning

confidence: 99%

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Enhanced Efficacy of PEGylated Liposomal Cisplatin: In Vitro and In Vivo Evaluation

Ghaferi

Asadollahzadeh

Akbarzadeh

et al. 2020

IJMS

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This study aims to evaluate the potency of cisplatin (Cispt)-loaded liposome (LCispt) and PEGylated liposome (PLCispt) as therapeutic nanoformulations in the treatment of bladder cancer (BC). Cispt was loaded into liposomes using reverse-phase evaporation method, and the formulations were characterized using dynamic light scattering, scanning electron microscopy, dialysis membrane, and Fourier-transform infrared spectroscopy (FTIR) methods. The results showed that the particles were formed in spherical monodispersed shapes with a nanoscale size (221–274 nm) and controlled drug release profile. The cytotoxicity effects of LCispt and PLCispt were assessed in an in vitro environment, and the results demonstrated that PLCispt caused a 2.4- and 1.9-fold increase in the cytotoxicity effects of Cispt after 24 and 48 h, respectively. The therapeutic and toxicity effects of the formulations were also assessed on BC-bearing rats. The results showed that PLCispt caused a 4.8-fold increase in the drug efficacy (tumor volume of 11 ± 0.5 and 2.3 ± 0.1 mm3 in Cispt and PLCispt receiver rats, respectively) and a 3.3-fold decrease in the toxicity effects of the drug (bodyweight gains of 3% and 10% in Cispt and PLCispt receiver rats, respectively). The results of toxicity were also confirmed by histopathological studies. Overall, this study suggests that the PEGylation of LCispt is a promising approach to achieve a nanoformulation with enhanced anticancer effects and reduced toxicity compared to Cispt for the treatment of BC.

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Section: Cytotoxicity Studymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enhanced Efficacy of PEGylated Liposomal Cisplatin: In Vitro and In Vivo Evaluation

Ghaferi

Asadollahzadeh

Akbarzadeh

et al. 2020

IJMS

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“…Drug releasing of archaeosomes Paclitaxel was examined within 26 h which showed that the most drug release occur during first 3 h. The cytotoxicity effect of archaeosomes Paclitaxel on breast cancer's cell line was evaluated by MTT assay which results showed that the cytotoxicity result of archaeosomes Paclitaxel on breast cancer's cell line is more than that of the standard Paclitaxel formulation. New drug delivery of Paclitaxel using archaeosomes, increases the therapeutic index of the drug (Alavi et al, 2014).…”

Section: New Drug Carrier For Delivery Of Paclitaxel To Breast Cancermentioning

confidence: 99%

Archaeosomes: an excellent carrier for drug and cell delivery

et al. 2015

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Archaeosomes as liposomes made with one or more ether lipids that are unique to the domain of Archaeobacteria, found in Archaea constitute a novel family of liposome. Achaean-type lipids consist of archaeol (diether) and/or caldarchaeol (tetraether) core structures. Archaeosomes can be produced using standard procedures (hydrated film submitted to sonication, extrusion and detergent dialysis) at any temperature in the physiological range or lower, therefore making it possible to encapsulate thermally stable compounds. Various physiological as well as environmental factors affect its stability. Archaeosomes are widely used as drug delivery systems for cancer vaccines, Chagas disease, proteins and peptides, gene delivery, antigen delivery and delivery of natural antioxidant compounds. In this review article, our major aim was to explore the applications of this new carrier system in pharmaceutical field.

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“…Based on the size of the ULVs, they are further divided into small unilamellar vesicles (SUVs) of 20 to 100 nm diameter, medium unilamellar vesicles (MUVs), large unilamellar vesicles (LUVs) of larger than 100 nm diameter, and giant unilamellar vesicles (GUVs) of larger than 1,000 nm diameter [9]. Liposome-based carrier systems such as immunoliposomes, virosomes, stealth liposomes, and archaeosomes contain lipid bilayers that are biocompatible and may improve the solubility and stability of core materials [10][11][12][13].…”

Section: Liposomesmentioning

confidence: 99%

An Overview of Nanotechnology in Food Science: Preparative Methods, Practical Applications, and Safety

Park

Kwon³

et al. 2018

Journal of Chemistry

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As the researches to utilize nanotechnology in food science are advanced, applications of nanotechnology in various fields of the food industry have increased. Nanotechnology can be applied to the food industry for production, processing, storage, and quality control of foods. Nanomaterials, unlike conventional microscale materials, having novel characteristics can improve sensory quality of foods by imparting novel texture, color, and appearance. Nanotechnology has been used to design nanosensors for detection of harmful components in foods and a smart packaging system enabling to recognize food contamination very rapidly and sensitively. Nanoencapsulation is the most significant technology in food science, especially for bioactive compounds and flavors. Targeted delivery systems designed with nanoencapsulation can enhance bioavailability of bioactive compounds after oral administration. In addition, nanoencapsulation enables to control the release of flavors at the desired time and to protect the degradation of flavors during processing and storage. In this review, current applications of nanotechnology in food science including flavor control, enhancement of bioavailability of bioactive compounds, and detection of deleterious substances in foods are presented. Furthermore, this article overviews classification, preparative methods, and safety issues of nanomaterials for food science. This review will be of help to provide comprehensive information for newcomers utilizing nanotechnology to the food sector.

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Archaeosome: As New Drug Carrier for Delivery of Paclitaxel to Breast Cancer

Cited by 21 publications

References 17 publications

Enhanced Efficacy of PEGylated Liposomal Cisplatin: In Vitro and In Vivo Evaluation

Enhanced Efficacy of PEGylated Liposomal Cisplatin: In Vitro and In Vivo Evaluation

Archaeosomes: an excellent carrier for drug and cell delivery

An Overview of Nanotechnology in Food Science: Preparative Methods, Practical Applications, and Safety

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