Arc-welders' Lung

Mann, Bertram; Lecutier, Edmond R.

doi:10.1136/bmj.2.5050.921

Cited by 12 publications

(7 citation statements)

References 2 publications

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“…The total iron concentration in our welder was, at most, only 10 times higher than that in control tissue. Other authors have found much higher values for total iron (Mann and Lecutier, 1957;Angervall et al, 1960;Morgan and Kerr, 1963;Meyer et al, 1967;Hewitt and Hicks, 1973). These analyses, however, have included endogenous iron, which tends to increase in the presence of retained lung contaminants (Casswell et al, 1970).…”

Section: Discussionmentioning

confidence: 89%

“…Conventional chemical analysis of lung tissue has shown a 15-100 times higher iron content in the lungs of welders than in those of unexposed subjects (Mann and Lecutier, 1957;Angervall et al, 1960; Morgan and Kerr, 1963;Meyer et al, 1967), but it has not been possible to distinguish exogenous (inhaled) iron from that of endogenous sources. Recently neutron activation analysis has been used to determine the composition of manual mild steel arc welding-fume contaminants in lung tissue (Hewitt and Hicks, 1973), and the electron microscope has been used to study the shape, size and chemical composition of stainless steel weldingfume contaminants in lung biopsies (Stettler et al, 1977).…”

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confidence: 99%

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Amount and distribution of fume contaminants in the lungs of an arc welder post mortem.

Kalliomäki¹,

Kelhä²,

Lakomaa³

et al. 1979

Occupational and Environmental Medicine

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This study describes various post-mortem examinations of the lungs of a shipyard arc welder. These investigations comprised morphological methods, including gross pathology and radiography, histological and ultrastructural examinations, chemical analysis of lung tissue, and sensitive magnetic measurements, which can now be used to detect magnetic contaminants, such as welding fume, in human tissue. Such methods can also show the distribution of contaminants. The amount of welding-fume contaminants was low, only 110 mg. The contaminant iron seemed to represent only 10% of the total iron chemically analysed in lung tissue. The concentration of the total iron was 4-10 times higher than that in control tissue. Contaminants tended to collect in the central areas of the lungs. Two concentration centres could be observed in each lung, one anterior and one posterior. There was slight fibrosis around pigmented areas. Histological findings were similar to those of previous studies. Transmission electron micrographs showed that enlarged lysosomes of macrophages contained electron-dense granules, 450 nm to less than 5 nm in diameter, which formed aggregates and short chains, and resembled welding-fume particles in the breathing zone. Our results show the value of studying the same material by a number of inter-related methods.

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Section: Discussionmentioning

confidence: 89%

mentioning

confidence: 99%

Amount and distribution of fume contaminants in the lungs of an arc welder post mortem.

Kalliomäki¹,

Kelhä²,

Lakomaa³

et al. 1979

Occupational and Environmental Medicine

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“…Welding produces miscellaneous gases and particles that has various impact on respiratory system. Long-term exposure to welding fumes may result "welders'lung" (1,2).…”

Section: Introductionmentioning

confidence: 99%

“…Welders' lung is a result of complex effects of welding fumes which together affect the airways and parenchyma together, et all levels of the respiratory tract (2,3). Siderosis develops by deposition of iron oxide in alveolar macrophages and interstitium which result in prolonged exposure to welding fumes (2,4).…”

Section: Introductionmentioning

confidence: 99%

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et al. 2018

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Fibrogenic potential of welding fumes

Stern¹,

Pigott

Abraham

1983

J of Applied Toxicology

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A search of 3600 indexed pathology cases has disclosed pulmonary fibrosis in 29 welders. Scanning electron microscopy of biopsy material revealed macrophages laden with inorganic particulates which have characteristics compatible with welding aerosols. In order to establish a possible relationship between fibrotic reaction and welding-fume exposure, the fibrogenic potential fo some 11 different welding fumes and metallic aerosols, considered to be reference standard surrogates for the commonly used welding technologies and applications responsible for 70% of welders exposure, were screened using the Rat Peritoneal Macrophage in vitro bioassay. Only one class of fumes, that from the manual metal arc welding of stainless steel, showed distinct fibrogenic potential. This fume is, however, not common to more than four or five of the heretofore 90 cases of pulmonary fibrosis reported among welders. Thus, although insoluble Cr(VI) is probably the active fibrogen in stainless steel fumes, an etiological factor common to all fibrogenic welding exposures must be sought. It is tentatively proposed to be NO2, a potential experimental in vivo fibrogen copiously produced by certain welding processes and ubiquitous at low concentrations in the welding environment.

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Arc-welders' Lung

Cited by 12 publications

References 2 publications

Amount and distribution of fume contaminants in the lungs of an arc welder post mortem.

Amount and distribution of fume contaminants in the lungs of an arc welder post mortem.

Look closer to welders’ lung

Fibrogenic potential of welding fumes

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