Arc-modulated radiation therapy based on linear models

Zhu, Xiaofeng; Thongphiew, Danthai; McMahon, Ryan; Li, Taoran; Chankong, Vira; Yin, Fang‐Fang; Wu, Q

doi:10.1088/0031-9155/55/13/020

Cited by 2 publications

(2 citation statements)

References 30 publications

(39 reference statements)

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“…Given the dynamic feature of beams in VMAT, the leaf sequencing algorithm has to deal with more mechanical constraints related to gantry speed, leaf speed, and dose rate than those of static beams. Mixed integer linear programming (MILP) was successfully applied in many industrial applications due to its capability in handling large-scale optimization problems [ 30 , 31 ]. In this study, a MILP model was developed using a commercial optimization software package (IBM ILOG CPLEX).…”

Section: Methodsmentioning

confidence: 99%

A fast optimization approach for treatment planning of volumetric modulated arc therapy

Yan

Dai

2018

Radiat Oncol

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BackgroundVolumetric modulated arc therapy (VMAT) is widely used in clinical practice. It not only significantly reduces treatment time, but also produces high-quality treatment plans. Current optimization approaches heavily rely on stochastic algorithms which are time-consuming and less repeatable. In this study, a novel approach is proposed to provide a high-efficient optimization algorithm for VMAT treatment planning.MethodsA progressive sampling strategy is employed for beam arrangement of VMAT planning. The initial beams with equal-space are added to the plan in a coarse sampling resolution. Fluence-map optimization and leaf-sequencing are performed for these beams. Then, the coefficients of fluence-maps optimization algorithm are adjusted according to the known fluence maps of these beams. In the next round the sampling resolution is doubled and more beams are added. This process continues until the total number of beams arrived. The performance of VMAT optimization algorithm was evaluated using three clinical cases and compared to those of a commercial planning system.ResultsThe dosimetric quality of VMAT plans is equal to or better than the corresponding IMRT plans for three clinical cases. The maximum dose to critical organs is reduced considerably for VMAT plans comparing to those of IMRT plans, especially in the head and neck case. The total number of segments and monitor units are reduced for VMAT plans. For three clinical cases, VMAT optimization takes < 5 min accomplished using proposed approach and is 3–4 times less than that of the commercial system.ConclusionsThe proposed VMAT optimization algorithm is able to produce high-quality VMAT plans efficiently and consistently. It presents a new way to accelerate current optimization process of VMAT planning.

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Section: Methodsmentioning

confidence: 99%

A fast optimization approach for treatment planning of volumetric modulated arc therapy

Yan

Dai

2018

Radiat Oncol

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“…In this approach, the challenge is to devise a sequencing algorithm that converts the intensity vectors at every beam angle into leaf trajectories of the MLC to optimally approximate the dose distribution achievable by the full IMRT solution [55, 63]. …”

Section: The Full Imrt Problem Versus Limited Angle Imrtmentioning

confidence: 99%

From analytic inversion to contemporary IMRT optimization: Radiation therapy planning revisited from a mathematical perspective

Censor

Unkelbach

2012

Physica Medica

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In this paper we look at the development of radiation therapy treatment planning from a mathematical point of view. Historically, planning for Intensity-Modulated Radiation Therapy (IMRT) has been considered as an inverse problem. We discuss first the two fundamental approaches that have been investigated to solve this inverse problem: Continuous analytic inversion techniques on one hand, and fully-discretized algebraic methods on the other hand. In the second part of the paper, we review another fundamental question which has been subject to debate from the beginning of IMRT until the present day: The rotation therapy approach versus fixed angle IMRT. This builds a bridge from historic work on IMRT planning to contemporary research in the context of Intensity-Modulated Arc Therapy (IMAT).

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Arc-modulated radiation therapy based on linear models

Cited by 2 publications

References 30 publications

A fast optimization approach for treatment planning of volumetric modulated arc therapy

A fast optimization approach for treatment planning of volumetric modulated arc therapy

From analytic inversion to contemporary IMRT optimization: Radiation therapy planning revisited from a mathematical perspective

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